Prevention Archives

May

2013

Changes Of Gut Bacteria Can Cause Heart Attacks

By Ray Schilling | Cancer, Health, heart attack, Heart Disease, Prevention, Stroke, Vitamins and supplements

The recent news of gut bacteria possibly being involved in causing heart attacks (see details below) sounds pretty outrageous. In order to make this more understandable, we need to start backtracking how bacteria end up in our gut and what they are doing there.

Gut bacteria in our bowels at various stages in life

Even among infants there is a huge difference in the composition of the gut flora depending on whether the baby was vaginally delivered, born by Cesarean section or prematurely born and nursed in an intensive care unit for a prolonged period of time.

When we are grown up, it depends on where we live on our planet as to what type of gut flora we have. A 2011 study of the bacterial composition of stool samples in Europe versus Africa showed that the European microbiome in the colon was typical of the Bacteroides enterotype, whereas the African microbiome was dominated by the Prevotella enterotype. Other studies have shown that the type of diet we eat causes us to harbor different types of gut flora. A person eating a more vegetarian diet will have a Prevotella enterotype gut flora, while another person eating a Western style fat and protein dominated diet will have a Bacteroides enterotype gut flora. What is the gut flora doing? It lives within our gut for our mutual benefit. We provide the gut bacteria a comfortable home at body temperature where they grow best. They in turn ferment undigested foods, protect us from the growth of harmful bacteria, produce vitamins like vitamin K and biotin, and produce hormones that direct the body to store excess food as fat.

Changes Of Gut Bacteria Can Cause Heart Attacks

Cleveland Clinic’s gut flora research linked to heart attacks

In April 2013 reports that heart attacks may be related to the composition of your gut flora hit the popular press, articles like this. Two years earlier, in April of 2011, the same Cleveland research group under Dr. Stanley Hazen found that the gut flora composition has an impact on heart disease. They stated that a “byproduct called trimethylamine N-oxide (TMAO) is produced when intestinal bacteria digest the nutrient phosphatidylcholine, commonly known as lecithin”. It was determined that the liver was responsible for producing TMAO out of absorbed materials from gut bacteria and that this was responsible for accelerating hardening of the arteries, which in turn caused deadly heart attacks and strokes.

As can be seen from this link the Cleveland research group is suggesting that TMAO could become a valuable screening tool when measured in patients’ blood to screen for their risk to develop a heart attack or stroke in the future. Furthermore, once these patients are identified, they can be sent to a dietitian and be put on a different diet that prevents heart attacks and strokes; also, the progress could again be monitored through repeat TMAO blood tests down the road.

Criticism of research from the Cleveland Clinic

Not every one has welcomed the study as clear-cut proof for a link between the gut flora and heart attacks, strokes and deaths. This link shows that it is questioned whether perhaps low antibiotic residues in red meat would explain the findings of the study. It rightly points out that there was no control for whether the more than 4000 patients were eating organic foods or a regular American diet. The comment goes on to say that the regular American diet contains residual antibiotics from milk, milk products, beef, chicken and turkey. These traces of antibiotics are powerful enough to have an effect on the gut flora, which likely is the reason for the differences between the vegetarian diet versus a Western style fat and protein dominated diet. It is entirely possible that grass fed beef would not lead to TMAO levels in the blood whereas regular beef or hamburger meat will raise the TMAO levels. The same could be true for egg consumption, which was also accused of raising TMAO levels. However, we do not know whether organic eggs that do not contain antibiotics would have done the same as regular eggs that contain traces of antibiotics.

Cancer caused by gut flora

This 2008 review article explains how lactobacillus and bifidobacteria (probiotics) prevent colon cancer, while bacteria of the Bacteroides and Clostridium variety increase the incidence of colon cancer and the growth rate of colonic tumors. So, the composition of your gut flora does not only matter with regard to prevention of heart attacks and strokes, but is also important in preventing colon cancer.

Change your gut flora to boost your health

Here is where the “rubber hits the road”. What I mean is that you can benefit from all of this research with regard to your health by paying attention to a few facts and possibly making a few changes as follows.

I think that the argument of the bulletproofexec.com website holds true and we should all eat organic meats whenever possible. The Cleveland study has already shown that the gut flora in vegetarians stayed healthy even when they occasionally slipped and ate a regular steak.
Take supplemental probiotics from the health food store. It will improve your gut flora within a day or two.
Higher intake of fruit and vegetables make a measurable difference in the body decreasing the risk for heart attacks and strokes as this British research group has shown. Another research group from Italy has confirmed that an increased intake of fruit and vegetables mobilizes genetic switches that will stabilize the metabolism of the gut wall and prevent cancer of the colon.

So, the verdict for boosting your health is out: eat organic foods, use probiotics as supplements and eat more fruit and vegetables!

More information on nutrition: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/

References

Last edited Nov. 7, 2014

May

2013

Get Rid Of Toxins Safely

By Ray Schilling | Alzheimer’s disease, Anti-aging medicine, Arthritis, Cancer, Diabetes, Health, Heart Disease, kidney disease, Nutrition, Prevention, Stroke, Vitamins and supplements

This article is about “get rid of toxins safely”. You often hear that people use chelation at home with natural foods. Is that true?

The standard chelation detoxification

I like to mention in the beginning that the proven way to reduce heavy metals in the blood (typically mercury and lead) is by intravenous chelating agents such as EDTA. However, the lowering of calcium levels as a severe side effect limits the application of it. There are also blood-thinning side effects to consider. EDTA is a chemically synthesized compound, not a natural substance. Conversely, vitamin C and Glutathione are both antioxidant substances that the body knows; they are non-toxic and can be used more easily intravenously to remove heavy metals like lead and mercury with fewer side effects than EDTA.

Natural ways to use chelation in order to detoxify

Although I think that EDTA has a place in the hands of those who are knowledgeable about the side effects, the vitamin C/Glutathione combination is probably a more physiological detoxification method as glutathione is synthesized by the liver to detoxify our bodies. Intravenous chelation is expensive, requires access to a vein and may not be a suitable way for many people to detoxify. There are natural ways to detox for those who cannot afford chelation or cannot chelate for other health reasons. The major detoxification organs are: the liver, the kidneys, the gut, the lungs and the skin.

What about oral methods to detoxify?

Several methods of cleansing are fasting, the major cleanse or the raw food cleanse. I would not advise to do strict fasting without fluid intake as it takes fluid intake to be able to dissolve any released toxins into urine, feces, invisible fluid from exhaled air and nasal discharge. Next there is the “master cleanse” with lemon juice, maple syrup and cayenne pepper as indicated in the link above. Some people like trendy procedures that they find in a magazine or in a self-help book. I do not like it, as it reminds me too much of a cookbook approach.

A Vitamix is a good tool to create turn your fruit/vegetables into a chelating tool

I feel differently about a raw food cleanse as I will explain. First, I like to point out that raw food is not easily digested as your gut absorbs only about 30 to 40% of the nutrients. The cell walls of the vegetables you use are the barrier towards absorption. This is much different, if you put the raw fruit and vegetables into a blender with a high-power motor. (There are several brands like the BlendTec or the Vitamix.) The powerful blending process breaks up the cell walls and releases the content of the plant cells including their enzymes and nutrients, so that 80% of the nutrients are absorbed in your gut.

Get Rid Of Toxins Safely

If you use organic ingredients (they do not contain toxins, artificial fertilizer residues etc.) you cannot go wrong! Use spinach, kale, banana, mango, greens, lemon juice, and for fat add some nuts like walnuts, Macadamia nuts, almonds (with the proviso that you are not allergic to them). With the help of a powerful blender all this will turn into a liquid drink that actually tastes OK. For protein supplementation I would also add some protein supplement like vegan protein from the health food store, whey protein or egg white protein (good to rotate these protein supplements). This mix is a complete nutritional program as it contains complex carbohydrates from fruit and vegetables, fat from nuts, protein from the protein supplement and fiber (from the whole vegetables and fruit).

