• Ultraprocessed Food Leads to Premature Aging

    Ultraprocessed Food Leads to Premature Aging

    An article in the medical journal “Medical News Today” found that ultraprocessed food leads to premature aging. What are ultraprocessed foods? The NOVA Food Classification System explains what ultraprocessed foods (UPFs) are and what other ones are not. Examples of ultraprocessed foods are: fatty, sweet, savory … [Read More...]

  • Vital Information about Cholesterol Drugs

    Vital Information about Cholesterol Drugs

    Most people know about statins to treat high cholesterol, but they do not have vital information about cholesterol drugs. Recently an article appeared in CNN, which was very informative. In the following I will review what is new about cholesterol lowering drugs. PCSK9 inhibitors, which are monoclonal … [Read More...]

  • Common Chemicals Affecting your Health

    Common Chemicals Affecting your Health

    There are common chemicals affecting your health that have been known since the 1950’s. They have the name PFAS, which stands for perfluoroalkyl and polyfluoroalkyl substances. There was a review article recently in CNN describing the complexity of PFAS, the toxicity, and what you can do to improve your risk. People … [Read More...]

  • Cardiovascular Risk Markers Predict Heart Attacks and Strokes

    Cardiovascular Risk Markers Predict Heart Attacks and Strokes

    An article in The New England Journal of Medicine stated that cardiovascular risk markers predict heart attacks and strokes. A summary of this study was also published by NBC News. 30-year follow-up of the Women’s Health Study This is based on a 30-year follow-up study of the Women’s Health Study. In the beginning … [Read More...]

  • Red Meat and Processed Meat Can Become a Cause of Diabetes

    Red Meat and Processed Meat Can Become a Cause of Diabetes

    A clinical study at the end of 2023 showed that red meat and processed meat can become a cause of diabetes. The authors published the results of this study in The American Journal of Clinical Nutrition on December 2023. Results of the study Notably, the study consisted of several pooled studies. To emphasize, … [Read More...]

  • Ozempic and Wegovy can Lead to Blindness in one Eye

    Ozempic and Wegovy can Lead to Blindness in one Eye

    Shocking medical news found that Ozempic and Wegovy can lead to blindness in one eye. Ozempic was approved by the FDA for treatment of diabetes. Wegovy, which is the same drug, got FDA approval for treatment of obesity. The pharmacological name of the drug is semaglutide. Both brand names of the drug are very … [Read More...]

    Sep
    24
    2014

    Two Approaches To Heart Disease

    Over the years I noticed that there are two approaches to heart disease that people and physicians seems to subscribe to.

    1.The conventional approach to heart disease

    The patient essentially ignores health advice, may smoke cigarettes and eat in a lot of fast food restaurants. People who do not care about their heart drink sodas, eat lots of sugar, starch and processed foods. They may think that they are invincible. Famous politicians have subscribed to this type of approach including former vice president, Dick Cheney.

    But the big surprise comes when acute chest pain hits and an ambulance has to be called. We are lucky in the industrial countries where a 911 service is available. You call that number when in distress and an ambulance with all the modern equipment will rush to you. The problem though is that you have neglected your arteries for all those years and it is likely that one or two of the three coronary heart vessels are severely narrowed so much that your heart reported chest pain. This pain signals that one area of the heart muscle was not getting enough oxygen and nutrients.

    On arrival at the hospital the emergency physician sees you. Nurses put monitors up, attach electrodes to you, and IV-lines are put into your veins, just in case things get worse and they would need to give you quick life-saving medicine intravenously. They have also given you an oxygen mask, and after 30 minutes or so you feel much better. A cardiologist has been called in by the emergency physician and will assess you.

    This will very likely be the verdict: “We have to do a coronary arteriogram where I advance a thin catheter through your femoral artery backwards to where the coronary arteries originate from. We can then study each coronary artery separately and determine whether an angioplasty needs to be done.” Upon your questioning he explains that an angioplasty is a procedure where a catheter is advanced through a new clot that often forms during a heart attack and a stent is left behind that will keep the previously blocked off coronary artery open.

    Within an hour the procedure will be completed. The cardiologist will explain that he found significant narrowing, such a san 85% narrowing in the anterior descending coronary artery and a second lesion in the right coronary artery with maybe 55% narrowing. He has stented both of these arteries successfully. But he warns you that the stents may close off, if you are unable (or rather unwilling) to change your lifestyle. He also will be very specific with what he meant: Quit smoking immediately, get into a regular exercise program and adopt a strict heart healthy diet like the Mediterranean diet. They would keep you overnight just to observe your heart rhythm and blood pressure. In the morning, if everything is OK he will likely discharge you.

    Comment: Unfortunately this scenario is all too familiar to me having worked as a family physician doing my rotations as an emergency physician in a community hospital for 16 years. I found that people tended to NOT think preventatively unless they were forced to. When an acute event like a heart attack happens, a higher percentage of people is committed to prevention, but medical people call this “secondary prevention” as this prevention was only started after a close call. Our sample patient above could have developed a serious arrhythmia (irregular heart beats after a heart attack) and suddenly slipped into a coma and died before the interventional cardiologist could have placed the stents.

    Primary prevention is much more powerful and this is what I like to cover next.

    Two Approaches To Heart Disease

    Two Approaches To Heart Disease (Placement Of Stent Shown)

    2. The preventative approach to heart disease

    Most people never have to be rushed to the hospital with chest pain. They engage in various ways of “primary prevention”.  So, what exactly is this?

    They keep very active, like walking or jogging, dancing, working out in a gym, biking or swimming etc.

    They also like a healthier than normal lifestyle: eat at home as much as possible, and many adopt to buy only organic food. Why, you may ask? Organic food does not contain insecticide residues that resemble estrogenic substances (so-called “xenoestrogens” which accelerate hardening of the arteries). But organic food also does not contain GMO (genetically modified food). We know enough about GMO now to indicate to us that autoimmune diseases with inflammation of the arteries and the gut can occur. But the full impact on people’s health will not be known for several more decades. So why experiment with yourself? Buy organic instead. It is known to be safe.

    Vitamins and minerals can be very useful supplements that also prevent premature aging of our blood vessels.

    Anti-aging research has shown that with aging come various hormone defects. Melatonin is one of the first to go (in your twenties). But melatonin tables that are widely available in drug stores and health food stores can come to your rescue:  3mg of melatonin at bedtime will give you a good night sleep and provide powerful anti-oxidant effects. DHEA is an adrenal gland hormone that can be measured in your blood (or in saliva). In case it is low, it can be easily replaced with supplements. In the 50’s or 60’s women and to a lesser degree men will start to show thyroid under-functions. We call this hypothyroidism. Have your TSH and T4 levels checked and talk to you doctor about whether you need thyroid replacement, if the values are off.

    It is somewhat more difficult to explain the rest of the hormones. But you know that women get into menopause and men about 10 to 15 years later will hit andropause, which is the male equivalent of menopause in women.  An easy way to check this out is by doing a hormone panel from just one tube of spit. Yes, it is a saliva hormone panel I am talking about. For women it is estrogen, progesterone, cortisol, DHEA and testosterone that should be analyzed. For men it is testosterone, DHEA, cortisol, estrogen and progesterone. I am aware that these are the same 5 hormones, but I listed them in the order of importance for women and men. In this blog you find more details about bio-identical hormone replacement.

    I have followed a primary heart attack prevention program since 2001 and it seems to suit me well.  Just to check things out I had a carotid intima test, which showed no hardening of the arteries. Just two weeks ago my optician took images of the retinal vessels and found hardly any hardening of my retinal arteries. I scored high on a Bruce treadmill protocol in March of 2013 and my lipid VAT values were excellent indicating a low risk for a heart attack.

