Oct
01
2006

Antiviral Drugs Not For Flu Prevention

By | Infectious Disease, Lung Disease, Prevention

With the arrival of the fall and winter season concerns about viral illnesses crop up. The most common ailment is the flu, which occurs seasonally. Prevention measures come in the forefront, and over-the-counter remedies and herbal supplements make their appearance.
Yet at this point the most effective measures remain very basic: good hygiene, hand washing, non-exposure to people who have the flu and non-sharing of personal items that could carry the virus. Flu shots for flu prevention remain the single most effective way to prevent widespread epidemics.
Antiviral agents zanamivir (also known as Relenza) and oseltamivir (Tamiflu) have come under discussion. They have been very effective in the treatment of influenza symptoms. It is not too late to treat with oseltamivir after the patient has been infected with the flu, as the drug prevents lower respiratory tract complications. For the symptomatic relief of influenza 75 mg per day were 61% effective, and 150 mg were 73% effective. Using the drugs strictly as a prophylaxis proved to be a fallacy. Results showed that neither zanamivir nor oseltamivir prevented influenza-like illnesses.

Antiviral Drugs Not For Flu Prevention

Antiviral Drugs Not For Flu Prevention

Even though both antiviral agents are not 100 % effective, they still can be useful in the setting of a flu pandemic. They are also of help in population groups with chronic health problems or immunocompromised persons to whom any viral infection can be serious.

More info about the flu: http://nethealthbook.com/infectious-disease/respiratory-infections/flu/

Reference: The Medical Post, September 1, 2006, page 61

Last edited November 1, 2014

Jul
01
2006

Avian Flu Threat Exaggerated

By | Health, Infectious Disease, Lung Disease, Prevention

Disconcerting headlines about avian influenza has caused widespread concern. Warnings have been issued to brace for an onslaught of a pandemic that could paralyze and decimate entire nations. Countries that showed cases of avian flu were scrutinized closely. Travel stopped to areas where poultry was affected. Despite reassurance to the consumer, buyers felt unsure about choosing chicken for dinner. It has been stated before, that at this point the virus of the avian flu has not made a mutation, and it is not passed from human to human. It can be transmitted from diseased fowl to human who are in close contact with the diseased animal.
The word pandemic seems to trigger a response of fear, but it has to be mentioned that a pandemic is not new. It is universally accepted that there have been 3 pandemics in the 20-th century. Pandemics are defined by an increased number of influenza deaths. One influenza wave hit in 1968, prior to this the year 1957 showed a similar picture. Pandemics are not all equal. The outbreak of influenza in 1918/19 was severe, and young and old were affected alike. Death was in many cases due to the primary viral infection.
In the meantime flu preparedness is much more common than in previous years. Flu shots are available, antibiotics can help treat secondary infection, laboratories are working on vaccines for new influenza strains, and lately antiviral medications have come into the picture.
While the work of scientists is invaluable, in some cases the statements are too simplistic. The avian flu virus H5N1 could mutate. Looking at the facts, the virus has been around since 1997, and it has not mutated. Reporters write stories about possible future pandemics, and there is worry in the population. They need to know the truth! The truth is that we should plan. The truth is also, that a pandemic is not more imminent today than it has been since 1918. In fact it is not more imminent than a multitude of other emergencies. The outbreak of SARS has shown that it is the front-line public health and hospital staff that handles the virus most of all. The production of vaccines and a strong vaccination program is being worked on. This does not leave the rest of the population with nothing what they can do.

Avian Flu Threat Exaggerated

Avian Flu Threat Exaggerated

Good hygienic measures have to be followed. The most important one (and often neglected one) is hand washing. It does not stop a pandemic like the one in 1918/19, but it certainly makes a difference to annual influenza rates. The annual vaccination against influenza is a highly effective weapon against the influenza outbreak that happens every year, and improved vaccines will make a difference between wellness and the opposite!

