Jun
08
2013

Breast Cancer Due To Stress

By | Cancer, Health, Hormones, Stress management, Women’s Diseases

The medical profession is of the opinion that breast cancer is multi-factorial, where genetics, body weight, hormonal and other factors play a role in causing it (details see Ref. 1). The Wisconsin Longitudinal Study (United States) showed in May 2012 that girls from families of lower socioeconomic status have a higher risk of breast cancer later in life. The study also showed that girls from families with a higher socioeconomic status had a low risk of breast cancer later in life.

The same cohort of women was the subject of another study, which was just published in April of 2013. In this study the question was asked whether stress in career women could cause a higher rate of breast cancer. Using 1957–2011 data showed that 297 of the 3682 White non-Hispanic women of the Wisconsin Longitudinal Study developed breast cancer. Details of the study showed that the peak of the age for breast cancer to develop was around 55 to 65. Women working with the lowest job authority had the lowest rate of breast cancer. High job authority, being the “boss”, was associated with a 1.57-fold (range 1.12 – 2.18-fold) increase in breast cancer. There was also a striking difference between the lengths of job stress exposure, 5 years versus 15 years with both groups, high and low job authority. The lowest risk of breast cancer was for the low stress group of women who worked under these conditions only for 5 years, followed by the same group who had worked there for 15 years. Slightly above that latter group was the breast cancer risk for the 5-year employed high job authority. The highest group of breast cancer risk, rising above all other groups, was the group with high job authority, exposed to this for type of stressful situation for 15 years (see Fig. 1 of the above link). The researchers interpreted their data to say that the majority of the breast cancer risk in these groups of women was due to the stress hormone (cortisol). Minor contributions were thought to be due to the carcinogenic effect of estrogens.

Breast Cancer Due To Stress

Breast Cancer Due To Stress

 

Review of the literature regarding this study

Dr. Lee had been publishing about estrogen dominance for many years (Ref. 2 and 3). When women age, their ovaries do not produce as much progesterone during the luteal phase as in younger years and above the age of 30 to 35 anovulatory cycles are common. During anovulatory cycles ovulation (=release of an egg) does not occur and there is no formation of a corpus luteum that would produce progesterone for 2 weeks. The end result is that there is a lack of progesterone as a woman ages. This has been discussed in detail in Ref. 3. Dr. Lee called this disbalance of estrogen and progesterone “estrogen dominance”. This is one of the important causes of breast cancer as explained in Ref.2. This can be caused by aging, xenoestrogens from exposure to artificial fertilizers, insecticides and cosmetics, but also taking the birth control pill for prolonged periods of time. However, stress by itself can also produce a state of estrogen dominance. Dr. Lee explained (page 180 of Ref. 2) that the cortisol-binding globulin (CBG), which binds both cortisol and progesterone, is a storage form for both of these hormones. As a person is under chronic stress the CBG is increased binding both cortisol and progesterone. This means that less of these hormones are preliminarily available in their free form for body consumption as CBG binding is a storage form for these hormones. The free progesterone, which is the only biologically active progesterone portion, is lowered as a result of stress causing estrogen dominance. If estrogen is not opposed by progesterone, it is cancer causing for breast tissue and the uterine lining, which translates into being at risk for breast and uterine cancer. Only supplementation with bioidentical progesterone cream as described in Ref. 3 will rebalance the hormones (progesterone/estrogen balance) and reduce the cancer risk. The symptoms of estrogen dominance according to Ref. 4 (p. 29) are fatigue, weight gain, less ability to handle stress, headaches, mood swings, loss of sex drive, irregular periods, uterine fibroids, fibrocystic breasts, fluid retention (particularly around the ankles), irritability and depression.

Practical recommendations for women in stressful jobs

Above the age of 35 it is wise to have a saliva hormone test done, checking the levels of 5 hormones (cortisol, DHEAS, estrogen, progesterone and testosterone). This establishes the baseline values for these hormones. The relationship between the levels of these hormones determines whether they are balanced or not. For instance, if the ratio between progesterone and estrogen (divide the level of progesterone by the level of estrogen) is less than 1 in 200 the patient has estrogen dominance (see Ref. 5). You may need to get a naturopathic physician or an A4M physician who is knowledgeable in interpreting these results and treating the patient with bioidentical hormones. Some women may need to start bioidentical hormone replacement at this point if a hormone deficiency is noticed.

