Jul
01
2008

Buprenorphine Prevents Relapses For Heroin Addicts

By | Prevention, Substance abuse

It is a great challenge for persons who are suffering of drug addiction to quit. There is the difficult period of detoxification. Even though there is a lot of support, there will be intense withdrawal symptoms, and every drug free day is a hard won victory. It is a major milestone on the road to recovery to be discharged from a detox program, but the task to remain drug free and abstinent is anything but easy. For this reason it is of utmost importance that support to prevent a relapse is available in the form of counseling, support groups and a maintenance program which involves medication is accessible to the patient.

A standard treatment drug has been naltrexone which helped the recovering addict to remain abstinent. It has been largely used in patients who were recovering from heroin addiction. Dr. Richard Schottenfield from Yale University School of Medicine, New Haven, Ct. and colleagues led a randomized trial to compare the efficacy of the standard drug regimen of naltrexone with the medication Buprenorphine in patients who were in the process of receiving detoxification and drug counseling. A group of patients received placebo (sugar pills that contain no medication.) From the 126 detoxified heroin dependent patients 43 received the standard treatment of naltrexone, 44 received Buprenorphine and 39 took placebo pills.

Buprenorphine Prevents Relapses For Heroin Addicts

Buprenorphine Prevents Relapses For Heroin Addicts

The researchers found that patients who received Buprenorphine lasted nearly twice as long till they experienced a relapse than those who were on naltrexone and more than twice as long as compared to those who took placebo pills.HIV risk reduction behaviors were significantly reduced in all three groups. Maintenance treatment with Buprenorphine is a significant public health approach to reduce problems that are connected with heroin dependence and can make a difference to the recovering heroin addict on the path of abstinence from the drug.

More information about opium and heroin addiction: http://nethealthbook.com/drug-addiction/opium-heroin/

Reference: Lancet (2008) vol.371, pages 2192-2200 and 2150-2151

Last edited November 4, 2014

Jun
01
2008

Diabetes Onset Can be Delayed

By | Diabetes, Fitness, Nutrition, Prevention

Diabetes delayed by diet and exercise

Prevention is the buzzword in healthcare, but often medicine has to embark on the curative avenues. With the onset of a health problem patients are often tempted to throw in the towel: it’s too late now anyways. There is nothing I can do. It’s up to medication, pills or shots to get a handle on my problem. Nothing could be further from the truth, as major clinical trials have shown, when it comes to intervention to prevent the onset of diabetes. There is a stage where lab tests show that a patient has impaired glucose tolerance. He or she is”pre-diabetic”. Without intervention the development of diabetes is more or less imminent. But this does not mean that “it is too late “. It is exactly at that point, where lifestyle intervention can make a difference. How long do these post-intervention studies remain effective? Professor Guangwei Li at the China-Japan Friendship Hospital in Beijing, China and Dr. Ping Zhang from Centers for Disease Control and Prevention followed up patients 20 years after enrolment. In 1986, 577 adults from 33 clinics in China were randomly assigned to a control group or one of three lifestyle intervention groups (diet, exercise or diet and exercise combined).

Diabetes Onset Can be Delayed

Diabetes Onset Can be Delayed

All of the patients had impaired glucose tolerance. There was an active intervention program until 1992, and in 2006 participants were assessed for the long-term effect of the interventions. The results showed that the combined lifestyle interventions reduced the incidence of diabetes by about half during the active intervention period of 6 years. Over the 20 year duration the reduction was 43 %. At the end of the 20 year period 80% of the intervention group had developed diabetes, whereas 93% of the control group that had not followed a lifestyle intervention program were diabetic. The researchers reported that lifestyle intervention programs for patients with impaired glucose tolerance can indeed make a difference. A six year intervention program can delay the onset of diabetes by 14 years.

More information about diabetes: http://nethealthbook.com/hormones/diabetes/

Reference: Lancet 2008;371:1783-1789; 1731-1733.

Last edited November 3, 2014

Jun
01
2008

Boost Babies’ Health with Mom’s Diet

By | Allergies, Asthma, Health, Nutrition, obstetrics, Prevention, Vitamins and supplements

Prenatal supplements and good advice on proper nutrition during pregnancy have long been included in proper prenatal care. Importance has been placed on folic acid to prevent neural tube defects in the fetal development. Calcium is recommended, often in the form of dairy products, but it does not end there: just swallowing the supplement and adding some more milk may be helpful but not quite enough. Certain dietary habits have been found more beneficial, such as the eating habits in the Mediterranean countries. A research team from the University of Crete in Heraclion, Greece included women who were involved in antenatal care at all general practices in Menorca, Spain. The study took place in the time frame of 12 month starting in 1997. After six and a half years 460 children were also included in the analysis.