    I have delved into this subject in more detail in my book entitled “A Survivor’s Guide to Successful Aging” (Ref. 1).

    Conclusion

    Prevention of a disease is always better than curing a disease, this applies to heart attacks as well. While you do something good for your heart, you are at the same time preventing strokes and many degenerative conditions like Parkinson’s disease, Alzheimer’s disease. In addition you also prevent cancer. It really is a good deal!

    More information on prevention of heart disease: http://nethealthbook.com/cardiovascular-disease/heart-disease/heart-attack-myocardial-infarction-or-mi/prevention-heart-attack/

    Reference:

    1. Dr. R. Schilling: “A Survivor’s Guide to Successful Aging“. Paperback through Amazon.com, 2014.

    Last edited Nov. 8, 2014

    Sep
    13
    2014

    What To Watch Out For In Restaurant Foods

    Recently I saw a flyer of a fast food chain restaurant entitled “Food Fact”. Interestingly you get the contents of a list of bakery items, warm breakfast items, burgers, sandwiches and wraps for lunch as well as yogurt parfaits and fruit cups.

    I have to commend the restaurant chain to attempt to educate their customers by itemizing each item.  They have listed the serving size broken down into calories, total fat, saturated fat, trans fat, cholesterol, sugar, protein, dietary fiber, vitamin C, A, calcium and iron.

    Based on my dietary habits I need to check this list.

    No trans fat

    Years ago I have given up on trans fats because trans fat contain free radicals that accelerate hardening of the arteritis. Granted , the percentage is low, but 20% come from natural meats and 80% from processed foods. It is the 80% from processed foods that I avoid. Here is another review that explain trans fats in more detail. This eliminates the baked sweet pieces like croissants, cookies, raisin bran muffins, oat fudge bars and even spinach feta wraps.

    What To Watch Out For In Restaurant Foods

    What To Watch Out For In Restaurant Foods

    Total fat

    Now we come to total fat. The content list shows me that calories in total and fat content in total are closely related. But you reach the peak when you swallowed a sausage, egg and cheddar breakfast sandwich. This alone accounts for 500 calories. This is also high in cholesterol and high in sodium, so not really on my list of desirable foods.

    Sodium content

    I am now getting concerned about my blood pressure as I follow the sodium content. Who would have thought that a spinach feta wrap has more than 800mg of sodium? And ham and a Swiss Panini have more than 1500 mg of sodium? Literally 50% of the food list would not be on my menu, if I want to limit my sodium intake to 400mg or less per helping. Especially the sandwiches are out!

    Hidden sugar

    So, now I am looking at a yoghurt for a light snack,  but suddenly the sugar column has sprung up from 1-2 mg of sugar content in simple sandwiches to 37 to 55 mg of sugar for honey creek yoghurt parfait to strawberry blueberry parfait. It is not the yoghurt, it’s not the fruit, it is extra sugar, honey or high-fructose corn syrup mixed in here. This is definitely not what I am going to choose.

    Refined carbs

    Although the carbs by weight do not appear too high on the list, it is the total of sugar and carbs and the fat that has been added, which add up very quickly to hefty calorie sums in all of the foods. I am shaking my head and I absolutely cannot find anything that is healthy and would merit being eaten by me.

    Missing greens

    I am missing vegetables and salads.  The only thing I see that I can eat is their classic oatmeal, which has 160 calories with a nut medley topping. I may add a decaf-coffee sweetened with my own stevia that I brought along and some cream (because that’s how I still like it having been raised in Germany).

    Homemade food

    Then I rush to the health food store and to the grocery store and load up on organic foods, meat, lettuce, broccoli, peppers, spinach, organic olive oil and balsamic vinegar. And, yes, a tub of plain goat yoghurt. Organic walnut halves are also on the list (quite expensive, I must say).

    I suddenly realize that now I have all of the ingredients to never enter a restaurant again. I can prepare my own food and I can do it the way I want it, not how the food industry wants me to eat it.

    If I ate the food industry’s way, the salt content would send my blood pressure through the roof and I would get hardening of the arteries within the shortest time (from refined sugar, starchy foods and trans fats).

    I find the taste of home cooked meals superb. All of the flavors are there. Of course, I do not mind spending the extra money on the organic food, because the tastes are the way my grandmother’s food used to taste. I rarely add salt and my blood pressure is 105/65, so something must be going right.

    I am thinking what would happen, if more people would do what I do: avoid restaurants, especially fast food places, pack your own lunch box with an organic salad and enjoy dinner at home. It can be simple, tasty, healthy, and economical. Nobody needs to be an accomplished chef to do that. Would there be pressure on the food industry to open up organic restaurants and offer alternatives to those who want to enjoy healthy, tasty foods ?  Or are the fast food places here to stay forever and ever?

    Conclusion

    I thought I go with you today to one of those fast food places that actually list their food content. Listing it does not really help when the whole list consists almost exclusively of foods that are having serious drawbacks, be it in the addition of too much sodium, fats, sugar or refined carbohydrates.

    You do not want to get accelerated hardening of your arteries from too much fat, trans fat, sugar and starchy foods. You don’t want to get high blood pressure from too much salt day after day. You may want to rethink that processed foods are really lacking the nutrition that your body needs to function well and healthy. A lot of them are best to be thrown out. You need fresh, organic vegetables and lettuce, spinach, Swiss chard etc. Maybe you want a vegetable omelet for breakfast with egg white, spinach, peppers and Swiss chard? Take charge of your own life. Look after your own affairs. This includes what you do in your kitchen and what foods you consume.

    More information on:

    1. High blood pressure: http://nethealthbook.com/cardiovascular-disease/high-blood-pressure-hypertension/

    2. Cardiovascular disease: http://nethealthbook.com/cardiovascular-disease/

    Last edited Nov. 8, 2014

    Sep
    03
    2014

    Probiotics Are Important For Your Health

    We need to be aware that probiotics are important for your health. Growing up in Germany after World War II I remember that occasionally there were interesting newspaper headings. It  showed an older person in the nineties when the average life expectancy was in the late 60’s. The reporter asked, “What did you do to turn that old?” The answer was that the person always ate a lot of yogurt.

    This did not sink into mainstream medicine at that time and people did not really believe this statement. How could eating yogurt make a person live longer?

    Fast forward to 2014. You read about probiotics in magazines, on the Internet, and even TV commercials expose you to it.

    In the Wikipedia it is accepted that yogurt can help seniors who have a lower bifidus bacteria population in their colon to rebalance their gut flora, which will prevent colon cancer. It also describes that yogurt can help yeast infections in women.

    In the meantime probiotics have been developed and concentrations like 20 to 80 billion bacteria per capsule with a mix of Lactobacillus and Bifidobacterium species are available in the health food store for prevention.

    The medical profession has studied the effects of higher potency probiotics and came to the conclusion that probiotics have indeed effects on the body far beyond the gut.

    Here are a few highlights.

    Bowel disease improves

    In cases of bacterial or viral diarrhea the frequency of bowel movements and the intensity of bowel cramps gets helped within a few days, and recovery from the diarrhea is much faster with probiotic than without. Patient with irritable bowel syndrome and ulcerative colitis are helped with probiotics. Probiotics help both constipation and diarrhea in otherwise healthy people as well.

    Immune system booster

    The small bowel contains clusters of immune cells within the bowel wall. Together they are a formidable immune organ in the gut, which connects to the blood and the rest of the immune system throughout the body (lymph glands, spleen, bone marrow). Specifically it has been proven in humans that macrophages, natural killer (NK) cells and cytotoxic T-lymphocytes, which are the working horses of the immune system, are all stimulated by probiotics.