More information about:

The flu: http://nethealthbook.com/infectious-disease/respiratory-infections/flu/

The swine flu: http://nethealthbook.com/infectious-disease/respiratory-infections/swine-flu/

Reference: The Medical Post, June 20, 2006, page 47

Last edited Nov. 1, 2014

May
01
2006

Avian Flu Needs Preparedness Instead Of Panic

By | Infectious Disease, Lung Disease, Prevention

Nobody can predict when the next pandemic will hit and whether it will be from an avian flu, but Canada and other countries are not taking any chances. The feds have commissioned a mock vaccine that can be adapted to whatever strain comes along. The Canadian Public Health Agency is also calling for alertness to patients coming back from countries where avian flu has occurred, especially countries with human cases. Canada is erring on the side of caution when it comes to the national flu pandemic preparedness plan. There is preparation for up to 138,000 people in need for hospitalization and between 11,000 and 58,000 death could occur. The economic impact is estimated between $ 10 and 24 billion.
It is true that public health agencies are worried, as three conditions for a possible pandemic are present: the viral strain is a new one, humans have no immunity to this new virus, and the strain is virulent.
The fourth condition would be that the strain could be spread from person to person. However this condition has not developed at this point.
A lot of hype has gone through the press, misinformation is rampant, and as a result people are mixing up influenza preparedness with an avian flu pandemic. Anxiety runs high in the population. Some health professionals are already suffering from pandemic burnout before the virus has even landed, which is not a surprise: in the last few years warnings were sounded due to the outbreak of SARS. West Nile, Ebola, and Lassa fever have been other diseases that caused concern and anxiety. Before jumping to frightening conclusions that the avian flu will jump from person to person, it is important to see the facts in perspective. H5N1 at this point is not spread from person to person. The virus is transmitted from affected birds (chicken ducks, and other fowl) to humans, who have to be in close contact with the animal. The virus is found deep in the lungs of the infected person, and as a result it is more difficult to transmit than a virus that is found in mouth, nose or throat.
Human fatalities have occurred in Asia and the Middle East. Vietnam has had the highest number of deaths related to H5N1: 93 infections, 42 fatalities. Turkey has had 12 documented cases, four of them fatal.
In the meantime the world is not defenseless. Vaccines are in preparation, and vaccination trials are have been introduced in Vietnam. Work with horse antibodies is ongoing and the results are encouraging. Researchers in China developed a passive immunization by using horse antibodies. The advantage is the fact, that larger amounts of vaccine can be produced faster than with the culturing of the virus on eggs.

Avian Flu Needs Preparedness Instead Of Panic

Avian Flu Needs Preparedness Instead Of Panic

Public health agencies and health professionals are aware of the fact that pandemics have been around in the past. They are still a threat now. They agree that programs have to be in place to help mitigate the impact by doing the best they can. Disaster preparedness and alertness are definitely in order. Panic is not.

More information about other flus:

1. the Flu (influenza, H3N2): http://nethealthbook.com/infectious-disease/respiratory-infections/flu/

2. Swine flu (H1N1): http://nethealthbook.com/infectious-disease/respiratory-infections/swine-flu/

3. Bird Flu (H5N1): https://www.askdrray.com/worldwide-alert-for-avian-influenza-bird-flu/

Reference: National Review Of Medicine, March 30, 2006, page 5.

Last edited Oct. 31, 2014

Mar
01
2006

Cystic Fibrosis Patients Benefit From Inhalation

By | Lung Disease

Inhaling has been a humble home remedy for patients who were suffering of cough or nasal congestion and it has not made big headlines in medical treatments.
Scientists from the University of Carolina and the University of Sidney have found, that there is more to old remedies than what meets the eye. In a collaborative study the researchers looked at 188 patients with cystic fibrosis (=CF) for a period of a year. The patients were given saltwater by aerosol to inhale. It turned out that this treatment keeps lung damage at bay. It appears to restore the very thin five to 10 micron layer of water that is missing from the lungs of CF patients, and it facilitates clearance of mucus . All it takes is a little water and ordinary NaCl (table salt). Patients must inhale this inexpensive saltwater solution for 10 to 15 minutes twice daily.