Dietary habits were studied and assessed by food questionnaires and the children were assessed for the development of allergies and asthma.

Boost Babies’ Health with Mom’s Diet

Boost Babies’ Health with Mom’s Diet

The children of mothers who consumed the most vegetables, fish and legumes were almost 80% less likely to have persistent wheeze and more than 40 % less likely to have allergies. The results are consistent with the fact that a high level of adherence to the Mediterranean diet during pregnancy is protective not only to the mother but also to the child.

More information about prenatal visits (where nutritional habits are checked as well): http://nethealthbook.com/womens-health-gynecology-and-obstetrics/pregnancy-labor-delivery-2/prenatal-visits/

Reference: The Medical Post, April 22, 2008, page 25

Last edited December 18, 2014

Apr
01
2008

High Blood Pressure Decreases Cognitive Function

By | Heart Disease, High Blood Pressure, Prevention, Stroke

It is known that high blood pressure that is left untreated gives rise to a host of health problems, some of which are heart attacks and strokes. It is not surprising to Dr. Jose Luchsinger of Columbia University Medical Center in New York that high blood pressure (hypertension) can be related to all kinds of cognitive impairment, which is connected to vascular damage in the brain. A cohort study which was published in the December issue of Archives of Neurology included 918 subjects age 65 or older with no history of mild cognitive impairment (MCI) or dementia at baseline. All participants underwent neurophysical and medical testing every 1 ½ years for more than 4 ½ years. The majority of the individuals had high blood pressure. During the course of the study 334 of the participants developed MCI. 174 cases had impairment in domains such as language and executive function or visual-spatial elements were impaired. 160 individuals had amnestic MCI (affecting memory), which is thought to have the strongest link to Alzheimer’s disease.

High Blood Pressure Decreases Cognitive Function

High Blood Pressure Decreases Cognitive Function

The study showed that hypertension played a significant role in the higher risk of developing any form of cognitive impairment. Detection of hypertension and proper treatment will not only protect against strokes, but certainly also extend its benefits to cognitive function.

More information how strict blood pressure control prevents trouble: http://nethealthbook.com/news/stroke-risk-present-even-borderline-high-blood-pressure/

Reference: The Medical Post, February 5, 2008, page 65 and Dec.2007 issue of Archives of Neurology

Last edited November 3, 2014

Sep
01
2007

MS Vaccine Breakthrough

By | Multiple sclerosis, Prevention

One of the great hopes associated with genetic research is the goal to combat disease. With the human genome project completed it is now possible to look at new therapies. The work remains large and seems to be overwhelming, but a new vaccine for MS represents a major triumph. MS has been an illness that has devastated individuals and their families. It also has vexed and frustrated researchers and health professionals. Immunomodulating therapy with interferon has been able to make a difference in the quality of life for many patients, but so far it has been a seemingly impossible dream to find a vaccine that is safe and effective.

Montreal research, which has been published in August, confirms that the vaccine works by reducing the numbers of the immune system cells attacking the nerve fiber sheath. MS belongs to the groups of autoimmune diseases, meaning that cells of the own immune system turn against other body cells and destroy them. The challenge has been to stop these cells. So far immunomodulators have been looked at as an answer to this problem. This breakthrough represents a first in the history of medicine where a DNA vaccine will be used in the treatment of an autoimmune disease, which is MS.

MS Vaccine Breakthrough

MS Vaccine Breakthrough

Other autoimmune diseases are lupus or rheumatoid arthritis. No vaccine is available for these diseases, but the first DNA vaccine represents hope for many, that more therapies will become available.