    Less respiratory infections

    School children who were given 1 capsule of probiotics twice per day for 3 months and flu symptoms and absenteeism were observed due to colds and flus. When they did get a viral infection, the illness had a shorter course, resulting in much less school absenteeism over the course of the trial when compared to a placebo group. It seems that a healthy gut flora stimulates the immune system to work at its best.

    Cancer prevention

    To a certain degree cancer can be prevented by probiotics and other nutritional factors. Breast cancer is one of the cancers where probiotics have been shown to be effective in reducing disease.

    Apparently the probiotic bacteria bind to the cancer causing factors (carcinogens) that some of the bad gut bacteria produce. Probiotics also suppress other bacteria that convert pro-carcinogens into carcinogens. This is not all: the probiotics also interfere with enzymes involved in the production of carcinogens in the gut. This stimulates the gut immune cells to produce cytokines that are needed in the battle against early cancer. Probiotics play a role in multiple processes that help the body to fight cancer, not only in the gut, but also in the rest of the body!

    Helps diabetes get better

    How can gut bacteria help diabetes, which is an endocrinological disease? Both human and animal studies have shown that insulin resistance is improved by probiotics. In a 6-week study both blood sugar levels and hemoglobin A1C values (that measure long-term control of diabetes) dropped significantly by eating 300 grams of yoghurt per day when compared to a control group who did not.

    Obesity

    Probiotics given to mothers at least one month prior to birth and at least up to 6 months after birth prevented excessive weight gain in both the mothers and their children. In addition, probiotics can suppress a lot of the inflammatory substances in obesity.

    Probiotics reduce cardiovascular risk

    Several studies have shown that probiotics lower LDL cholesterol, total cholesterol and inflammatory markers in the blood stream resulting in lower risk for hardening of the arteries.

    One should not look at probiotics as a single factor for prevention of heart attacks and strokes. Combine probiotics with exercise and a low refined carbohydrate diet. High sugar and starch diets lead to absorption of sugar in the stomach and small intestine. This results in a lack of nutrients to support the gut flora. Combine probiotics with vegetables and lettuce. Then you have the proper mix of fiber, minerals and other nutrients to sustain balanced bacteria in the bowels. This prevents heart attacks and strokes and keeps inflammatory markers down. I have blogged about this before and stated that the combination of organic food (to avoid antibiotic residues in our diet), fruit and vegetables combined with probiotics will protect you from heart attacks and strokes.

    Probiotics Important For Your Health

    Probiotics Are Important For Your Health

    Conclusion

    Maybe the newspaper articles in Germany after the Second World War were right. There is something in yogurt (Lactobacillus and Bifidobacterium species) that can make you live longer. The explanation seems simple: add probiotics to your diet.  You will have a better immune system and get less respiratory infections. But you also prevent heart attacks, strokes and prevent obesity and cancer. All of this in combination will lead to healthier lives, and more people will live to tell about it.

    Last edited Sept. 3, 2014

    Aug
    23
    2014

    Ebola Virus An Emerging Killer Infection

    Ebola virus has now infected about 2600 and killed more than 1400 people in its short history. That’s a mortality of about 54% overall.

    Two Americans who had been treating patients with Ebola virus disease (formerly called Ebola hemorrhagic fever) in Liberia, West Africa had been treated back in the US at a hospital in Atlanta. They have just been released as cured. They have been treated with an experimental drug called ZMapp. This is a monoclonal antibody from mice against surface components of the Ebola virus.

    At this point no safety studies on humans have been performed with ZMapp, but a recent ethics committee meeting of the WHO has determined that the emergency use of ZMapp would be ethically acceptable due to the high death rate of the disease otherwise without treatment.

    Other scenarios of killer infections

    Several decades back some of the diseases mentioned in this article were basically unknown to the general population, but in the meantime some new infectious diseases have received a lot of media attention.

    You will remember that there was an outbreak of anthrax spores by inhalation in 2001 in the US. A recent New England Journal of Medicine report points out that prior to 2001 the death rate of patients who had inhaled anthrax spores was 80% to 90% even with the use of antibiotics. However due to earlier detection and diagnosis, and due to aggressive supportive measures this epidemic of anthrax by inhalation had a mortality of only 45% toward the end or that epidemic. Had there been a new substance used that was ineffective, but harmless otherwise the reduced death rate would have been attributed to the erroneous conclusion that this new drug was effective in reducing mortality rates. This article cautions that rigid safety and effectiveness studies have to be done on ZMapp to ensure that it is a safe and effective drug to treat Ebola virus and that the reduction in death rates is truly from the drug, not just from improved supportive measures.

    Other newer infections have been Marburg hemorrhagic fever caused by the Marburg virus. This also belongs to the Filoviridae family of viruses to which Ebola virus belongs as well. Then there is the SARS virus, the cause of severe acute respiratory syndrome. Not too long ago the BSE prion, which is the virus causing bovine spongiform encephalopathy made history.

    What do we know about the Ebola virus?

    There are 5 strains of the Ebola virus, one of which (the Zaire strain) is responsible for the present outbreak of Ebola virus disease in Africa. Dr. Jon Lai who is associate professor of biochemistry at the Albert Einstein College of Medicine in New York City has developed antibodies in mice that will slow down and attack the aggressive Ebola virus when it enters the human body.

    Ebola virus disease occurs in remote villages of the rainforest in Central and West Africa where fruit bats are the natural hosts of Ebola virus. It is transmitted from local fruit bats to animals (monkeys among others), to humans and can then be transmitted to other humans. The virus is not as easily transmitted as colds or the flu. For instance, the Ebola virus does not transmit through the air, food or water. But you can get Ebola virus through skin contact, fluid contact and through needles with blood from an infected person. Also, when surfaces are contaminated with infectious body fluids and you touch this contaminated surface with your skin, the virus will penetrate through the skin and get you infected.

    There have been several outbreaks in Africa since 1976 as you can see from this WHO link.

    This link also suggests that proper hygiene measure like cleaning of pig and monkey farms with sodium hypochlorite should be effective in inactivating the virus, which makes virus transmission to humans more difficult.

    Ebola Virus An Emerging Killer Infection

    Ebola Virus An Emerging Killer Infection

    Symptoms of Ebola virus disease

    Ebola virus disease has an incubation time of 8 to 10 days where the person may complain of some tiredness, but is not sick yet. This is the time when the Ebola virus multiplies. It  paralyzes the immune system and distributes itself through the organ system.

    After these initial days of incubation there is a sudden onset of a sore throat, high fever and headaches, lack of appetite, a stomachache and weakness.

    Now the Ebola virus disease takes off and becomes life threatening as the major organs are infected with the virus, and as a result, vital organs shut down their functions. As the production of coagulation factors from the liver stops, there is major bleeding from body orifices (nose, ears, eyes, mouth, and bloody diarrhea). A skin rash develops all over the body from bleeding into the skin.

    At this point the disease gets out of control as the blood circulation collapses and the affected person dies in shock. Otherwise, if fluid loss can be corrected in time with intravenous fluids, there is the danger to die from multi-organ failure. A few persons manage to survive, if the immune system produces enough antibodies in a timely manner to inactivate the Ebola virus.

    Treatment options

    At this time there is no effective treatment against the Ebola virus disease. As mentioned earlier, ZMapp is an experimental drug that may have some merit treating Ebola virus disease in the future, but at this point it is considered experimental as human safety studies and effectiveness studies of the drug have not been completed. Any experimental treatment with ZMapp will be part of these studies for the next few years, but production issues will have to be sorted out as well as presently there is not enough ZMapp around to treat all of the Ebola virus infected people in Africa.