In order to counterbalance stress you need to schedule some time for yourself regularly where you can relax, do yoga exercises, meditation, and/or self-hypnosis. Make sure you get enough sleep. Avoid alcohol, if you can as it interferes with a restful sleep, or reduce alcohol to the absolute minimum. Alcohol causes decreased hormone production of both ovaries. It also weakens the adrenal glands contributing to hormone disbalance. Usually the first hormone to show a decline with stress and aging is progesterone. It has to be measured by the saliva test. Ref. 2 and 3 explain why: progesterone is fat-soluble and is transported through the blood in its free form through red blood cells. However, a progesterone blood test measures the serum progesterone level after the red blood cells have been spun down in the centrifuge, which leads to misleading results; only the saliva test gives reliable results in terms of bio-available progesterone levels. Many conservative physicians blindly insist on blood progesterone levels, which will lead to false results. This is why you need a naturopathic physician or A4M physician to help you with the proper interpretation of the test results.

If saliva progesterone levels are low, progesterone cream (bio-identical, as explained below) is applied daily in a concentration that will normalize the levels. Physicians who have been influenced by drug company representatives may suggest to use Provera (or another progestin, which are synthetic hormone substances) as a “supplement”, but this is known from the Women’s’ Health Initiative to cause breast cancer, heart attacks and strokes.

Do the proper monitoring tests with saliva testing and only substitute what is missing with bioidentical hormone creams. Otherwise a low fat, low refined carbohydrate diet, exercise and other good health habits as I have summarized in this link will be very beneficial to prevent stress as a cause of breast cancer. Ref. 6 is also a useful text written for the layperson explaining what to do when stress leads to adrenal fatigue.

References

  1. A review of the causes of breast cancer: http://www.nethealthbook.com/articles/causesofbreastcancer.php
  2. Dr. John R. Lee, David Zava, Ph.D. and Virginia Hopkins: “What your doctor may not tell you about breast cancer”. 2002 Hachette Book Group, New York,NY, USA.
  3. Dr. John R. Lee: “Natural Progesterone”.  2nd edition. Jon Carpenter Publishing, 1999 Charlbury, England.
  4. George Gillson, M.D., Ph.D.: “You’ve hit menopause. Now what? 3 simple steps to restoring hormone balance” 2nd edition, 2004, Rocky Mountain Analytical Corp., Calgary, AB, Canada.
  5.  John R. Lee, M.D. and Virginia Hopkins: “Dr. John Lee’s Hormone Balance Made Simple- The Essential How-to Guide to Symptoms, Dosage, Timing, and More”. Wellness Central Hachette Group USA, New York, NY 10017. Published 2006. Page 57 discusses saliva testing and states: “The healthy ratio of progesterone to estradiol is at least 200 to 1 and can go up to 1,000 to 1 in women using transdermal (delivered through the skin with cream, gels, oils) progesterone.”
  6. James L. Wilson, ND, DC, PhD: “Adrenal Fatigue, the 21sty Century Stress Syndrome – what is it and how you can recover”; Second printing 2002 by Smart Publications, Petaluma, Ca, USA

Last edited Nov. 6, 2014

Feb
19
2013

Forget The Glass Of Red Wine For Good Health

By | Cancer, Health, Heart Disease, Medical Condition, Nutrition, Obesity, Prevention, Stroke, Substance abuse, Vitamins and supplements

This article is about the statement “forget the glass of red wine for good health”. For over 10 years there was the rule to limit alcohol intake. It said  “1 glass of red wine for women and 2 glasses of red wine for men” daily.  This was the recommendation in order to prevent a heart attack or a stroke. Now we are confronted with new research from Boston showing that even small amounts of alcohol are bad for you as alcohol is a carcinogen (=cancer producing substance). Misinformation like this occurs when science concentrates only on one angle of health. Researchers focussed on cardiovascular disease prevention.  The other part of the equation, the carcinogenic effect of alcohol, was disregarded.

Australian study about the risk of cancer from alcohol consumption

In 1996 this Australian study followed 1236 men and 1569 women 60 years and over for more than 5 years and studied their mortality rates as a function of alcoholic drink intake. The authors found that there was a short-term protective effect with regard to cardiovascular/stroke mortality. Mortality was the end point for both cardiovascular disease and for cancer. Researchers took the study as evidence that alcoholic beverages protect to a certain degree from strokes and heart attacks. The authors were aware that alcohol was cancer causing as they stated, “Those taking any alcohol exhibited an increased proportion of deaths due to cancer at the expense of a reduced proportion of CHD and stroke deaths”.

Popular press is often misleading

But the popular press never mentioned this part in popular articles. Also, alcohol/cardio-protective recommendations did not mention the cancer danger. The authors also were aware that the observation time of 5 years was on the short side. We know from other studies that alcohol toxicity requires a longer observation time such as 15 to 20 years or longer to show significance in a multitude of cancers.