As this review shows, the DNA vaccine experiment against MS failed, because in clinical trials it did not stop MS lesions from growing: http://multiple-sclerosis-research.blogspot.com/2012/01/research-myelin-dna-vaccination-and.html

More information about MS: http://nethealthbook.com/neurology-neurological-disease/multiple-sclerosis/

Reference: National Review of Medicine, August 30, 2007, page 10

Last edited November 3, 2014

Sep
01
2007

Ginseng Lowers Risk For Common Cold

By | Infectious Disease, Lung Disease, Nutrition, Prevention, Vitamins and supplements

In Chinese medicine the ginseng plant has been widely used. Its history in North America seems to be shorter at first glance, as it received more attention only, as Chinese medicine and acupuncture have become popular over the last decades. The Asian variety of ginseng known under its botanical name as Panax ginseng is only one of the species. There is however a variety which is native to the eastern part of the North American continent with the botanical name Panax quinquefolius. The first people using it were various Native American groups. They found it useful for childbirth and fertility. It was also used to help those with shortness of breath.

Ginseng root was considered the more valuable part of the plant, and new research has found that root extracts of the North American ginseng have an influence on the immune system. The substance enhances the production of interleukin and interferon-gamma. The immunomodulary effects which can help in the prevention of respiratory disease have also been studied in clinical trials involving older adults.

It turned out that the likelihood of developing acute respiratory illness was significantly lower in the group that was treated with a standardized formulation of 200 mg ginseng extract twice a day than in a group that did receive placebo or no treatment. It was also observed that the number of patient who had common colds was reduced in those who received ginseng. The absolute risk reduction of recurring common colds was 12.8 % and the total number of days with cold symptoms was 34.5% lower in the treatment group.

Ginseng Lowers Risk For Common Cold

Ginseng Lowers Risk For Common Cold

Long term studies are still outstanding, but based on the interim findings ginseng extract taken in the winter month can be beneficial especially in the older population as a weapon against respiratory illness.

More information on:

1. Preventing the flu: https://www.askdrray.com/fighting-back-against-the-flu/

2. General info on ginseng: https://www.askdrray.com/studies-show-ginseng-works/

Reference: J. Altern. Complement. Med. 2006;12:153-7.

Last edited November 3, 2014

Sep
01
2007

Emotional Distress Impairs Cognitive Function

By | Heart Disease, Mental Health, Prevention, Stress management

Stress has been linked to numerous medical conditions, such as heart disease, stomach problems and muscle spasm. Stress also has been quoted as a silent killer.

Research in the field of Alzheimer’s has shown that negative emotions and chronic distress are associated with increased vulnerability to this disease.

Study author Dr. Robert Wilson of the Rush’s Alzheimer’s disease Center in Chicago has found that people most prone to psychological distress were 40% more likely to develop mild cognitive impairment (MCI) than the group that is least distress prone.

Dr. Wilson stated that these individuals would not necessarily see a psychiatrist to help them deal with their negative emotions. It becomes clear, however, that persistent negative emotional states truly impact the physical well being, and also the cognitive status. For this reason more medical attention should be given to an older patient with emotional problems and even mild depression.

Emotional Distress Impairs Cognitive Function

Emotional Distress Impairs Cognitive Function

It can become a treatment challenge, if there are personality traits or deeply entrenched behavior patterns that may not respond well to treatment. By understanding the biological link between chronic distress and loss of cognitive function in old age, early intervention can be a way to delay symptoms or to prevent disease onset.

More information on Alzheimer’s: http://nethealthbook.com/neurology-neurological-disease/alzheimers-dementia-and-delirium/

Reference: The Medical Post, August 7, 2007, page 53

Last edited November 3, 2014

Sep
01
2007

Gene Identification Helps To Screen for Diabetes Risk Of Juvenile Diabetes (type 1 diabetes)

By | Diabetes, Hormones, Prevention

Gene therapy is the new buzzword in a hope for cure of disease, and genetic tests also assist in predicting the risk for disease.

These predictions are reaffirmed by research that comes from McGill University in Montreal under Dr. Constantin Polychronakos, a professor of pediatrics and human genetics. A new DNA chip has been used for testing the genetic makeup that produces diabetes type 1 (also called Juvenile Diabetes). So far the analysis has confirmed four previously identified genetic locations that contribute to the development of diabetes 1, and the test identified a new location occupied by the gene.

With the research team working on the discovery of all the remaining genes, they are confident to develop a test which will predict the risk of developing diabetes. According to Dr. Polychronakos the findings will influence future treatment options. The most promising treatment for those already diagnosed with diabetes1 are stem cell regenerative treatments, such as islet transplantation, since the Langerhans islets are responsible for the production of insulin in the pancreas.

Gene Identification Helps To Screen for Diabetes Risk Of Juvenile Diabetes (type 1 diabetes)

Family tree for inheritance of type 1 diabetes

These therapies will only work if the immune system is also treated, so the patient does not suffer a relapse of the disease. Once all the diabetes genes are identified, there will not only be fast screening but also therapies that can be targeted more effectively.