Natural detoxification from organic fruit and vegetables

You will not get hunger pangs as with a fast or the master cleanse. Use the signs of your body as guidance. If you feel energized after 5 days, stop then and return to your normal food intake. This is a zone type diet, a Mediterranean diet or South Beach diet as explained below. Some people have the willpower to do 7 to 10 days of the liquid diet described. Good for them, at least they do not starve themselves as the calories and total nutrient content are there while they detoxify. What are the agents that lead to the detoxification process? The enzymes from the fruit and vegetables, the lack of toxins as you only consume organic ingredients, the extra vitamin C from the food and the glutathione from your liver are all working together for detoxification.

Are there supplements that can help you to detoxify?

Chlorella powder, which you can buy in health food stores, is one of the few supplements that can detoxify your body from heavy metals. As Dr. Mercola describes that in Japan chlorella powder is one of the most popular supplements to detoxify. It is difficult to get a complete, non-biased picture about chlorella. I did an extensive research in MD Consult about the scientific evidence for detoxification by chlorella in humans. Unfortunately, the search results came back only for experiments with mice and rats, but there were no human detox results.

Chlorella detoxification

Perhaps the Wikipedia description about the history of algae and chlorella as a possible food supplement sheds some light on the difficulties getting real hard data on chlorella detoxification. Researchers poisoned rats deliberately with cadmium (a heavy toxic metal). There was no evidence of detoxification with chlorella when the researchers stopped cadmium poisoning. However, the article goes on to say that chlorella did prevent absorption of cadmium from the intestines to a certain extent (in rats).

Liver detoxification and colonic detoxification

Dr. Max Gerson invented coffee enemas many years ago when he treated end stage cancer patients with natural methods. He found that when he detoxified them with raw juices, many cancer patients died from the toxic breakdown products of dying tumor cells. So he was in dire need of a procedure that would remove the toxic tumor substances efficiently. This is when Dr. Gerson used coffee enemas. As the link above describes, coffee given through the colon as an enema (we would perhaps call it “coffee colonics” today) stimulates the liver and the bile flow thus detoxifying the blood effectively of toxic materials. In addition, the secretory capability of the large surface of the colon wall also helps the detoxification process. Juicing in combination with coffee enemas improved Dr. Gerson’s end stage cancer cure rates dramatically.

Dr. Kelley introduced supplementation with Mega pancreatic enzymes

Subsequently, Dr. Kelley developed his nutritional-metabolic therapy for end stage cancer patients where he added large amounts of pancreatic enzymes in addition to coffee enemas. Dr. Denis Burkitt is credited for recognizing the importance of fiber in the diet. He noticed that there was a striking difference between the colon cancer rates in England versus the rates in Africa. He analyzed food habits in both locations and found that in England there was not enough fiber consumption.

Diet high in vegetables, fruits and whole grains reduces colon cancer rates

A large study done by the Harvard Medical School showed that it was not so much the fiber that helped to prevent colon cancer. Further large scale studies were done and it was shown that a diet high in vegetables, fruits, and whole grains was what was responsible for a reduction in colon cancer rates. This type of diet will also help detoxify your system from carcinogenic substances in general and from other toxins as the soluble fiber inside the gut will attach to it and go down the toilet instead of being reabsorbed in the colon into your system causing cancer.

Skin detoxification

The skin is the largest body organ with a lot of skin surface where skin pores can help detoxify under the right circumstances. You can achieve this with infrared saunas, with exercise that leads to production of sweat and by soaking in Epsom salt baths. Traditionally this has been done for centuries in the European spas, originally described by Sebastian Kneipp. The medical establishment in Europe (France, England, Germany, Austria), unlike American physicians, embraced the concept of natural therapies under the term “balneology”, at least for a number of decades. But overuse by patients (abusing the system), badmouthing the relatively weak effect of detoxifying by Big Pharma and lack of funds from the health insurance companies put a damper on his movement. Part of this approach was the use of skin detoxification with healing baths (using Epsom salt and other salts) and physical exercise to the point of sweating.

Wechselbäder according to Sebastian Kneipp

In addition, “Wechselbäder” according to Sebastian Kneipp (alternating hot and cold baths) are also useful to stimulate the circulation and the immune system. The major component of Epsom salt is magnesium sulfate, which can be absorbed through the skin to a certain degree. So, some of the healing effect of Epsom salt baths may have come from an indirect balancing of low blood magnesium and the normalization of many metabolic processes that require magnesium as cofactors. Here is another, more vernacular description of Epsom salt use. Some of the assumptions such as improvement of diabetes, improvement of digestive absorption or relief from migraine headaches may be a combination of exaggeration and placebo effect rather than reality.

Kidney detoxification

The kidneys along with the liver are the major, natural detoxification organs of the body. However, they need enough fluids to dissolve water-soluble toxins and eliminate them from the body through the urine. Consume clean water intermittently during the day (reverse osmosis water in glass bottles or BPA free bottled water). Because alcohol is a cell poison damaging the vital organs like the brain, heart, liver and kidneys it is best to minimize any alcohol intake to the absolute minimum (best to avoid alcohol altogether). The main filtration devices in the kidneys are the glomeruli, little packages of convoluted capillaries, which filter the blood several times per day.

Too much salt and sugar interfere with normal glomerulus function

High salt intake, too much sugar and too much starch interfere with normal function of the glomeruli. Insulin resistance in cases of metabolic syndrome and diabetes (often in people with obesity) can damage the kidneys. In this case the filtration devices of the kidneys suffer damage and cause toxin accumulation. To prevent damage of the kidney capillaries you need a healthy, basic diet like the Zone diet, South Beach diet or the Mediterranean diet as mentioned in this link.

This will keep fat deposits out of your arteries and maintain the capillaries of the glomeruli of your kidneys. This means that the filtration process continues to work until a ripe old age. Your doctor can order tests (creatinine clearance) to assess whether the filtration capacity of your kidneys is normal.

Many toxins are fat-soluble

Many toxins are fat-soluble and store in the fatty tissues. When you lose weight, you need to drink more fluids to get rid of the water-soluble toxins. This occurs through the kidneys. You can also use coffee enemas to rid yourself of fat-soluble toxins (through bile and bowel movements).

There are a lot of websites that want to sell you herbs that should cleanse your system. They have a marginal effect. But I like to stress that you want to adopt one of the diets mentioned above first. This starts you with a healthy baseline. Such herbs as Buchu (Agathosma Betulina), Burdock, Echinacea and Yellow Dock Root (Rumex Crispus) are supposed to help the kidneys to detoxify. I am not certain whether there is medical proof for this.

Conclusion

Detoxification starts with adopting healthy food and lifestyle habits first. A low carb, low fat type diet (zone diet, a Mediterranean diet or South Beach diet) are essential. They are the footing from which the other detoxification methods work. Some of the toxins will leave you when you work out and sweat. More will leave you when you enjoy an Epsom salt bath. This gives you some extra magnesium, which in turn detoxifies your system. The detoxification takes place through several biochemical reactions where magnesium is a cofactor. Colonics or enemas will help remove toxins through your colon and they are more effective when coffee enemas are used (stimulation of your liver through the splanchnic nerves).