    This leaves us with the only preventative approach of interrupting the infectious pathway. We do know that there is a geographic zone in Africa where fruit bats, the natural hosts of Ebola virus live. It is in the same geographic zone that all of the known Ebola virus disease cases have originated from. It follows from this that it is safer for humans to live outside that zone. So do not plan sightseeing or other trips into those areas, if you value your life; I should qualify this by saying “until an effective treatment against the Ebola virus has been established”.

    Those who bury dead ones who came down with this disease must wear safety suits, which look like space suits. As already indicated, surfaces need to be disinfected with sodium hypochlorite. All of these hygienic measures interrupt the Ebola virus transmission. Quarantine measures need to be strictly enforced for those who are suspected of harboring Ebola virus disease to prevent spreading this disease into the rest of society.

    Conclusions

    Although the medical puzzle of the Ebola virus disease has not yet been completely solved, there are encouraging facts that have been learnt. The Ebola virus has been around Africa since 1976 and several outbreaks have occurred on this continent since. But spread beyond these borders has been avoided due to strict isolation practices. Even within Africa the worst cases of Ebola outbreaks have occurred mostly in villages where hygienic measures are not adhered to as thoroughly when compared to larger African cities where isolation around Ebola virus disease patients is strictly enforced by the local authorities.

    Hopefully with the emergence of an effective treatment this disease will get out of the lime light as did other killer diseases in the recent past.

    More information on Ebola virus: http://nethealthbook.com/infectious-disease/infectious-disease-infections/ebola-virus/

    Last edited Nov. 8, 2014

    Aug
    13
    2014

    Pure Water A Necessity

    Water has been in the news a lot: there has been the Toledo, Ohio incident affecting 400,000 residents because toxins of algae from Lake Erie entered into the public water system. At about the same time in northern British Columbia, Canada there was a broken dam from a mining company’s toxic wastewater reservoir spilling toxic wastewater into the Fraser River drinking water system.

    Between 60 and 70% of our bodies are made up of water. We need water for a multitude of biochemical reactions that constantly take place within us. We need water to “run the engine”. This includes detoxification of our bodies as water is a large part of our kidney excretions (urine) and still is a significantly percentage of our stools. Water is the basis for our blood circulation.

    Having said all this it is important that we insist only drinking pure water. In the following I will describe why this can be a problem and how to solve this problem.

    Brief history of water purification

    The first sand filter for water purification was developed in Scotland by a private company in 1804.

    Based on this success, the Chelsea Waterworks Company in London in 1829 was founded, which was the first public water supply in the world. When a  choleraepidemic hit London in 1854, physician Dr. Snow discovered that cholera was confined to those districts in London where water was not purified and he provided the authorities with a dot map depicting the cholera cases in London, which correlated with the water system that used no filtration methods. When the pumps were switched off in this district of London, the cholera epidemic subsided.

    Europe adopted the English model in the late 1800’s and added sewage treatment plants in order to separate wastewater from drinking water. The first sewage treatment plant was built in Frankfurt in 1887. This was necessary because of huge epidemics of cholera and typhoid fever that swept through Europe. When separation of sewage and drinking water was achieved, these epidemics stopped.

    It is interesting that minimal water standards were introduced in the US only in 1914 and it took until 1940 before water purity was legislated federally.

    Pure Water A Necessity

    Pure Water A Necessity

    Toxins in water

    Townships have to get the drinking water they pipe into your house from somewhere. Often this is a lake, an artesian well or several artesian wells combined; in the past it was from rivers, but they are now mostly contaminated with sewage and chemicals.

    There is the added problem that natural soil compositions vary tremendously throughout a country, so that arsenic is found very high in some parts of the world and the drinking water can be high in arsenic in those places.

    Arsenic is contained naturally in soils of some areas, so-called “hot spots“.

    It follows from here that some springs can also be contaminated with arsenic and other heavy metals. Heavy metals poison our internal enzyme systems and interfere with the body’s metabolism.

    A well is more likely to contain arsenic than a river or lake as a water source. But we do not only concern ourselves with toxins; viruses and bacteria are also a problem.

    Bacterial and viral contamination

    In Europe, before cities built sewage systems it was not uncommon that excrements from humans and animals found their way into the well that was used for drinking water. We like to think that we are safe now with all of the laws and measures in place, but the various news stories teach us otherwise. Common bacterial contaminants are Salmonella, E.coli (strain O157:H7), Giardia lamblia, Legionella, the parasite Cryptosporidium and others.

    In Canada there was a tragic incident in 2000 where thousands of residents of Walkerton, a small town in Ontario were exposed to E.coli (strain O157:H7). This was due to a chlorination unit that was not working, but those who were responsible for water quality maintenance were denying it and were not even properly trained to run the chlorination equipment.

    Water testing

    Water testing is at the beginning of any water purification system and intermittent ongoing testing is at the center of monitoring water quality on a permanent basis. Water inspectors need to constantly monitor the water source, the water purification process and the delivery system.

    Many people in rural Canadian or US towns depend on well water. The same logic is true for water quality with regard to well water as it is for municipal water; just it is on a smaller scale.

    You want to know what your water is like. It is not difficult to find out: take a water sample and have it analyzed at a water company. Depending on the result the water company will advise you what kind of filter you will need.

    The first purification stage typically is an activated carbon filter that removes organic compounds, radon and other impurities. Every three or four days the filter automatically backwashes and cleans itself for about 45 minutes. Once a year the activated carbon has to be removed and replaced by a new filter. This type of filter is also useful for people who are on municipal water, but want to remove the halogens (fluoride, bromide, chloride) used to disinfect municipal water.

    The second stage is an ultraviolet irradiation device. This disinfects the water just prior to coming to your water tap from any bacteria, viruses or parasites.

    It is recommended that you also install a reverse osmosis system under your main kitchen sink. It will provide you with purified drinking water. Water produced by this filter goes through additional activated carbon filters and finally must pass through a porous membrane where only water can pass through, but heavy metals and other impurities will not. During an outbreak of Cryptosporidium in 1996 in Kelowna, BC those who had a reverse osmosis system were safe from this pathogen.

    You can brush your teeth with confidence with reverse osmosis water, even if your drinking water is contaminated.

    Proper water purification

    If you are on municipal water, find out what system the municipality is using to ensure water safety. Usually there is a first step of a slow sand filter, where the raw water is first purified, then it undergoes a water chlorination, bromination or fluoridation process, which is done to remove bacteria and viruses. We know, however from a series of outbreaks of Cryptosporidium gastroenteritis cases in municipalities that only used this two stage purification process, that a third step, namely ultraviolet germicidal irradiation, is also necessary to eradicate this microscopic parasite.

    Cryptosporidium was the problem behind a drinking water problem in the summer of 1996 in Kelowna, BC, the town of the interior of BC, Canada where I live. 50,000 residents had to get their drinking water from water trucks that were parked at certain locations of the town (about 40% of the population was affected by this water problem). Kelowna now has a modern ultraviolet irradiation system in place.

    Immune system compromised people

    People whose immune system is compromised such as AIDS patients or patients who had chemotherapy for cancer are very susceptible to Cryptosporidium and other parasites, bacteria and viruses. For them it is particularly important that the third stage, the ultraviolet irradiation step be part of the municipal water treatment process. If this is missing, have a home unit installed by a water company.