Reference: The Medical Post, August 7, 2007, page 1 and 60 of the Medical Post

More on genetics and diabertes: http://www.who.int/genomics/about/Diabetis-fin.pdf

Last edited December 5, 2012

Aug
01
2007

Alcohol Can Be Culprit in Irregular Heart Beat

By | Heart Disease, High Blood Pressure, Prevention, Substance abuse

Dr. Gregory M. Marcus, an electrophysiologist at the University of California, San Francisco gave a presentation at the Annual Meeting of the Heart Rhythm Society about the effect of alcohol on the heart in younger people.   This convention took place at the Colorado Convention Center at Denver/Co. where from May 9 to 12, 2007 about 11,000 physicians and scientists gathered to discuss the newest in irregular heartbeats (arrhythmias) and new treatments. Dr. Marcus found that in persons younger than 60 years of age one alcoholic drink per day could lead to atrial fibrillation (=atrial fib) or to atrial flutter. He found in persons older than 60 years he was not able to show a statistically significant risk effect of alcohol, but he pointed out that in this older population there were other risks like older age by itself and hypertension, both of which were independent risk factors for atrial fib/atrial flutter.

This was a case study where 195 consecutive patients with atrial fib/atrial flutter were studied. 2/3 of them were 60 or younger. There were also 185 controls with 75% who had supraventricular arrhythmias and 25% with healthy hearts.  There was a linear dose-response curve between number of alcoholic drinks consumed per day and atrial flutter. With atrial fibrillation there was a tendency in this way, but it had not reached quite statistical significance.  This study is the first one to show that in the younger age group there is sensitivity, at least in those who came down with atrial fib or atrial flutter, of the conductive nerve fibers in the atrial wall tissue to the effects of alcohol. Alcohol seems to reduce the effective refractory period of atrial tissue. Dr. Marcus called this the arrhythmogenic effect of alcohol.

Alcohol Can Be Culprit in Irregular Heart Beat

One drink a day can cause atrial fibrillation

It is not clear at the present time how to balance the cardioprotective effect of moderate alcohol intake against this newly found arrhythmogenic effect.  Also, why would the younger age group be more vulnerable to this effect than the older generation? Is there perhaps a subpopulation of more sensitive patients? These are unanswered questions, but at any rate it is important that those who had atrial fibrillation or atrial flutter refrain from alcohol, as they have shown to be especially sensitive to this arrhythmogenic effect.

More information about irregular heart beats: http://nethealthbook.com/cardiovascular-disease/heart-disease/irregular-heart-beats/

Reference: Dr. Gregory M. Marcus at the Annual Meeting of the Heart Rhythm Society

Last edited November 3, 2014

Aug
01
2007

Nicotine Addiction Found More Often in Impulsive Behavior

By | Heart Disease, Lung Disease, Mental Health, Prevention, Substance abuse

Why do major depression and nicotine addiction often occur together in middle aged people? This is what Dr. Qiang John Fu, assistant professor of community health in biostatistics at Saint Louis University School of Public Health, asked himself and he conducted a study involving 3,360 pairs of middle-aged, predominantly Caucasian twins to find out. Twin studies are a powerful tool to sort out environmental factors from genetic factors. In this particular study the twins had served in the Vietnam war and 45% were fraternal, the rest were identical twins. With identical twins 100% of the genes are identical while the fraternal twins share about half of the genes.

The researchers found that a group of twins who were addicted to nicotine also had a behavioral disorder, called conduct disorder. This can be well defined with psychological tests and is characterized by behaviors such a stealing, fighting, vandalizing, running away from home and drug addiction (including addiction to nicotine). They were also the ones who were much more vulnerable to develop major depression.  As published in the June issue of Twin Research and Human Genetics Dr. Fu, MD, PhD, the lead researcher explained that he found a set of genes that are responsible for the development of major depression and for addiction to nicotine.

Nicotine Addiction Found More Often in Impulsive Behavior

Major depression and nicotine addiction are linked through a gene

These individuals attempt to self-treat depression with cigarette smoking. Linked with this can also be the conduct disorder mentioned above.  These findings may lead to newer approaches in terms of treatment.

Reference: June issue 2007 of Twin Research and Human Genetics

Last edited December 5, 2012