This treatment does not constitute a cure of CF, but it s definitely enhancing the treatment and control of this disease.

Cystic Fibrosis Patients Benefit From Inhalation

Cystic Fibrosis Patients Benefit From Inhalation

For more info on treatment of CF: Treatment of cystic fibrosis

Reference: National Review Of Medicine, January 30,2006, page 5

Last edited October 30, 2014

Jun
01
2005

Smoking During Pregnancy Linked To Adult Asthma

By | Asthma, Lung Disease, obstetrics, Prevention, Women’s Diseases

Smoking during pregnancy has been found to be harmful to the unborn child, and secondary smoke has long been recognized as a health risk for children. Doctors and health care providers keep on pointing out the hazards: aside the risk for the mother-to-be there are the consequences for the children: low baby birth weights, respiratory problems for children.
In the meantime there is another good reason for the pregnant woman (and other household members) to quit. Passive smoking for the unborn child and in childhood seems to have a lasting effect on the airways. There is an increased risk for adult respiratory problems and asthma, reports Dr.Trude Duelien-Skoge, who is a respiratory physician at the University of Bergen, Norway. A long-term study was concluded between 1985 and 1996 involving 2,819 adults. Those participants, who had been exposed to tobacco smoke as unborn babies, were three times more likely to develop adult asthma than individuals whose mothers were non-smokers. Exposure to tobacco smoke in childhood alone was associated with a two-fold risk for adult asthma.

The worst consequences were born by the group that was exposed to tobacco smoke as unborn children and during childhood: they were three-and-a-half times more likely to develop asthma as adults. Several studies pointed to the fact that there are structural changes in the airways of children who had prenatal exposure to tobacco smoke. This does not come as a surprise, as many toxic chemicals from cigarette smoke pass freely across the placenta, and prenatal smoke exposure has been associated with a host of childhood illnesses. From early changes the road is paved to either slow progression of disease or inducing vulnerability in the airways, which only becomes evident with later exposures.

Smoking During Pregnancy Linked To Adult Asthma

Smoking During Pregnancy Linked To Adult Asthma

Due to the far-reaching health risk it is all the more important to be aware of prevention: neither should the unborn child be exposed to cigarette smoke, nor should the growing child be subjected to it, and all efforts should be made to convince the adult smoker of the benefits of quitting smoking.

More information on:

Asthma: http://nethealthbook.com/lung-disease/asthma-introduction/

High risk pregnancies: http://nethealthbook.com/womens-health-gynecology-and-obstetrics/pregnancy-labor-delivery-2/high-risk-pregnancies/
Reference: The Medical Post, May 3, 2005, page 25

Last edited October 28, 2014

May
01
2005

Bird Flu Can Affect Humans

By | Infectious Disease, Lung Disease

Avian Influenza has received significant attention in the media: some articles label it as the new threat in influenza viruses, while others dismiss it as ” only a flu that will infect birds.” Outbreaks have been reported mainly from Asia, but the nasty virus has made it into poultry farms in North America. There is concern that avian influenza could be transmitted from uncooked birds or bird products onto humans. Avian influenza A has indeed been detected in imported frozen duck meat and infected poultry eggs.
Of particular concern is the virus strain H5N2, as it has the propensity to mutate rapidly. At this point the risk of human-to-human, and transmission remains low, but acquiring the infection from sick birds is a reality. The course tends to be more severe in people older than 12 years, while the disease in children tended to be milder and self-limiting. The symptoms in the adult age group presented as follows:
-Fever (100% of the affected patients)
-Upper respiratory tract infections (67%)
-Pneumonia (58%)
-Gastrointestinal symptoms (50%)
Abnormal laboratory test results were:
-Elevated serum aminotransferases (50%)
-Pancytopenia and bone marrow hemophagocytosis (16%)
Guidelines from the Center for Disease Control suggest that travelers to countries experiencing outbreaks of avian flu should avoid areas with live poultry (live animal markets or poultry farms).