    Conclusion

    It is interesting to see how in Europe the history of water purification has been tightly linked to the history of cholera and typhoid fever epidemics; the quest for learning from these mistakes of the past has brought new solutions. The mistake in the past had been that in water sources wastewater contaminated the drinking water sources. To our modern thinking this seems unimaginable. But recent events that we read about in the news remind us that we cannot be lax on water purification. It is a reality that the same mistakes from the past are still sporadically made now! Know your water source; know the water quality of the water you brush your teeth with (for instance use only bottled water for this in Mexico). Remember that in many development countries to which you may travel there is no clear separation of drinking water and wastewater and there may not be a three-phase filtration system in place that I described above.

    Enjoy drinking your clean, refreshing clean water until I meet you again in another blog.

    More information on gastroenteritis (from unclean water): http://nethealthbook.com/digestive-system-and-gastrointestinal-disorders/gastroenteritis-food-poisoning/

    Last edited Nov. 8, 2014

    Aug
    02
    2014

    Keep Your Muscles In Older Age

    Intuitively you may have noted that older folks who have very little “meat” on them are not as healthy as people of the same age with well-developed muscles.

    A research team under the supervision of Dr. Preethi Srikanthan and Dr. Arun S. Karlamangla from the David Geffen School of Medicine at UCLA, Los Angeles, CA decided to measure the muscle mass index instead of the body mass index. They did this using bioelectrical impedance (simple electronic body composition bathroom scales) and they wanted to see whether there would be any correlation with regard to mortality statistics in an older population.

    The study group consisted of 3659 participants from the National Health and Nutrition Examination Survey III (average age for males 55 and older, females 65 and older). The survey took place between 1988-1994. Mortality rates were computed by the end of 2004. The median length of follow-up per person was 13.2 years.

    The authors of the study compared mortality curves for four subgroups of muscle mass from low to high: 0-25%, 25-50%, 50 to 75% and 75 to 100%. When the lowest muscle mass group was compared to the highest muscle mass group, there was a 20% increased mortality rate for the lowest muscle mass group.

    This study had careful controls built in and could demonstrate that the difference was not due to better or worse LDL cholesterol values or triglycerides; it was not due to differences in diabetic rates or other factors. This is the first study that shows in a US based population that a lower than average muscle mass is an independent risk factor for premature death in an older population.

    The authors were aware of Danish study that had previously shown that a lower muscle mass was associated with a higher mortality rate in 50 to 64 year-olds.

    I like to comment regarding this study by putting it into the context of other medical findings.

    Keep Your Muscles In Older Age

    Keep Your Muscles In Older Age

    1. Older people tend to have more falls

    Several studies have shown over the years that older people fall more often because of a combination of balance problems with slower reaction time, and also because of poorer muscle development when compared to a younger age group. The medical costs are staggering when older people reach the age of 85 where about 20% of that subpopulation experience serious falls resulting in hip fractures and hospitalizations. There is a mortality of about 25% associated with hip fractures in that age group. And about 50% of those who survive will not be living independently at 1 year following a hip fracture. Fortunately fractures from falls can largely be prevented by making physical changes to the home to prevent tripping and having extra guard rails where needed. But another important factor is to exercise regularly within the capabilities of the older person to maintain muscle mass, which will balance the body and control upper and lower extremity strength as the person moves around.

    2. Fit people live longer

    A Stanford University study followed 6000 middle-aged men for 10 years and found that the fittest who exercised regularly were 12% more likely to stay alive for every metabolic equivalent; this is the energy that a sitting person uses in terms of oxygen consumption. They also found that the least fit had a 4.5-fold higher death rate within 6 years from the beginning of the study compared to the fittest.

    To put this into perspective: a regular walk at less than two miles an hour would be equivalent to 2 metabolic equivalents, a brisk walk at 4 miles per hour is worth 5 metabolic equivalents and running 6 miles an hour is worth 8 metabolic equivalents. This is how the math works: a regular walk every day translates into 2×12% = 24% more likelihood of staying alive in the next 6 years compared to a sedentary person. A person exercising with a brisk walk with a speed of 4 miles per hour every day would be 5×12% = 60% more likely to be alive in 6 years compared to a sedentary person who does not exercise. Not smoking and having a normal weight would add to your probability of living longer. Pushing yourself to the extreme (running 6 miles per hour) may be problematic for the majority of us as there are issues of getting into adrenal gland insufficiency that can develop, if you over-stress yourself. (This is my comment, not part of the study).

    Now you may have wondered about the woman’s side (as the previous study was an all-male study). The answer comes from a recent paper that studied 10 clinical trials throughout the world (US, Denmark, Germany, Sweden, Taiwan and Japan) involving only postmenopausal women. Yes, there is the same surprising finding that regular brisk exercise makes the women live longer with less disabilities and less mortality!

    The bottom line: exercise regularly and live.

    3. Exercise develops your muscles and maintains them

    We were born to use our muscles daily (designed as hunter/gatherers), but in the meantime this is what we do: sitting in front of the computer or TV, in cars, in class (school, university, work) or in the movie theatre. So we need to discipline ourselves to get into a routine that balances all of the other activities. Muscle strength exercises or activities as indicated in this link are the answer.

    The earlier we adopt this type of a routine, the better off we are when we reach the golden years of retirement. I am one of the examples of former non-exercisers. Apart from liking to go for long walks 3 to 4 times per week I did no formal exercises until 8 years ago when my wife and I got into ballroom and Latin dancing inspired by “Dancing with the stars”. But it is only about 2 years now that we took up regular gym workouts for 45 to 60 minutes every day. It is now easier for me to walk up on a steep hill in our neighborhood that has an 18% incline than 2 years ago.  Muscles need regular exercise. You put a limb in a cast and within 3 weeks most of the muscle strength has melted away. You remove the cast and it will take 3 to 6 weeks of regular exercise to regain the muscle strength. So why not maintain your muscle strength in the first place?

    4. Exercise develops cardiovascular fitness

    The aerobic part of my daily exercise program (treadmill) develops cardiovascular fitness as the lungs have to work harder and the heart is being activated. Doing this regularly is mimicking going through the landscape looking for food and hunting.  Of course most of us drive in our cars to the grocery store and get our food that way. So my balance is to go to the gym and at least once a day get that work-out. What can we expect from fitness training? An NIH study showed that with a moderate work-out of only 2.5 hours per week you will gain 4.5 years of life due to cardiovascular fitness. This is better than money in the account. It is free healthy additional life!

    5. Sensible nutrition will help preserve muscle mass

    No, I am not taking your food away. I am suggesting that we watch the quality of the food we are consuming. If you are like the average consumer, you may be eating too many carbs in form of pasta, bread, rice and potatoes. Some of you have read in past blogs that my wife and I cut out sugar and starchy foods as well as wheat since 2001. We both lost 50 pounds and kept it down. I know that if I would restart sugar and starchy foods, my fat content would go up, my muscle content down and the BMI up. How do I know? I weigh myself every day on body composition scales (which works by the principal of bioelectrical impedance analysis), which show all of these indicators. Recently I got into some organic Bing cherries. They were delicious, but it also is a fruit with significant sugar content! Within a day I knew that I’d better watch the quantities I consume (fat composition was up, muscles mass down). It took 3 days for my values to be back to normal.

    When it comes to muscle mass, overconsumption of refined carbs is one problem; however, our bodies do need quality lean meat and some fish (salmon, mackerel; low mercury fish) as a source of protein. I buy organic meats to get away from the problem of pesticide pollution as much as possible. Some people like vegan food, they may need to supplement with protein supplements.

    Conclusion:

    It may sound like common sense that a body with well-developed muscles will live longer. You may want to compare this to a well-maintained car (less rust, good maintenance) and the car will still drive well once it has a high mileage.