Infrared saunas

Infrared saunas can help to mobilize toxins and detoxify them through your skin. Take ample amounts of fluids as this will help remove some toxins through the kidneys and the urinary system. If the physician detects major heavy metal poisoning, the traditional intravenous chelation treatments are more recommendable. A naturopathic physician or A4M physician (anti-aging physician) could advise you what is best in your case. Overall the thought is that by removing toxins the mitochondria in our cells will work more efficiently. They are particularly concentrated in the brain, heart, liver, and kidneys. When they work more effectively they give you more energy and prevent major diseases. These diseases are cancer, cardiovascular disease (heart attacks and strokes), diabetes, arthritis and loss of cognitive function. The latter prevents Alzheimer’s disease and dementia.

More information about:

1. Chelation therapy: https://www.askdrray.com/tact-study-proves-effectiveness-of-chelation/

2. Vitamins, minerals and detoxification: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/vitamins-minerals-supplements/

Apr

2013

April Is Autism Awareness Month

By Ray Schilling | Allergies, Alzheimer’s disease, Autism, obstetrics, Prevention

Notably, it is worth to mention that April is autism awareness month. Recently autism was in the news as the wife of deceased Bob Denver, who was the actor Gilligan from Gilligan’s Island and founder of The Denver Foundation to help children with disabilities, has written a book where their son Colin’s problem with autism is described. Indeed, autism is a relatively new disease entity. Another key point, we are now talking about the autism spectrum disorder.

What autism is

Autism is a certain behavior/symptom constellation expressed with different degrees of severity in children diagnosed with autism. It is important to realize that autism is much more common in males than in females. In the following I will discuss risk factors for autism, then review why it is so important to diagnose autism right away so that treatment for it can be started earlier than in the past. It is good that April is autism awareness month, as more people will watch out for this diagnosis.

Risk Factors For Autism

Autism has been found to be due to a combination of factors.

1. Compared to a few decades ago women are often older than 30 and men frequently older than 40 when they decide to have children. But studies have shown that when a man fathers a child at the age 40 or older the risk of the offspring to develop autism is higher than when the father is younger than 30.

2. A woman above 30 is already getting into the older age category from the viewpoint of reproduction. Her natural progesterone production from her ovaries is declining. Progesterone production is paramount for keeping a pregnancy alive in the first 10 to 12 weeks. Also, the placenta of a pregnant woman above the age of 30 is not producing as much progesterone as a woman in her early or mid 20’s. However, a high progesterone production of the placenta is necessary to prevent premature labor.

Premature, underweight children

The consequence of this can be that older women give birth to premature, underweight children (Ref. 1 and 2) who are at a higher risk to have neurological problems including autism. Children with a low birth weight have 5-times higher autism rates when compared to children with a normal birth weight. When a woman has gestational diabetes there can be overgrowth of the fetus and like for prematurely born, underweight children there is a definite risk for a baby born much later than the expected date to develop autism.

April Is Autism Awareness Month

Genetic and epigenetic factors triggering autism

3. There are genetic and epigenetic factors that can trigger autism. Shank mutations are responsible for idiopathic autism spectrum disorders (ASD) both in humans and in mice. This confirms an earlier study from 2006 in France where Shank 3 gene mutations were found in human autism cases. Recently research from Stanford University identified another genetic mutation, namely neuroligin-3 amino acid substitution and a neuroligin-3 deletion, which can be responsible for autism in mice.

Epigenetic switches

Epigenetic switches play an important role in the placenta. Research from the University of British Columbia showed this as the key for understanding autism. Another publication also stresses the importance of epigenetic switches. Stress during pregnancy can lead to changes in placental biochemical pathways, which causes prenatal epigenetic programming in the direction of autism. However, it appears that the various research findings are converging to only a few key biological processes. April is autism awareness month; so every April these facts reach the public at large.

4. A lack of serotonin from the placenta may lead to autism in the fetus as this publication shows.

5. Certain toxins such as PCB can disrupt the development of normal neuronal pathways in autism. Even a frequently used anti-epileptic drug, valproate (Depacon), has recently been identified as causing a 5-fold increase in autism during pregnancy.

Low vitamin D levels in pregnancy causes autism

6. In April 2009 a study from the Karolinska Institute investigated a Somalia refugee subpopulation that were found to have high autism rates in Sweden and in the US, due to very low vitamin D levels during the pregnancy. One theory was that one cause for autism was vitamin D deficiency in the mother’s womb. A lack of Vitamin D may be the epigenetic trigger to change metabolic processes. This could cause the subtle metabolic changes that occur in autistic children.

7. In 2007 this study showed that the typical delay of the diagnosis for autism in the US was about 18 months and that the average rate at this point was 1 in 150 live births.

Accelerated brain growth followed by slow brain development

8. Apart from these factors there are other observations that are closely related to the diagnosis of autism. Children with autism show remarkable brain growth during the first year of life. However, subsequently they have a period of slowed brain development (Ref.4). There seems to be an inflammatory process associated with the neuropathological changes in the brain. This results in disconnections and a lack of communicative connections between various parts of the brain. This leads to a lack of higher brain functions like speech and social skills. MRI scans have shown specific changes in some severe cases of autism, but this is not uniform enough between cases to use as a diagnostic tool.

Biomedical approach

The author of Ref. 5 uses a “biomedical approach”, which assumes that autism is a syndrome that is genetically based, but triggered by certain factors as listed above (point 1 to 6 and possibly more) during the time of the pregnancy, in the neonatal period and in early infancy. This leads to the changes in the gut (leaky gut syndrome), in the central nervous system, to food allergies, autoimmune reactions and metabolic changes. According to Ref. 4 biomedical practitioners have remarkable treatment successes by identifying where the problems are and treating each one of them.

Autism spectrum disorder – Diagnose Autism Now

DAN (“diagnose autism now”) physicians who take a special interest in children with autism have shown that an early diagnosis of autism and early intervention with a well-orchestrated treatment protocol can lead to good outcomes, where the child is often losing the diagnosis of autism and developing normally. DAN physicians are changing into the Medical Academy of Pediatric Special Needs (MAPS), but the goal of helping autistic children early is the same. I have described the multi-step treatment protocol under Ref. 2 in the Net Health Book.

Hyperbaric oxygen (HBOT) and detoxification

Briefly, the physician orders a multitude tests initially to establish the diagnosis and the severity of the autism spectrum disorder. This gives the doctor the basis for a personalized treatment approach. A combination of hyperbaric oxygen (HBOT) and detoxification with intravenous chelation treatments removes toxins and heavy metals from the body. Stool samples determine whether Clostridium difficile or Candida albicans is present, which are appropriately treated. Dysbiosis, a term to describe an abnormal gut bacteria mix, is common. The doctor rectified this with probiotics. If leaky gut syndrome is present (in 43% to 76% it was shown to be present in three different well controlled studies, Ref. 4), this may also point to food allergies and autoimmune problems. The physician addresses these as well. Along the line of abnormal gut bacteria in autistic children, new research is considering the development of a vaccine to help normalize gut bacteria.

A metabolic weakness is at the center of autism

There appear to be a number of metabolic weaknesses that have to be diagnosed, as there are wide variations among children with autism spectrum disorder. Ref. 4 points out that methylation defects in the metabolism are common and the blood is lacking antioxidant enzyme systems. As a result, there are weaknesses in the immune system and detoxification of heavy metals (such as mercury) is often slow. There have been many studies, which were reviewed in Ref. 4. It was shown that multiple vaccinations have not been the main culprit to lead to autism. It is the metabolic weaknesses of an autistic fetus and/or child that led to slow detoxification. This reaches a point where exposure to polluted air and seafood, even consumption of seafood of the pregnant mother in the womb, could cause high levels of mercury in the infant (due to methylation, sulfation, and antioxidant deficiencies).