Alcohol consumption linked to cancer risk

As already mentioned above, the new survey of alcohol-caused cancer went through the popular press. Dr. Timothy S. Naimi from Boston University Medical Center was the main investigator of an international team of scientists. The study found that alcohol consumption is responsible every year for 18,200 to 21,300 cancer deaths in the US (that is 3.2% to 3.7% of all US cancer deaths). The authors of the study determined that every person who dies from alcohol related causes lost on average approximately 18 years of his/her life (scientists call this “years of potential life lost”).  51% of women developed breast cancer from alcohol exposure, 62% of men came down with upper airway and esophageal cancers. Less than 1.5 drinks per day caused between 26% and 35% of alcohol-related cancer deaths. No safe lower margin existed. The authors concluded, “Reducing alcohol consumption is an important and underemphasized cancer prevention strategy”.

Other research supporting the statement: “forget the glass of red wine for good health”

Interestingly, in 2006 other research looked at alcohol caused cancer cases in the world based on WHO data and concluded that with the increased worldwide consumption of alcohol, particularly in East Asia, preventative steps regulating consumption of alcoholic drinks would be wise.

A recent study in 2012 where cancer rates in the US were compared between Hispanics and Caucasians showed that Hispanics had higher rates of stomach cancer, liver cancer, uterine/cervix cancer and gallbladder cancer. The authors concluded that more screening is necessary in Hispanics  such as Pap tests. Also this ethnic group requires effective vaccines (like Gardasil) against the human papilloma virus. In addition, patients need to reduce obesity, curtail alcohol consumption and reduce tobacco use.

There is no safe level of alcohol consumption, not even the “1 drink for women and 2 drinks for men” (heart attack prevention), because cancer incidence increases with increasing alcohol consumption in a linear relationship.

Effect of alcohol on the body

What does alcohol do in the body that it is so dangerous to your cells? Many cancer researchers have researched this question in detail. Essentially, alcohol is by itself a toxin for your cells (the targets being sub particles in your cells called microsomes and mitochondria). Your liver metabolizes alcohol into acetaldehyde, your kidneys excrete it and your lungs exhale it (this is how a breathalyzer can detect how much you have been drinking). All of these chemical changes in your cells release free radicals, which in turn attack other cells. This sets up a chronic inflammatory process, which breaks down your immune system, leads to cell mutations and finally to cancer.

Forget The Glass Of Red Wine For Good Health

Forget The Glass Of Red Wine For Good Health

Protection from cancer and cancer prevention

What protects you from cancer?  It is the antioxidants that stabilize the above-mentioned processes: vitamin C, glutathione, vitamin D 3, curcumin, multiple vitamins, magnesium, flavonoid foods, cruciferous foods (like broccoli), exercise and soluble fiber.

So, if you were serious about cancer prevention, you may want to stop any alcohol intake. Instead take the above mentioned supplements. The heart attack and stroke protection will be achieved by flavonoid foods (perhaps specifically adding resveratrol 250 mg per day as well) and exercise.

If you were less conscientious about cancer prevention, at least reduce your alcohol consumption. Perhaps you want to drink the occasional glass of wine or beer. But avoid high percentage spirits and remember, the less the better! You may be toasting to ill health with that glass of wine. Say no to false advertising of the wine industry! Your body will thank you for it.

More information on alcoholism: http://nethealthbook.com/drug-addiction/alcoholism/

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Sep
01
2008

Survey Shows People Underestimate Lifestyle Factors As Cancer Causes

By | Cancer, Health, Nutrition, Obesity, Prevention, Weight loss

Roy Morgan Research Company and Gallup International have released an opinion poll study at the recent International Union Against Cancer’s World Cancer Congress in Geneva (August 27 to 31, 2008) that reveals significant differences among low-income countries and high-income countries. Cancer of the liver and other cancers can be caused by alcohol and throat and lung cancer as well as others are caused by carcinogens from cigarette smoking. These are medical facts that have been well established. But the opinion poll showed that there is ignorance and confusion in the public both in poor and wealthy nations. For instance in high-income countries 42% felt that there was no cancer risk from drinking alcohol and 8% were unsure, in low-income countries 15% were of the opinion that alcohol was not a cancer risk and 29% were unable to say. Other differences were that 62% of people in wealthier nations believed that cancer was one of the three top health issues in the country, while only 36% of people in poorer nations believed this. On the other hand with so much information about pollution in the press 76% to 78% of people living in middle and high income countries are of the opinion that this is an important cause of cancer while only 30% believe this in the poorer countries. The reality is that smoking and drinking of alcohol are more important in terms of cancer causation than pollution is.