    We have bodies that need maintenance (exercise) and good nutrition (no junk food, sensible diet). If we make this our regular lifestyle, we will develop and maintain muscles. It will keep us in the group with a lower mortality rate compared to sessile persons and junk food consumers.

    Nothing happens without any effort. We need to earn muscle fitness for ourselves! Think about it, improve where you need to improve and then maintain it. More than anything else this will pay dividends well into your future.

    More information on:

    1. Exercise (fitness): http://nethealthbook.com/health-nutrition-and-fitness/fitness/

    2. Arteriosclerosis (hardening of the arteries and how to avoid it): http://nethealthbook.com/cardiovascular-disease/heart-disease/atherosclerosis-the-missing-link-between-strokes-and-heart-attacks/

     

    Last edited Nov. 8, 2014

     

    Jul
    23
    2014

    Sunburn Prevention

    Much has been written about sunburn prevention. The thinking behind this is that perhaps we could prevent skin cancer and melanoma development, if we would block ultraviolet rays from the sun or from tanning booths irritate our skin.

    So far the theory. Now the truth.

    1. Increase of skin cancer despite sunscreen applications

    It is sobering that statistics of skin cancer frequency  show that despite more awareness of the importance of skin protection with sunscreen lotions and creams, skin cancer rates have steadily increased. Behind this paradox is the fact that vitamin D3 production in the skin is blocked from sun exposure and the person is not getting the cancer protecting effect of vitamin D3.

    Low vitamin D3 levels (measured as 25-hydroxy vitamin D3) are not only associated with skin cancer, but also with breast cancer, and breast cancer will be reduced to 50% of control groups, if patients are treated with high vitamin D3 supplements. There are many other cancers that respond to exposure to sunlight or to supplementation with vitamin D3.

    2. We need to know about infrared rays and the ultraviolet exposure

    The ultraviolet radiation of sunlight has been extensively studied. There are UVA rays that range from 315 to 400 nanometers. They make up about 95% of the sunlight and penetrate deeper into the skin (the dermis level) leading to more severe skin damage, producing aged looking skin.  UVB rays (5% of sunlight) contain wavelength measuring between 280 and 325 nanometers affecting the most superficial layer of the skin, the epidermis. These rays cause sunburns. Both UVA and UVB are strongest around midday. The sun also produces UVC rays (wave length 180 to 280 nanometers), which are completely absorbed by the ozone layer and are not of importance unless you live under an ozone hole.

    Next there is IR (infrared radiation), which has only recently been detected to be of health concern. IR rays range from 760 nanometers to 1 million nanometers (=1 millimeter). It causes skin photoaging and damage. Most of IR is in the lower range (between 760 and 1,440 nanometers); the total amount of IR rays that reach the skin is massive compared to the UV light and 50% of these rays reach deep into the skin to the level of the dermis.

    Sunburn Prevention

    Sunburn Prevention

    3. Filtering out the damaging rays

    Armed with the above knowledge we can now talk about sunscreen lotions and sunscreen creams. Traditional sunscreen lotions and creams have been directed against both shortwave (UVB) and longwave (UVA) rays of the sun. UVB blockers prevent damage to the surface of the skin (epidermis level), UVA blockers prevent damage to the deeper dermis. It is in your interest to buy a sun blocking agent that blocks both of these rays. (You have to read labels.)

    However, both of these blockers, which means all of the traditional sunscreen agents, will not block IR waves (infrared radiation), which causes most of the wrinkles, age-related skin changes and skin DNA damage, which eventually results in skin cancer.

    4. Vitamin D3 deficiency because of sunscreen applications

    As we know that sunscreen agents lead to blocking of vitamin D synthesis in the skin, it is prudent to take vitamin D3 5,000 to 10,000 IU per day and have your health care provider order 25-hydroxy vitamin D3 blood levels from time to time (aim for a level of 100 ng/m or more). There is no danger of overdosing vitamin D3. That story about overdosing of vitamins is coming from vitamin A overdosing. There is a ceiling not to be exceeded due to liver toxicity over vitamin A overdosing, but not so for vitamin D3. Vitamin D3 protects not only from skin cancer, but also from other cancers. For more on vitamin D3 read my recent blog on this.

    5. Whole body protection from the inside

    There are two approaches to using systemic natural extracts. One component is from a tropical fern (Polypodium leucotomos) and another one from blood oranges that can both repair sun damaged skin and prevent sunburn. The effective substances are administered orally.

    This fern extract has been tested in smaller clinical trials and was found to have a 70% to 75% efficacy in blocking all sun rays from the inside out.

    In a small trial patients were exposed to UVB light after preparation with red orange extract and a 35% reduction of sun burn was found within 15 days when compared to controls.

    There is a possibility now to take one capsule with tropical fern extract mixed with red orange extract and combine this with traditional sunscreen agents and have optimal sun protection.

    One trial that is mentioned in these last two links is a group of polymorphous light eruption patients who are born with extreme sun sensitivity, but reported an 80% improvement with this oral fern extract treatment.

    6. Final recommendations for sunburn prevention

    Although the advice given in this WebMD link is useful, it neglects to recommend to supplement with vitamin D3 because of the sunscreen action. It also does not mention the IR waves of the sun that do most of the damage and that only get prevented by staying out of the sun or by taking the oral sunscreen pill (tropical fern extract and red orange extract mixed).

    My recommendation, if you were not allergic to ferns, is to consider taking the oral pill (as far as I know currently only available from LifeExtension as “enhanced fern block with red orange complex”) to block the entire wavelength of the sun rays. This will repair some of the skin damage that has already been done. Follow the above WebMD link as well with regard to the sun screen lotions/creams. Also stay out of the noon sun between 11 AM and 2 PM. Take your vitamin D3 in the high dose range as discussed above to preserve optimal resistance against all kinds of cancers including skin cancer.

    Conclusion:

    In reviewing the facts prior to writing this blog I was quite bewildered how misleading a lot of the literature is regarding prevention of sunburns, particularly by assuming that all you had to do was to block UVB and UVA rays. I attempted to explain why this is an oversimplification, and the skin cancer statistics clearly show that sunscreen blockers alone are not stopping skin cancer. So, we do need a combination of
    1. Staying out of the noon sun.

    2. Using clothing and wide sun hats to keep the sun out of our faces.

    3. Use the traditional sunscreen agents. Reapply, if necessary.

    4. Using an oral sunscreen agent that blocks infrared rays as discussed under point 5 and 6.

    5. Using vitamin D3 in high doses as discussed under point 4 above for cancer prevention.

    With this in mind, enjoy the rest of your summer!

    More information on:

    1. Sunburns: http://nethealthbook.com/dermatology-skin-disease/sunburns/

    2. Different skin types and skin cancer causes: http://nethealthbook.com/cancer-overview/skin-cancer/causes-skin-cancer/

    Last edited Nov. 8, 2014

    Jun
    21
    2014

    Older Grumpy People Have Higher Risk Of Dementia

    Although in this recent study from Finland researchers found that grumpiness in older age seems to lead to dementia at a faster rate, I like to emphasize here that there may be an under lying problem of hormone deficiency.

    Other studies have shown that in males low testosterone levels are associated with grumpiness and dementia is setting in sooner in those males who are deficient for testosterone. For older grumpy females it is the lack of progesterone that has been found to be deficient and when you replace it, memory comes back, symptoms of menopause reverse themselves and the grumpiness is gone. Testosterone replacement may be required by as many as 1 in 4 men in the their 40’s as is summarized in the article from Great Britain.