Inflammation from a lack of omega-3 fatty acids

Another observation that is important is that children with autism spectrum disorder have 23% lower levels of omega-3 fatty acids in their blood than controls and 20% lower levels of polyunsaturated fatty acids (Ref.4). Omega-3 fatty acid supplementation is therefore important. As omega-3 fatty acids have anti-inflammatory effects, it also helps to combat the inflammation mentioned above. Ref. 4 also points out that autistic children are often put on a gluten-free, casein-free (GFCF) diet as autistic children are more vulnerable to food sensitivities, particularly gluten and casein. This is a practice to prevent or improve a leaky gut syndrome. However, Ref. 4 points out also that testing methods (RAST test, IgE and IgG tests) for gluten and casein sensitivities are unreliable and not reproducible.

Food elimination to identify food allergies

To find out what foods children with autism spectrum disorder will tolerate the physician uses a painstaking food elimination program. Whatever food component he/she suspects to cause worsening of autism is no longer part of the menu for a period of time. Several months later the physician reintroduces it as a challenge test to see whether it is still causing problems. The child needs balanced nutrition, which can be very tricky with autistic children. They often are picky eaters.

The key is to pay attention to all of these pieces of the puzzle. The treating physician must use remedies to address the issues at hand regarding a particular autism patient. This can be quite costly. But autism patients who received early intervention at the age of 2 or 3 became normal children. Early intervention with autism leads to more gifted children than the average child is in their age group.

Conclusion

Whether or not autism or the autism spectrum disorder exists is no longer the question. The question is how early the treating physician can diagnose it. Under point 7 above researchers found that the diagnosis of autism often occurs 18 months too late! With an early diagnosis and early intervention autistic children can grow up to be productive members of society. Often, they have no residual features of autism. If the physician misses the diagnosis of autism early on, it develops into a lifelong disability requiring constant care and supervision.

Epigenetic changes

I mentioned that epigenetic changes possibly from pollution and other factors can be responsible for autism. This may switch genetic switches into the wrong direction towards autism, autoimmunity, leaky gut syndrome and brain dysfunction. Children are much more sensitive than adults. This explains the explosion of cases of autism in the last few decades. Old age at the other end of the life cycle shows effects on the central nervous system. There is an enormous increase of dementia and Alzheimer’s disease in the last few decades. Could there be similarities? Future research will tell.

References

Use of progesterone reduces chance of miscarriage: next 2 references (Ref. 1 and 2):

1.http://www.bio-hormone-health.com/2012/03/26/the-key-role-of-progesterone-in-fertility-conception-and-maintaining-a-pregnancy/

2. Autism chapter in Dr. Schilling’s Nethealthbook.com: http://www.nethealthbook.com/articles/autism.php

3. More on DAN physicians: http://autism.about.com/od/alternativetreatmens/f/dandoc.htm

Apr

2013

On World Health Day 2013 the Focus is on Hypertension

By Ray Schilling | Diabetes, Eye Diseases, Fitness, Heart Disease, High Blood Pressure, kidney disease, Nutrition, Obesity, Prevention, Stroke, Vitamins and supplements, Weight loss

Introduction

This article is about this: on World Health Day 2013 the focus is on hypertension. In the US high blood pressure causes 348,000 American deaths per year, in the world its death toll amounted to 9.4 million every year. This is unfortunate as high blood pressure is an illness, which can both be effectively treated and prevented. Uncontrolled high blood pressure (hypertension) causes heart attacks and strokes, can cause kidney failure, heart failure and blindness. You control blood pressure with lifestyle changes and/or medication, and these risks go away.

The age standardized death rate (Ref. 1) for both sexes in the US for heart disease is 80.5 per 100,000 and for strokes 25.4. In Canada these rates are 66.2 and 22.9. For Germany the rates are 75.0 and 31.2, in Italy 51.7 and 34.9 and for Japan 31.2 and 36.7. The death rates from cardiovascular disease per 100,000 people in the same countries is as follows: in the US 172.2, in Canada 130.7, in Germany 200.2, in Italy 153.5 and in Japan 107.1.

There are obviously significant differences in these countries, which I will discuss further below.

Topic of high blood pressure

World Health Day was celebrated on 7 April 2013 to commemorate the founding of the WHO in 1948. In 2013 the topic of high blood pressure made the World Health Organization edit a PDF publication of 155 pages. It is entitled “Global Atlas on cardiovascular disease prevention and control” (Ref.1, be patient, loads slowly). In it prevention and treatment for high blood pressure are discussed in detail. This text points out that there has been a remarkable decline in death rates from heart attacks and strokes (collectively called “cardiovascular disease”) between 1981 and 2000 in the United Kingdom.

Decline in death rates from heart attacks and strokes

A thorough analysis of this showed that 58% of this decline was due to risk factor reduction in the whole population. This included reduction of smoking and heavy alcohol consumption, reduced salt intake, combatting physical inactivity and reduction of saturated fat intake. The other 42% of the decline in cardiovascular disease is due to treatment by a physician. So, it is clear from this that the majority of mortality prevention comes from the patient, less than 50% comes from the treating physician. However, it is important that physicians will educate their patients to cut out risk factors themselves in order to prevent hypertension.

World Health Day 2013, Focus on Hypertension

Risk factors for high blood pressure

On World Health Day 2013 the focus is on hypertension. In the past it was thought that most cases of high blood pressure would be due to “essential hypertension”, a term saying “we don’t know what causes high blood pressure”. Many physicians still use this term. Physicians thought that only a small amount of cases were due to “secondary” hypertension with an apparent cause (e.g. kidney disease, hormonal imbalance, pregnancy). But in the meantime research by Harvard University and other research institutions has shown that there are a number of specific causes that contribute to high blood pressure, either alone or in combination.

Common causes of high blood pressure

Here are the commonly known causes: too much salt in our diet; we tend to not eat enough vegetables and salads; we like to sit in cars, in front of the TV or in front of the computer (physical inactivity). Many people still smoke, although tobacco is known to cause high blood pressure and lung cancer. Too much alcohol is known to cause hypertension as well. So the following steps will prevent high blood pressure:

consuming less salt
eating a balanced diet (preferably the DASH diet)
engaging in regular physical activity
avoiding tobacco use
avoiding harmful use of alcohol (more than 2 oz. or 60 Grams per day)

Diabetes worsens the risk for heart attacks and strokes

Physicians know that diabetes worsens the risk for heart attacks and strokes and increases the risk of high blood pressure as well. So, some hidden risk factors for high blood pressure related to diabetes are as follows: a high fasting blood sugar; obesity; food with too much fat, too much sugar and too many starches (not enough complex carbohydrates).

What can we do to reduce death rates from high blood pressure?

As Canada is one of the countries where the death rate from strokes and heart attacks is lower than in the US or Germany, I like to point out some of the reasons for this. I practiced medicine in Canada for many years. The “Canadian Hypertension Education Program” have been guidelines for practicing physicians to follow providing effective screening and treatment of high blood pressure. Cardiologists at various continuing education conferences have promoted this.

High blood pressure recalls at my medical office

At my office I had a hypertension recall program where my staff called every patient with high blood pressure into the office every 3 months. We would review the home-measured blood pressure readings from the patient (recorded in a little booklet). I also took the blood pressure of the patient and so did my staff on the patient’s arrival. We reviewed the blood pressure medication and reviewed the possible side effects. I explained to the patient what to do, if the blood pressure was higher than normal (possible adjustments of the medication at home). I also encouraged my patients with regard to the life style issues (the 5 points mentioned above). Over the years the number of patients who developed heart attacks or strokes declined, as one would expect.

Literature review in the medical journal Canadian Family Physician

A recent review in the Canadian Family Physician mentions that there is room for improvement regarding the Canadian statistics. As mentioned above Italy and Japan are doing better with regard to mortality from heart attacks and strokes compared to Canada. We have a health care system in Canada that is available to every Canadian resident and funded by provincial taxes. In this system patients do not have to pay for office visits (although they pay for it indirectly through taxes). For the patient with high blood pressure, it means that there is a system in place, which helps prevent cardiovascular disease and treats high blood pressure effectively. In my opinion the home recording of self-measured blood pressure readings at least once per day with a home blood measure monitor is vital to encourage the patient to be engaged with regard to his/her blood pressure problem.