Bird Flu Can Affect Humans

Bird Flu Can Affect Humans

Hand hygiene in the form of soap and water or alcohol-base hand sanitizers is important. All poultry products should be cooked, as heat is effective in killing viruses. It is also important to inform the health care provider about flu-like symptoms associated with recent travel; so avian influenza can be considered.
The current influenza vaccines have no protective value against the avian flu. Studies suggest that anti-viral prescription medication may work. As the viruses are becoming resistant to current medications, they are expected to have limitations in successful treatment.

More info about the Flu: http://nethealthbook.com/infectious-disease/respiratory-infections/flu/

Reference: The Canadian Journal of CME, April 2005, page 49

Look for more info about the bird flu at the CDC site of the US

Last edited October 28, 2014

Feb
01
2005

News About The Flu

By | Infectious Disease, Lung Disease, Prevention

Every couple of years new influenza strains seem to develop in Asia and spread thru the rest of the world. When summer comes, the flu season is forgotten and the cycle repeats itself in fall and winter.

Recently there were local outbreaks of two avian influenza strains that according to the name should only affect birds (the “asian bird flu”). Based on research from these two bird flu experiences there seems to be a new way of looking at the development of human influenzas. It appears that new strains of human influenza are born in the bird population of Asia where the virus mutates into new strains. From there it spreads into human care takers (bird-to-human spread) and their contacts. Eventually the virus adapts to the human host and effective human-to-human transmission is incorporated into the DNA of the virus. Now the time is ready for a flu epidemic. It is not clear yet how long this human-to-human transmission switch takes (how many months or years). Here are more details regarding the recent two local outbreaks of asian bird flus:

1. Recently Dr. Arnold Bosman published a study in Holland. He was the health officer in charge of investigating an outbreak of influenza A, type H7N7, affecting a number of chicken farms in Holland between March and May 2003. This was the time of the SARS epidemic that caught all of the media attention at that time. About 86 poultry workers had been infected with flu like illness that caused a viral conjunctivitis of the eyes. However, one veterinarian who was in close contact with the infected birds died from respiratory distress syndrome. Using very sensitive PCR facilitated DNA test they were able to show that these infected people had all the same bird flu with the influenza strain A (type H7N7). When contacts of these people were tested a surprisingly large number, about 1000 with an estimated total of about 2000, people were also positive for antibodies to this particular more harmless strain of bird influenza.

2. The second development is regarding the recent infection of a bird flu in Vietnam that has caused many deaths. This is a much more aggressive influenza A (H5N1), which is the other bird flu that is of concern for the rest of the world. In Vietnam this bird flu type has a mortality of 76%, in other words with this new type of flu 3 out of 4 people die who get it. It all started in December of 2003 and here are the latest details about this flu type.

News About The Flu

News About The Flu

With the new study from Holland the concern among infection specialists is that there likely are a lot more healthy appearing people who become carriers of the disease (like the 2000 contacts in Holland). Experts feel that this type of flu presently might be in the stage of adapting to the human-to-human transmission mode (so far mostly bird-to-human transmission has taken place, which is still a barrier to mass transmission). When the virus has learnt to adapt to human-to-human transmission, there could be a flu pandemic with a new human strain of influenza A (type H5N1) that would rapidly sweep the world.

A Quebec/Canada company (ID Biomedical) is working on an influenza vaccine for the H5N1 virus, in preparation for a possible pandemic. The demand will be so great when a pandemic would happen, that the company is thinking of stockpiling this vaccine so that it would be available when bad news should strike.

In the meantime antiviral antibiotics such as Tamiflu (=oseltamivir) at a dose of 75 mg twice per day for 5 days started within the first two days of the flu aborts the flu effectively according to the experts. Unfortunately this antiviral antibiotic directed against the N1 component of the virus is expensive.

More background information about the flu (medically termed “influenza”): http://nethealthbook.com/infectious-disease/respiratory-infections/flu/

Reference: The Medical Post, Jan. 18, 2005, P. 2 and 56

Last edited October 27, 2014

Dec
01
2004

New Drug Zaps the Avian Flu

By | Infectious Disease, Lung Disease, Prevention

Introduction

Flu shots are considered the most useful precaution to control influenza, but a new drug zaps the avian flu, Tamiflu.  The avian influenza virus threatens commercial chicken flocks. This influenza type has the ability to infect humans as well; it has been a threat in Asian countries. Current influenza vaccinations do not provide immunity against the avian flu. The annual vaccination programs cannot possibly target all of the various types of influenza viruses.