    How can we tell whether there is a change in an older man? There are quite a few symptoms that can be seen by loved ones around this man: an increase in abdominal girth, shrinking muscles, lack of energy, irritability. The key is to get him to the doctor and ask the doctor to order a bioavailable testosterone blood test.

    According to medical research 84% of men and 62% of women in the age group of 57 to 64 have been sexually active in the previous 12 months. Take an older age group of 65 to 74 and still 67% of men and 40% of women are sexually active. Fast-forward to age 75 to 85 and the rate has dropped to 39% of men and 17% of women (Ref.1). A person’s sexual activity is a barometer how well the hormones are balanced. These figures show that bioidentical hormone replacement has not been well accepted. Women have a reason as they were misled by Big Pharma as was shown in the

    Older Grumpy People Have Higher Risk Of Dementia

    Older Grumpy People Have Higher Risk Of Dementia

    Women’s Health Initiative:

    The National Institutes of Health had funded a large study (the Women’s Health Initiative) to clarify what was going on with regard to side effects and effects of HRT.

    Unfortunately, synthetic non-bioidentical hormone products were used in these studies (Premarin and Provera) instead of bioidentical estrogen and progesterone. The results of the Women’s Health Initiative were devastating. In 2002 doctors were warned that Premarin and Provera used as HRT would cause increased heart attack rates and breasts cancer, which led to premature death. Overall the placebo group did better than the experimental group and this is why the trial was prematurely stopped.  As a result of the wide publicity regarding the negative results of the Women’s Health Initiative postmenopausal women either do not see their physician for hormone replacement or are advised by conventional doctors that only small amounts of Premarin could be used for not more than 5 years for fear of causing breast cancer. Medico-legal considerations are at play and the whole issue of HRT after menopause has been politicized.

    Problems now for HRT:

    It is like a negative shadow has been cast forward with regard to hormone replacement because of the Women’s Health Initiative. People are still confused and don’t understand that the synthetic hormone-like drugs from Big Pharma are like an ill-fitting key for the hormone receptors in the body whereas bioidentical hormones are the perfect fit.

    Otherwise there would not be a 45% drop-off (from 62% to 17%) in sexual activities in women from age 60 to 80. Men have it somewhat easier: their drop rate between age 60 an 80 is also 45% (from 84% to 39%), but as they entered into male menopause 10 to 15 years later than women did with menopause, their sexual activity is still double that of women at the age of 80.

    However, if people could overcome their unrealistic fear of bioidentical hormones, hormones that fit the body’s hormone receptors a lot more people would be encouraged to use bioidentical hormone replacements.

    What, if the grumpy, old man is willing to see his doctor?

    The doctor should look at all of the hormones including a fasting insulin level as hyperinsulinism often complicates hormone replacement. Thyroid, which often is also lowered at an older age should be also tested (T3, T4 and TSH). A saliva hormone test can show a panel of 5 hormones: cortisol, DHEAS, testosterone, progesterone and estradiol. As hormones are in a balance with each other this allows to compute the testosterone to estrogen ratio, which ought to be 20 or higher. But hormones alone are not the answer. There needs to be a combination of proper nutrition (cut out sugar, starchy foods, preferably switch to organic foods to escape the xenoestrogens that foul up your hormone balance), also exercise and use vitamins and supplements. I have summarized all of this in my recent book “A survivor’s Guide to Successful Aging” (Ref.2).

    When the hormone tests come back the doctor will likely order the missing hormones (hopefully as bioidentical hormones).

    It can take 2 to 3 months before the full effect of bioidentical hormone replacement is seen. But most men will be astounded how well they can feel. He will notice that he does not tire with exercising. His muscle mass builds up; his posture improves. His stamina comes back. He will find that the previously foggy thinking is gone and his thought processes have become clear again. And yes, his sex live comes back. So now he has to talk to his sex partner about her bioidentical hormone replacement so they both can enjoy the benefits!

    Hidden benefits of bioidentical hormone replacement:

    The bones become stronger, the heart beats harder and better, the brain thinks clearer, because the key organs like the brain, the heart and the bones have the appropriate hormone receptors (in both sexes).  No, this is no exaggeration. This can be measured by an exercise tolerance test (for the heart). Bone density can be measured and has been done (2% to 4% increase per year). Brain function is indirectly visible to the people around the person: apart from new vitality, improvements in mood and more energy, the grumpiness is gone and the person is perceived as a pleasant person once again.

    Conclusion:

    The observation of an “old, grumpy man” when he entered the male menopause is accurate, but should not distract from the fact that he has a responsibility to look after himself. It is important to recognize that it is not only women who enter the menopause, but that men 10 to 15 years later will do the same. Both sexes enter a state of hormone disbalance that is treatable. The answer is to replace the hormone deficiency with the missing bioidentical hormones.

    More information on male menopause (=andropause): http://nethealthbook.com/hormones/hypogonadism/secondary-hypogonadism/male-menopause/

    References:

    1.Rakel: Textbook of Family Medicine, 8th ed., copyright 2011 Saunders

    2.Dr.Ray Schilling: “A Survivor’s Guide to Successful Aging“, Amazon.com, 2014

    Last edited Nov. 8, 2014

    Jun
    11
    2014

    Multiple Myeloma Cured With Measles Vaccine

    Introduction

    This article is about “multiple myeloma cured with measles vaccine”. For example, Mayo Clinic physicians were desperate when two patients with end stage multiple myeloma, a vicious bone tumor, did not respond to chemotherapy. With this in mind they tried something unconventional: high doses of the measles vaccine in an attempt to stimulate the immune system.

    Canadian researchers had reported in 2011 that oncolytic viruses created by genetically modifying smallpox vaccine viruses would enter tumor cells of patients, but not damage normal cells. A high percentage of the end stage patients responded with tumor regression.

    Use of modified measles vaccine

    Now the Mayo Clinic clinicians used high doses of a modified measles vaccine. That is to say that this attacked the multiple myeloma cells of two end stage patients. It worked on at least one patient who was cancer free after a recheck of the bone marrow 6 months later. In addition, the other patient experienced a significant remission, something not heard of in an incurable end-stage condition. Here is the story as reported recently in the press. By all means, this research is a new beginning for cancer researchers as in the past the general thinking was that physicians must fight something as bad as cancer with something strong and toxic to get rid of the cancer cells. Chiefly, the emphasis was on “fighting the cancer cell”.

    Stimulation of the immune system

    Now the emphasis is to stimulate the immune system, which will fight the cancer much better. As a past cancer researcher I would say that it is about time to take this new approach as the old approach of attacking the cancer cell like an enemy with radiation and chemotherapy did not work well. The new thinking is: why not stimulate the immune system to such an extend that it becomes newly activated, but to such a degree that there is no chance for the cancer cells to fight back. I searched the recent literature on PubMed regarding this topic and came across several other interesting human clinical trials. They are all smaller, but very encouraging. Here is a brief summary of what I found:

    Multiple Myeloma Cured With Measles Vaccine

    Multiple Myeloma Cured With Measles Vaccine

    Various cancer types

    1. Prostate cancer vaccines

    In this article a review of the use of various vaccines with dendritic cells, viruses, or DNA are described directed against the prostate-specific antigen on the surface of prostate cancer cells. 

    2. Pancreatic cancer

    This cancer is very difficult to detect in the early stages and as a result the outlook for chemotherapy or radiotherapy is extremely poor. Doctors have tried several approaches as an alternative. Immunotherapy is an option and the Mayo clinic researchers have already announced that the measles vaccine approach will likely be applicable to pancreatic cancer treatment as well in the near future. However, other clinical trials are on the way to use other vaccination procedures.