Newer findings about high blood pressure

For years physicians did not know where high blood pressure came from. In the last few years research has shown that nitric oxide plays an important role in preventing high blood pressure. The lining of your arteries produce nitric oxide (by the so-called “endothelial cells”). This is the natural artery relaxer.

Foods that produce nitric oxide in the body are spinach, kale, red beet, cabbage varieties and other vegetable greens. These foods, which are also contained in the DASH diet, and regular exercise will stimulate the lining of your arteries to produce nitric oxide, which prevents high blood pressure, heart attacks and strokes.

Treating high blood pressure with medication

If these measures and recommendations to prevent high blood pressure do not help, it is time to treat it. It is important that the patient who needs high blood pressure treatment with medication, takes the medicine regularly. This has the name”compliance”. By keeping the blood pressure reading below 120/80 you prevent your risk of getting a heart attack, a stroke, heart failure or blindness from broken retinal vessels. If the patient develops any side effect from the medication, it is important to see the physician about this right away. It may be that the medication has to be adjusted or altered.

Nitric oxide

Nitric oxide can be taken as a supplement (Neo40), which allows the endothelial lining to be regenerated as indicated in this interview with the inventor, Dr. Nathan Bryan from the University of Texas Health Center in Houston.

The older we are, the more likely it is that our blood pressure will be high. As this link shows, 2 out of 3 people above the age of 60 in the US have systolic hypertension (the upper value of the blood pressure is elevated). As we age, it appears that the lining of the arteries do no longer produce the required amount of NO (nitric oxide). NO is necessary to prevent high blood pressure and prevent hardening of the arteries.

Adopt the Mediterranean diet

So, it would be wise to adopt the Mediterranean diet. This includes lots of vegetables, spinach, kale, bok choy, Swiss chard and others to boost your NO production. You still measure your blood pressure regularly. If you do not have a home blood pressure monitor, go to a pharmacy that allows you to check your blood pressure for free. If it is above 120 over 80 seek the advice of a health professional. You can find more information in Ref. 1.

In essence, what World Health Day 2013 asks us to do is to pay attention to your blood pressure and make sure it is normal.

More on high blood pressure: http://nethealthbook.com/cardiovascular-disease/high-blood-pressure-hypertension/

References

Ref. 1) http://www.nethealthbook.com/articles/cardiovasculardisease_hypertension.php

Last edited Nov. 6, 2014

Apr

2013

Allergies Not Only In Spring

By Ray Schilling | Abdominal Pain, Allergies, Arthritis, Asthma, Cancer, Heart Disease, High Blood Pressure, Nutrition, Prevention

This article is about “allergies not only in spring”. Springtime is the time of spring allergies: those affected develop a runny nose, itchy eyes and in more severe cases they may experience a flare-up of asthma. Allergies can be triggered by the increase of pollen counts in the air that occurs every spring. In those who are sensitive, this leads to antibody formation in the blood. But often people have not only sensitivities to the pollens of spring bloomers; they may also be allergic to spores from molds, to dust mites and may have underlying allergies to foods.

Memory cells of the immune system

The immune system has memory cells that memorize that a person has had an allergic encounter to one of these items in the past, and allergic reactions can become more significant with a future encounter. Allergies often get worse when a person has food sensitivities and there are cross reactions between pollens of trees or grasses that share surface protein regions with similar protein regions in foods.

Cross allergies

It is known that cross allergies are possible between birch pollen and apple, carrots or hazelnut. In its extreme form allergies due to antibodies, called IgE antibodies, can cause anaphylaxis. A person presensitized by inhaling birch pollen, after eating an apple, hazelnuts or a carrot can develop itching of the throat, swelling of the lips and very quickly deteriorate getting into an anaphylactic shock.

Other cross allergies exist between ragweed pollen, which is a powerful inhalant allergen and melons or bananas. Again there are specific IgE antibodies that are responsible for this immune reaction. In this case the ragweed allergy primes the immune system to produce IgE antibodies, which are experience potentiation by certain foods that share similar protein components as the ragweed pollen.

In the following I will deal with inhalant allergies separately from food allergies.

Inhalant allergies

Inhalant allergies are easier to diagnose and to treat than food allergies. Your doctor will likely refer you to an allergist when you have allergies that do not respond to treatment with intermittent over the counter antihistamines. Your symptoms may come on in the spring with itchy eyes and a runny nose. From year to year you find that you become more and more dependent on antihistamines and nose drops to unplug your nose. The allergist likely will do sensitivity tests, which consist of skin prick or scratch tests on the back or the forearms.

Allergy shots to stabilize allergies

In more serious allergies, where the patient has coughing and wheezing attacks following allergic reactions, the allergist may suggest to start intermittent allergy injections alongside the standard inhalation therapy for asthma. The allergist prescribes an allergy serum where the lab mixes ingredients based on all of the positive tests that led to a strongly positive skin reactions through allergy testing.

Allergy injections

Typically, the family doctor or his nurse will start the allergy injections initially in weekly intervals. After reaching the maintenance dose, there may be a modification to injections every 10 to 14 days.

The allergy injections stimulate the immune system to produce harmless competing antibodies, which counteract the disease producing allergic antibodies. In the process of desensitization shots the immune system will normalize, which means that the inflammatory response of the immune system settles down to normal.

This is not the end of the story with inhalant allergies. The allergist needs to retest the patient on a yearly basis. The immune system changes all the time as new allergies can develop and old ones may go away.

Retesting allergies and sublingual immunotherapy

Retesting is necessary to keep track of what is going on and to change the composition of the allergy serum. Those patients who are working together with the allergist can do very well, and often they gradually outgrow their allergies. Others may not be so lucky. They may have reactions to the allergy injections. In these cases avoidance of what causes the allergy may be the only solution to treat the allergies.

There is an alternative to allergy injections, which physicians in Europe use, namely a sublingual immunotherapy. Recently there has been a review of the literature for FDA approval that is needed for oral desensitization for ragweed, dust mites, grass pollen and cat dander. It will take some time before the FDA approval process will become a reality for sublingual desensitization in the US.

Allergies to pets

A special form of inhalant allergies are allergies to pets (mainly dogs and cats, but also allergies to petting zoo animals). The dander that the human comes in contact with is a protein from the animal hair. It causes hives when it touches the skin. This occurs as the dander penetrates through the skin and meets the local mast cells that release histamine. This in turn is responsible for the hive formation. Sneezing and even asthma can develop from inhaled protein particles that reach the lungs. Allergy injections for the treatment of animal dander allergies often do not help or make the allergies worse. The allergist usually recommends avoidance of animal contact as the solution, a recommendation, which the affected animal lover often does not appreciate.

Allergies Not Only In Spring

Food allergies

Often we eat some foods more frequently, because they are our favorites. This means that our gut lymphocytes that get in contact with these foods can start to react to one or more of the foods we ingest. At this time we may experience abdominal cramps, diarrhea, vomiting and a host of other possible symptoms.

The physician will tell the patient that testing for food allergies is a problem. Most of the usual skin tests employed for inhalant allergies do not reliably work in determining food allergies. The doctor will ask the patient or the mother of the child with food allergies to keep a food diary and keep track of the allergic symptoms in the diary as well. An elimination diet will have to be devised based on the information gathered in the diary as it becomes clear from that record which foods cause which symptoms. The foods causing allergic symptoms are subsequently eliminated. This is a cumbersome process, but it is the most reliable method of testing and treating food allergies.