Tamiflu effective against influenza A, B and avian flu viruses

British researchers have found that the neuraminidase inhibitor, which is effective against all subtypes of influenza A and B viruses, is also effective against avian influenza viruses. Senior scientist Shobana Balasingam from Queen Mary School of Medicine in London states that there is no current vaccine available should a pandemic influenza of the avian flu subtype H5N1 emerge.

New Drug Zaps Avian Flu

New Drug Zaps the Avian Flu

Tamiflu works best, if the patient takes it 24 to 48 hours after influenza symptoms start.  In two placebo-controlled, double-blind clinical trials 849 adult patients experienced a reduction of flu symptoms of 1.3 days. They started Tamiflu 40 hours after the beginning of flu symptoms. Patients took 75mg for 5 consecutive days. When another group started Tamiflu 24 hours after the onset of flu symptoms, the treatment outcome improved significantly. However, a higher dose of Tamiflu (150 mg twice per day) did not improve the treatment.

Prevention of influenza with Tamiflu

A clinical trial with 1559 non immunized adults showed an overall protection rate of 74% for all groups. There were some locations in Virginia where the infection rate was higher than in the rest of the US. Tamiflu achieved a protection rate of 82%. In cases where no vaccine is available against a new flu type, Tamiflu is a good alternative to protect the population against a new epidemic.

Reference

The Medical Post, November 23, 2004, page 14

Nov
01
2004

New Remedy Zaps Colds

By | Infectious Disease, Lung Disease, Prevention

A new cold remedy has been developed in Alberta, and researchers from the University of Alberta in Calgary have concluded, that it is definitely doing the job.
Cold-FX is made of North American ginseng, and it cuts the chances of getting an upper respiratory tract infection (like coughs and sniffles) by 26 %. It cuts the chance of getting sick by 56 %. During a study, which has been released on October 5, 2004, 323 adults were tested. Researchers could also demonstrate that the disease fighting white blood cells and lymph cells increased in patients who took Cold-FX.

This study was a randomized study and was quite elaborate in its design. Symptoms of colds were assessed with a scoring system and quatitated. Here is a link to the results published in the Canadian Medical Association Journal (CMAJ October 25, 2005 vol. 173 no. 9 doi: 10.1503/cmaj.1041470).
This study comes in time for winter, which thanks to the new developments does not have to be the season to be sneezing…

Reference: National Review of Medicine, October 15, 2004, page 7

New Remedy Zaps Colds

New Remedy Zaps Colds

Last edited December 7, 2012

Aug
01
2004

Electronic Nose Smells Sickness

By | Health, Lung Disease, Prevention

Sniffing out disease has become a reality with a new device called Cyranose 320.
This electronic “nose” is able to recognize bacteria by sampling a patient’s breath.
The device has been tested and found to be quite accurate, as it was able to successfully diagnose 92 % of pneumonia cases in 25 patients.

This hand-held little invention costs about $8,000, and has been fitted by researchers at the University of Pennsylvania with a smart chip, which is capable of learning chemical “smellprints” of different bacteria. A further study showed that the Cyranose was also able to diagnose sinusitis- the most common respiratory complaint in US outpatient clinics.
This electronic nose will show its value for early detection of pneumonia in the intensive care unit, where patients on ventilators can be safely and quickly tested. About 25 % of these patients on the average develop pneumonia, and the lead researcher of the first study, Dr. William Hanson III, emphasizes that early recognition of pneumonia and avoiding wrong diagnoses is crucial for the swift treatment of pneumonia, which can be life saving.

Electronic Nose Smells Sickness

Electronic Nose Smells Sickness

Reference: National Review of Medicine (Canada), June 30, 2004, page 5

Last edited December 8, 2012