    3. Cervical cancer

    The HPV (human papilloma virus) vaccine is targeting patients exposed to the high-risk HPV16 strain most often causing cervical cancer. However, researchers have noticed that in some cases a phenomenon called the “HPV immune escape” has allowed in some vaccinated women to still develop cervical cancer. A group of researchers investigated how improvements of the vaccine can trick the immune system to attack the HPV virus.

    4. Brain tumors (glioblastoma multiforme)

    This deadly brain tumor has a survival rate of only 15 months with conventional combination therapy. However, new anti-tumor vaccines are being tested in clinical trials, which already have shown much less toxicity than conventional therapies and they have longer survival times.

    5. Melanoma treated with special vaccine

    In the early 1970’s the anti tuberculosis vaccine BCG was used to find that about 25% of patients had long-term survival advantages with this adjuvant treatment. Recently several smaller clinical trials involving end stage melanoma patients utilizing various vaccines showed encouraging results with tumor regressions. Melanoma is a particularly vicious dark skin tumor. And yet, when messenger RNA (mRNA) was combined with dendritic cells and made into a vaccine, the antigen presenting T-cells that previously did not react against the melanoma tumor suddenly became very active destroying the tumors. This line of immune treatment is very promising and clinical trials continue to go on.

    6. Another multiple myeloma treatment approach

    Apart from the measles vaccine approach mentioned at the beginning of this blog, there is another approach that is being pursued at the Ohio State University Comprehensive Cancer Center where immune cells of patients with multiple myeloma are being modified in tissue culture to be more aggressive against a CS1 marker that is expressed on the surface of 95% of multiple myeloma cells in patients with this deadly cancer.  Researchers modified T cells and grew them in culture. Subsequently physicians injected them back into patients. In mice this research team found that 100% of animals with these CS1 activated T lymphocytes were alive at 44 days after the start of this treatment. This compares favorably with 29% and 17% of two control groups. Researchers are starting a phase I clinical trial on patients with this method.

    Conclusion

    Several of the clinical trials on humans seem to be showing breakthroughs with better survivals than in the past. In addition it is also encouraging to see that these new treatment modalities are non-toxic treatments. They compare very favorably with traditional chemotherapy and radiotherapy methods. Mouse or other animal species may be a good first screening method. But there is a recognition among cancer researchers that the ultimate goal is to treat human patients. This means that cancer researchers need to concentrate on human cell lines and work with cancer patients. It will be interesting to see the outcome all of these trials and new approaches; hopefully we will see better survival rates for these patients in the near future.

    More information on multiple myeloma: http://nethealthbook.com/cancer-overview/bone-cancer/multiple-myeloma/

    Last edited Nov. 8, 2014

    May
    31
    2014

    Industry Sponsored Diet Soda Study Deceptive

    Recently an industry sponsored study was reviewed by the media with this headline: “Diet soda helps weight loss, industry-funded study finds”. Before you get too excited about this study, let me tell you that you are being deceived. Essentially the study compared 150 overweight or obese people on water and a similar group of people on diet sodas. Both groups were counselled on the benefits of exercise and a healthier diet. At the end of 12 weeks the water group that did not drink diet sodas had lost 9 pounds, while the diet soda group that continued their former habit lost 13 pounds. The question now is why this 4 pound difference? The sponsor of the study would like you to think that the soda diet drink is healthier, because it helps you to lose weight. Let me explain to you that there are a few flaws in the study as follows.

    1. Most often there are confounding errors in industry-sponsored studies. Even though it looks on the surface that the two groups were comparable, researchers should have checked out various parameters like sex distribution, other underlying illnesses, mental state (depressed or not etc.), diabetes and other factors to make sure that there is no metabolic bias between the two groups from the start of the study.

    2. Deception built into study: we know from other studies that on the long-term diet sodas lead to weight gain by stimulating your appetite for sweets and their subsequent consumption. Often short-term studies show the opposite effect, so it would be false to assume that long-term results would be similar. But most readers who read this quickly would be tempted to think “so it must be OK to continue to consume diet soda drinks!” Off you go to the grocery store and buy another 6 or 12 pack. That’s exactly what the industry-sponsored study set out to do. Somewhere in the back-room of a big soft drink corporation the executives discussed among themselves that their statistics were bad; the sales of diet soft drinks were down; there was too much negative press fuelled by the health food industry. They had to do something about this, so they designed a study where the good guy was the diet soft drink. If the consumer is not buying the results, at least the study helped to confuse people and whenever there is confusion, at least part of the confused population will return to their old habits. After all the study showed “ it is OK”.

    Industry Sponsored Diet Soda Study Deceptive

    Industry Sponsored Diet Soda Study Deceptive

    3. Excitotoxins are not OK. Unfortunately all artificial sweeteners are toxic to your brain, they are excitotoxins. MSG is another excitotoxin. The only exception is the natural sweetener stevia, a plant product, which is OK. Splenda is an insecticide, so this is belongs to the xenoestrogens, bad for you as it acts like a foreign estrogen and has cancer-promoting qualities when exposed to it for several decades. The rest of the artificial sweeteners are excitotoxins: they burn your brain cells very slowly and can lead to dementia. Unfortunately they are addicting and your brain will make you feel good when you drink more of it. So, the real reason why the study group on diet sodas did better than the water group is because they did not have to change that habit, there was no withdrawal to deal with and they felt fine. So they could concentrate on dieting and exercising and of course you would lose 13 pounds in 12 weeks doing that. The water group on the other hand had to cope with diet soda withdrawal and on top was challenged by an exercise and weight loss program. As there was no diet restriction, they could compensate a bit for their trouble of withdrawal and eat a few muffins or some extra bread to make up for the lack of their comfort diet drink fix (the satisfaction of consuming the excitotoxin). This slick short-term study design is what should have alarmed the publisher to ask a few hard questions.

    4. There needs to be an internal logic in the study: Let’s do a thought experiment where we repeat the study and start with two comparable overweight/obese groups of people and put them on no sugar and no refined carbs for 2 weeks and also on no diet sodas for the same time. After two weeks they are both accustomed to this diet and the no diet soda habit and they have probably lost the same amount of weight from the calorie restriction. Now we start the one group on diet sodas and the other group on water, but strictly controlled for a similar calorie intake in terms of other foods or drinks as much as is humanly possible. I would predict that after 12 weeks the water group will have at least lost the same weight as the diet soda group, if not more. The diet soda group likely will have had some problems with sugar craving and may have had more dietary indiscretions (sneaking in snacks and underreporting them), but this would show up as weight gain.

    You may be proud of having completed this well controlled study. The trouble is that your industry sponsor that produces the diet drinks will not like this outcome and would not allow the results to be published. In fact that kind of result would be actively suppressed.

    Conclusion:

    The diet soda study discussed here is a lesson in biased publishing. We are constantly bombarded by an endless string of meaningless publications that are designed to make the consumer insecure, or bias us for accepting a company’s product in the hope of achieving a certain result (like high sales). Even, if this is not accomplished the company has sold enough of their product just for giving it a try. Beware of the door-to-door sales person. This figure is very much present right in this publication. In this case it is the sales pitch of the diet soda manufacturers! You are looking at a study that was designed to make you buy more of the excitotoxin (aspartame or other artificial sweeteners), which likely contributed to your extra weight or obesity in the first place. It’s up to you to shut the door on this sales pitch. Instead of a diet soda I suggest you make your own drink: squeeze half an organic lemon and top this with mineral water of your choice. Sweeten it with a tiny amount of stevia. This has no calories and does not stimulate you to eat more sugar and starchy foods; but it quenches any thirst and you even get some water-soluble vitamins in the process.

    Last edited May 31, 2014