RAST test

In the past there was a blood tests, called RAST test, which tested for common food allergies that can cause severe allergic reactions like egg, milk, peanut, tree nuts, wheat, crustacean shellfish and soy. Since about 2010 this has been replaced by the more sensitive ImmunoCAP Specific IgE test.

Children often develop food allergies to egg, milk, wheat, nuts, peanuts and soy, which are food allergies with positive IgE tests. When they age, their immune system develops tolerance to many of these foods and they often outgrow these allergies.

Antibody tests for food allergies

Only a blood drop is necessary to test a panel of foods with IgG, IgM and IgE antibodies. A number of suppliers offer these tests. However, the specificity, sensitivity and reliability can pose problems with regard to the interpretation of the results. Allergists often point out that a test may be a false positive when a person likes certain foods. IgG antibodies against this food show up despite the patient having no symptoms. Another specialist may interpret this to indicate that the body shows early sensitization to a certain food. However, clinically it is not yet obvious. In other words, the sensitivity of the test is so high that it undermines the validity of the test. Recently a panel of international scientists reviewed the validity of these IgG based food intolerance tests and they found the tests not reliable.

Testing for food allergies

The immune responses to food allergies are complex as there are immediate type immune reactions and delayed type immune reactions. The physician investigates the immediate immune responses with the above mentioned ImmunoCAP Specific IgE test. The delayed immune responses can be measured using the ELISA test.

Other considerations about allergies

You see from this discussion that a patient with allergies needs a properly trained allergist who will do a comprehensive analysis involving a thorough history, examination, blood tests and immune tests. The specialist interprets the test results, which requires his/her experience and clinical judgment.

Clearfield wheat

Since the 1970’s when Clearfield wheat was introduced around the world on a large scale, which has a much higher gliadin (gluten) content than the old wheat varieties. As a result of exposure to this new type of wheat gluten intolerance and leaky gut syndrome have increased. Scientists registered a substantial increase in wheat gluten intolerance in the world population. Genetically modified foods like soy, corn, sugar beets, canola and more are a challenge for the immune system. This is particularly so in sensitive humans. Physicians do not fully understand why this is so. We do know that some people can develop autoimmune diseases. This may be the reason that a host of diseases are much more common now than in the past. Common autoimmune diseases are MS, rheumatoid arthritis, Hashimoto’s thyroiditis, ankylosing spondylitis and others.

Epi-Pen, chronic inflammatory diseases

After food elimination for 2 to 12 months depending on the severity of the food allergy, your body may have eliminated the allergy to the food you have avoided, in other words your body built up tolerance. Before you expose yourself to any food that you used to be allergic to and that you want to re-test, it is best to have an EpiPen ready in case your allergy has not resolved. Caution is necessary with regard to foods that cause more severe allergies, e.g. shellfish or peanuts. These type of allergies may last life long. It is safer to avoid these foods that cause more severe allergies altogether.

Chronic inflammatory diseases

Allergic reactions of the immune system belong into the category of chronic inflammatory diseases. These are known to be the root of chronic diseases like asthma, arthritis, heart disease, high blood pressure and cancer. Be vigilant about allergies and get proper assessment and treatment by an allergist. You will prevent serious health problems including the above mentioned chronic diseases.

More on asthma, which is a chronic inflammatory lung condition, often associated with multiple environmental allergies:

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Apr

2013

Caution, Processed Food Ahead

By Ray Schilling | Alzheimer’s disease, Anti-aging medicine, Cancer, Diabetes, Health, Heart Disease, High Blood Pressure, Medical Condition, Nutrition, Obesity, Prevention, Stroke

Introduction

The title of this review is: caution, processed food ahead. During the last month there have been three large studies that drew media attention regarding healthy food intake. The first study dealt with processed meats (sausages, ham, bacon). Over 12.7 years those consuming 160 Gm per day (=5.64 oz.) were 44% more likely to die prematurely than those who ate only 20 Gm (=0.7 oz.) of processed meat per day. The study included 10 European countries including about 500,000 people over almost 13 years; nearly 10,000 people died from cancer and 5,500 from heart problems.

Harvard study

Then there was the Harvard study that analyzed 114 national dietary surveys around the globe and came to the conclusion that every year there are 180,000 obesity related deaths from overuse of sugary drinks. The US stands third highest on the ranking list regarding deaths from drinking sugary soda pops. The deaths are due to heart attacks, strokes and diabetes, which associate with obesity.

15% of all death around the world from salt overuse

As if this was not enough the third bad news story came shortly after story about salt overuse: At a cardiology conference in New Orleans Dr. Dariush Mozaffarian, the main author regarding the sugar study mentioned above, revealed a long-term study regarding salt intake between 1990 and 2010 . He determined that 15% of all deaths that occur around the world every year (which translated into 2.3 million people) are the result of salt overuse. The recommended salt limit is 1500 mg per day. But many people in the study consumed 4000 to 6000 mg of salt per day or more. This led to hypertension, heart attacks and strokes with the yearly mortality rates indicated.

Caution, Processed Food Ahead

What do these studies have in common and why is processed food so devastating?

All these studies pointed out that processed foods are dangerous to your health. Sausages, ham and bacon contain a lot of fat and salt; they are full of extra calories and they elevate your fatty substances in your blood (triglycerides, cholesterol). The extra salt raises your blood pressure. Processed meat is also poor in omega-3-fatty acids. No wonder that they can cause heart problems and cancer.

Sugar and processed food

Next, we have the sugary soda drinks, but also the hidden sugar in starchy processed foods like cookies, bagels, bread and cakes. Dough and pasta digests within 30 minutes into sugar, which your gut absorbs and your liver processes as extra calories to be stored as fat. Where? As visceral fat and subcutaneous fat, and the end result is obesity. At the same time the sugar from soft drinks and the sugar from starches stimulate the pancreas to produce extra insulin, which leads to hyperinsulinemia and insulin resistance. This is known as metabolic syndrome and was found to be an independent risk factor for heart attacks apart from high LDL cholesterol and high triglycerides. We know for quite some time that obesity, diabetes, insulin resistance and metabolic syndrome are all associated with a higher rate of deaths from heart attacks and strokes.

Salt overuse

Finally, there is the salt overuse story. In 2009 the same Harvard group that gave us the world data on salt mortality now, stated that 102,000 Americans die every year from salt overconsumption. The same study cited that 82,000 Americans die needlessly every year due to their love affair with deep fried foods (due to high trans fatty acids) , and 84,000 die from a lack of omega-3-fatty acids in their diet, which when present in the diet protects from heart attacks and strokes.

Food processing

What does food processing do? It reduces or eliminates dietary omega-3-fatty acids, adds cheap oils containing omega-6-fatty acids (the fatty acids that lead to inflammation), adds salt, sugar and starch. It is the perfect recipe to die from strokes and heart attacks. The same research group from Harvard University did a study in India, published in 2010, where they established that salt over consumption caused insulin resistance and this was the cause of higher mortality from heart attacks and strokes.

Other studies pointing to the dangers of processed food

Deficits in cognitive function (dementia or Alzheimer’s disease) are associated to dietary habits, particularly sugar and starch overconsumption. Research has established that hyperinsulinemia or insulin resistance is responsible for the degenerative changes in the brain of Alzheimer patients. This study also pointed out that these diets are typically very low or deficient in omega-3-fatty acids, which is necessary for normal nerve cell metabolism in the brain. The lack of it leads to brain cell disease like Alzheimer’s and a lack of omega-3 fatty acids in nerves leads to damaged nerves which in turn cause excruciating pain.This condition is also known as neuropathy.