Survey Shows People Underestimate Lifestyle Factors As Cancer Causes

Survey Shows People Underestimate Lifestyle Factors As Cancer Causes

David Hill, president-elect of the International Union Against Cancer, said that these opinion polls reveal data about attitudes and believes previously unknown. This kind of data can be used to formulate programs for cancer prevention so that the public is accurately informed about cancer facts and they learn in rich and poor countries alike that factors like smoking, drinking alcohol and a high body mass index are more significant cancer causes than pollution. Pollution is more difficult to control by the individual, but these life style factors can be modified, and people need to be empowered to make the right choices. People have the power to stop smoking, to cut down their alcohol consumption and to increase their exercise, which helps them to shed pounds.

More information about causes of cancer: http://nethealthbook.com/cancer-overview/overview/epidemiology-cancer-origin-reason-cancer/

International Union Against Cancer’s World Cancer Congress in Geneva (August 27 to 31, 2008)

Last edited November 3, 2014

Jan
01
2007

Acetaminophen Overdosing Hazards

By | Arthritis, Infectious Disease, Pain, Prevention

The FDA has expressed some concerns about the self-medicating with acetaminophen as this can led to an acetaminophen overdose. The over-the-counter medication is commonly used and especially in the winter season many sufferers of colds or influenzas will keep it handy. It is readily available, not only in pharmacies but also in supermarkets under the generic name or under brand names such as the commonly used Tylenol. It exists in dosages for adults and there are pediatric preparations like Children’s Tylenol. Acetaminophen is also a common ingredient in cold remedies. Every vial displays a clear warning that the content is enough to cause serious harm. Dosage instructions are also clearly spelled out.
More than 200 million people take Tylenol each year and 400 people die of liver failure every year, as they have accidentally taken too much.
Dr. Charles Cain from the New York Presbyterian Hospital has cautioned that overdoses can happen relatively easy. A patient is not to exceed 4 grams of acetaminophen per day. If the pain reliever is taken every 4 hours instead of the recommended interval of 6 hours, such as 2 extra-strength Tylenol at 500 mg each and some cold medication is added to that, patients may easily reach 4-6 grams of acetaminophen per day. If this practice continues for a few days, it can lead to liver damage, because the liver cannot keep up with the elimination of the drug. Other substances metabolized by the liver such as alcohol can become a serious hazard, if they are combined with acetaminophen. The effects of alcohol slow down the elimination of Tylenol by the liver.

Acetaminophen Overdosing Hazards

Acetaminophen Overdosing Hazards

It is for this reason that it is important to observe closely how much of the medication is taken in total: if a patient is already taking Tylenol for headaches, more acetaminophen (Tylenol) in the form of an over-the-counter cold medication should not be added as  would be reached.
These medications have to be used with an eye to overall daily use and the amount used over a period of time. Used with care acetaminophen remains very safe.

Reference: December 20, 2006 online issue of Time

Last edited December 5, 2012

Apr
01
2005

Sweet Alcohol Has Bitter Consequences

By | Gastrointestinal Disease, Prevention, Substance abuse

Aggressive marketing of sugar/alcohol, called “girlie drinks” or “alcopops”, are luring young girls into alcohol consumption. Colorful commercials convey the image of fun and sexy drinks, and as a result, the percentage of girls who drink is more on the rise than boys. The American Medical Association has conducted two teen surveys, and discovered some troublesome facts:
-Approximately one third of teen girls have tried the aggressively marketed alcopops.
-About one in six were sexually active after drinking.
-One quarter has driven after drinking or ridden in a car with a driver who had been drinking.
-The average age of the first alcoholic drink is now 13.
It is obvious from the marketing content, that alcoholic beverage marketers go after young teens, reported Dr. Bob Mann PhD, senior scientist at the Center for Addiction and Mental Health in Toronto.

This advertising is highly effective, as it was observed in a study, which was conducted several years ago. Young males were questioned two months after a brewery launched an advertising campaign for a high-alcohol beer that was geared towards young males. 66% of underage drinkers were consuming the product.

Sweet Alcohol Has Bitter Consequences

Sweet Alcohol Has Bitter Consequences

In Canada federal and provincial governments are out of the regulation of alcohol advertising. It is essential that parents, educators and family physicians point out the hazards of excessive alcohol use long before the first drink is sampled. An American Medical Association poster shows a young girl taking a swallow from a bottle. The headline warns: “Girlie Drinks…women’s diseases”, and the list of diseases are shown: brain damage, STD’s, heart problems, liver disease, and menstrual disorders.

More information about alcoholism and the effects of alcohol on the body: http://nethealthbook.com/drug-addiction/alcoholism/

Reference: Medical Post, March 1, 2005, page 23

Last edited October 27, 2014