Gout was around in the Middle Ages

In the Middle Ages it was first observed that overindulging in red meat and sausages caused gout attacks. A nickname for gout was “a disease of the rich”. Higher uric acid levels, which are found in gout have been linked to higher mortality rates from heart attacks and stokes. A low purine diet can lower the risk for gout and also the risk for heart attacks and strokes. It is interesting that this type of a diet is also devoid of processed food at the same time.

What can we do to reduce dangers to our health?

We have identified the suspects; it is sugar, starchy foods, salt and processed meats. Instead of just buying precooked meals, boxed foods and other processed foods from the center of the grocery store or from a fast food place, look for original ingredients more at the periphery of the grocery store. Read food labels and look for sugar, fat and salt content. Start buying organic food and buy the ingredients you need to prepare a meal by yourself. When you start preparing your own meals with organic ingredients, you may as well avoid the toxins that I described in a recent blog.

Buy organic foods

By buying organic foods, you largely avoid these toxins. Don’t exceed your daily limit of 1500 mg of salt, as your kidneys are not able to process this and would cause you to get high blood pressure. Personally, I cut out all sugar and starch from my diet since 2001. This includes potatoes, pasta, bread, bagels, French fries, toast etc. However, you will get enough complex carbohydrates (from vegetables and greens). The body absorbs them much slower and does not cause the insulin surge by the pancreas. In contrast, highly processed carbs lead to an insulin surge.

Omega-3 fatty acids important for health

You want to eat foods rich in omega-3-fatty acids, but seafood (even salmon) has a contamination with mercury. You can circumvent this by taking 3 or 4 capsules of high potency, molecularly distilled omega-3 per day. This is free of toxins and protects your brain and nerves from the dangers mentioned above. Your organic vegetables/greens have enough natural minerals that you will seldomly want to add salt to your food. Do not add extra salt when you cook or when you eat your prepared meals. Use spices instead. Also avoid eating out too often. Restaurants are notorious for overusing salt.

More information

More information on nutrition: http://nethealthbook.com/health-nutrition-and-fitness/nutrition/

My Experience With Cancer Research

By Ray Schilling | Cancer, Health, Nutrition, Prevention, Vitamins and supplements

This article is about my experience with cancer research. April is cancer awareness and fundraising month. I thought it would be interesting to analyze what’s going on behind the scenes of cancer research. I was a cancer researcher for over 3 years at the Ontario Cancer Institute (OCI) from 1972 to 1975 and I will share some insider experiences here.

1. Publish or perish

Our supervisors said: “publish or perish”. In other words all the experiments we did needed to fit into the larger picture the group was working on. And the results should be different, interesting and most of all publishable. There had to be significant differences between experimental groups and controls. This was a requirement by publishers of medical journals would accept them for publication. There were often two or three manuscript revisions where the content was “massaged”. I had to pay attention to proper wording and comparing or opposing the results with other publications. This way the publisher deemed the manuscript “publishable”.

2. Fund raising awareness

One of the major fund sources for cancer research in Canada was the MRC (Medical Research Council of Canada), which has been replaced by the Canadian Institutes of Health Research (CIHR) in 2000. Without money there is no cancer research, so everybody was aware of the policies and expectations of the fund source.

3. Mouse model versus human tissue based research

My work was in the immunology section of the biophysics department, where researchers perform basic medical research at the OCI. In this department much research had already been performed separating cell populations in a mouse model to determine what cell types were needed to initiate an immune response. The B cells in mammals are antibody-producing cells of the immune system that protect from viruses. T cells are lymphocytes, which the body processed in the thymus. They turn into killer cells, which can attack parasites and also cancer cells. I was working in this area.

Cell separation experiments and doubts about mouse research

We did cell separation experiments. With this method I was able to separate cells according to cell size and collect them in vials. Subsequently I did remix experiments. The purpose was to find out which cell types were able to mount an immune response. My supervisor suggested the use of a mouse tumor cell line as targets. I started questioning whether a mouse model would be the appropriate model to study human cancer biology. But my superiors were not in agreement. The “holy grail” was that to work in a mouse model (mouse mammalian cells). The assumption that this should also work in the human situation (human mammalian cells).

My Experience With Cancer Research

4. Non-medical researchers in cancer research

This is a thorny issue, but a reality. My immediate supervisor in cancer research had a PHD in physics. His physics degree was perfect for sorting out density issues for cell separation experiments. The co-chair of the immunology department had a PHD in biology. His qualification was good for conducting mouse experiments. Both of them felt somewhat insecure when I asked questions. I wanted to know how relevant mouse experiments were for the examination of human cancer conditions. As I needed to publish my experiments, I had to quiet down and concentrate on the mouse model the team was working on. For a while this could even be exciting as we were studying the cell interaction between macrophages and T cells to mount a cell-mediated immune response.

5. Regulation of the cancer research industry

After playing with cell cultures for 2 ½ years it was time for me to reach out to get a job in the cancer research field or else go back to medicine. In1975 there was no equal opportunity legislation in place that would have protected me as a landed immigrant from discrimination. The reality in 1975 was that only Canadian born physicians who attended a Medical School in Canada could become a director of a cancer research facility in Canada. The rules for me (I had left Germany right after my rotating internship) were that I had to go through further medical training and pass the Canadian licensing exam (LMCC), which I did eventually at McMaster University in Hamilton, Ontario.

Interview with Dr. McCulloch

One final attempt to shed light on my options was an interview with the “big boss” at the Ontario Cancer Institute at the time, a physician cancer researcher, Dr. Ernest A. McCulloch, for whom I had great respect. He was a sharp thinker and had vision, and he was a fellow physician. I asked him what he would do on the long-term, if he was in my place. He said that in the long-term with my medical background it would be a lot more satisfying for me to get back into medicine and practice medicine. However, he wanted me to go on for another 1 or 2 years and publish more papers together with my supervisors.

My decision to leave cancer research

I decided for myself right there that I would leave cancer research and I prepared quietly for my exit. Within a short time I got a position to work as an intern at a hospital at McMaster University and in the spring of 1978 I passed the LMCC (licensing) exam. As a fully licensed physician in Canada, I was no longer interested in “slave work” in cancer research. I also left the cold winters of Ontario behind and went to the west, to British Columbia.

6. Future vision of medical cancer research

Research has come a long way. Recently I came across a new breast cancer protocol, which is non-toxic, without chemotherapy and without radiation. It is so unconventional that the US research team, aware of the politics in the US, decided to do the initial trials in the Caribbean. I wrote a blog about this new breast cancer treatment protocol, which I believe will become the future standard for breast cancer therapy and perhaps even for other cancers.

Alternative breast cancer treatment

In Germany and Switzerland an alternative breast cancer treatment consists of with mistletoe extracts. This is a non-toxic plant chemotherapy, which slows down tumor growth. It has a dual action, namely a chemotherapeutic effect, but at the same time an immune system stimulating effect. Here is a study going back to 2001, which is still relevant. There was a 40% long-term survival benefit in the Iscador group when compared to a control group without treatment. Normally, oncologists jump at such an excellent chemotherapeutic agent as they even consider chemotherapeutic agents that with a 25% beneficial survival effect a good treatment option. However, as the medication is a simple mistletoe extract and cannot be patented, Big Pharma is not interested in marketing this. As a result cancer treatment protocols in Europe are significantly different from those in North America.

The future of cancer treatments

In the future I would expect that non-toxic treatment methods for any type of cancer will be more successful than any chemotherapeutic or radiation treatment approaches as both interfere with the immune function, which is what will kill the patient at the end. Cancer is a disease where the immune system fails. So, cancer patients need teaching how to stimulate their immune system. This is the only thing that controls cancer on the long-term.

You will hear more about epigenetic switches as often a cancer producing substance will turn off a gene (epigenetic switch) and this causes cancer. Remove what throws that switch into the off position or introduce a healing agent that resets the switch and the cancer will get eliminated.

7. Prevention of cancer

Researchers noticed that herbs, spices, vitamins and minerals contain the most powerful cancer preventatives. Did you know that curcumin, derived from the Indian spice turmeric, prevents a number of cancers? Similarly, vitamin D3 at high enough doses (4000 to 5000 IU per day) has been shown to prevent cancers. Linus Pauling showed long time ago that vitamin C at high enough dose would be an antioxidant and would stimulate the immune system and thereby be a cancer preventative. It works together with a detoxifying antioxidant, glutathione in the liver to neutralize any free radicals, which are aggressive chemicals that cause cancer.

Learning from risk factors for cancer

There are many other vitamins and minerals that I have explained elsewhere, which are needed together with organic food to give you the building blocks for a stable cell metabolism. This in turn will strengthen the immune system to defend you from toxins of the environment. A simple step like a daily exercise routine can cut your cancer risk down to 50% compared to those who elect to not exercise. Did I mention the importance of quitting smoking and cutting out alcohol? The “quit smoking” part has been known for some time.

Alcohol is a cell poison and can cause cancer

At the Anti-Aging conference in Las Vegas in December 2011 I learnt about the importance of alcohol exposure that causes cancer. Even smaller doses of alcoholic beverages over a long period of time can cause cancer. First I thought it would be a big deal to quit alcohol entirely. But since I have quit the modest few drinks per month, I actually have not missed them at all! I strongly believe in cancer prevention, so quitting alcohol completely was only one small step in this overall objective. In view of the recent statement by the WHO that 70% of all deaths are caused by smoking and drinking of alcoholic beverages, it behooves us to change our lifestyles, if we are at all interested in a healthy long life.

Conclusion

Nothing has changed in cancer research circles since the time when I was part of it. Basic cancer research involving animal experiments is necessary. But in my opinion cancer research should be more human-centered using human cell lines in culture and using clinical trials. Ultimately cancer research needs to invent and develop new non-toxic cancer therapies to cure cancer patients.

More on cancer in general and on specific cancers: http://nethealthbook.com/cancer-overview/

Last edited Nov. 6, 2014

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Mar

2013

Living In A Toxic World

By Ray Schilling | Cancer, Health, Heart Disease, Hormones, Nutrition, Prevention, Vitamins and supplements

The following article is about living in a toxic world. In the past nobody worried about toxicities except parents when their children were gnawing on lead paint. Paint always contained lead and people thought that it was only children we had to worry about. We thought that adults were “immune” to this. We learnt a lot about lead toxicity from early studies in Germany and it was there that EDTA was developed in 1935 to treat children with lead toxicity. During the Second World War when ships were painted with lead containing paints many soldiers were poisoned with lead. EDTA treatment protocols that had been developed earlier for children were found to be also effective for these soldiers.

Lead poisoning from Chinese made toys and mercury poisoning from the air

Fast forward to 2013. We all have heard of lead poisoning from Chinese made toys, from Chinese fashion jewelry and we have heard of the melamine poisoning of baby food and candies. These are not the only poisonings. Mercury is in the air; it is also present in light bulbs and in cruise ship exhaust fumes from incineration of light bulbs and batteries. We have over 600 chemicals and carcinogens in cigarette smoke, which is perhaps the largest “legal” roulette game involving humans where several poisons are inhaled at once. Our water is chlorinated or fluoridated, which interferes with our thyroid gland function. Vegetables that are supposed to be healthy for us contain residues from insecticides and herbicides that have estrogen-like activities called xenoestrogens.

Xenoestrogens can cause breast cancer

They are known to cause breast cancer in women and prostate cancer in men. Milk in the US often contains antibiotics and genetically modified bovine growth hormone (rBGH), which again can cause various cancers in humans as this link shows. rBGH is banned in Europe and in Canada. The problems do not stop at chemicals in our water, environment, food and air, the newest threat is genetically modified food like wheat, corn and high fructose corn syrup, which is manufactured from GMO corn. Other GMO foods are golden rice, sugar beet, yellow crookneck squash, cotton for cottonseed oil, soybeans, canola, Hawaiian papaya, just to name a few. GM food is illegal in most European countries, but the US is trying very hard to push for “fair trade practices” in order to expand the market for GM foods.

Living In A Toxic World

GMO and endometriosis

How does all of this affect your body? One of the publications from France found that genetically modified food is likely responsible for the increase of endometriosis in women. This link explains that xenobiotics-associated genetically modified foods contain glyphosate (a herbicide) and Cry1Ab protein that affects the women’s hormone metabolism and causes the lining of the uterus to become invasive to cause endometriosis. There have been attempts to study toxicity of GM foods in animal experiments, but the pitfall was a wrong testing time of only 90 days , which was chosen for these experiments, and “no differences” were found between test and control animals (all the official statements about GMO food “safety” in the US are based on these “standard tests”).

The effects of GMO food

However, there are other studies that found significant differences after only 4 weeks of feeding rats and mice 10% GMO food mixed with regular feed as this link shows. The full impact of genetically modified foods is not evident until 3 generations or more in animal experiments, which is the equivalent of 90 years or more in humans. This is 80 years from now because significant amounts of GM food were in the food chain from the food industry for about 10 years. The definition of one human generation generally is 30 years. The animal studies show that with GMO food there is a higher mortality in rats and mice and that infertility is getting worse from generation to generation.

Toxic effects of heavy metals

With respect to chemicals patients detect toxic effects on the body a lot faster than with GMO foods. The toxins such as carcinogens and xenoestrogens are often fat-soluble, which means that obese people have more toxins stored than lean people. Mercury, cadmium and lead were found in a study to have caused specific protein folding problems within the cells. This explains bone marrow toxicity, liver and kidney toxicity and brain and heart toxicity. In other words, these are the organs where cells contain most of the mitochondria in the body and heavy metals are blocking their energy metabolism leading to aberrant body functions. As a result auto-immune diseases have increased dramatically, inflammatory conditions are common, and cancer rates are up.

How do we defend ourselves in a toxic world?

1. Food preparation living in a toxic world

First you need to switch from regular foods to organic foods. Also throw out all the foods in your fridge that are not organic and that contain MSG in it’s many disguises. MSG is an excitotoxin, which kills brain cells. These suggestions are also what Dr. Paula Baillie-Hamilton is recommending. Organic foods do not contain any of the problematic GM foods. They are also free of rBGH, xenoestrogens, residual herbicides or residual insecticides. Switch to either organic milk and milk products or goat milk and goat milk products. As some toxins will be released from the fatty tissue, if you are obese or overweight and you loose weight, it is advisable to use psyllium seed husks as a supplement to bind the toxins in the gut for elimination. Fiber from organic fruit and vegetables or oat bran are also beneficial.

Buy organic, avoid restaurants

On the long term it is less money to buy organic foods and prepare your own meals than going out to restaurants to eat. It is also much healthier and tasty. Avoid fast food chains as their processed foods contain artery clogging trans fats, GM foods and other questionable ingredients like “pink slime”. You do not need a cooking class to prepare a decent dinner. Read cookbooks for inspiration and modify the recipes to suit your own style. Remember to use only organic ingredients. You can’t create a healthy meal with non-organic ingredients mixed in (it’s like you start adding poisons). Break the old habits, do it right! Replace butter with olive oil. Replace sugar with organic stevia (a plant sweetener).

Avoid wheat flour

Avoid flour (especially wheat flour). Replace it, if you must with flour from oats, spelt or farro (at this point none of them have undergone genetic changes). Because wheat has been chemically modified in the 1960’s and 1970’s and gliadin is about 7-fold higher, brain receptors react differently than to the “old” wheat. As a result many individuals find that they want more- bread, pasta, wheat cereal, bagels…you name it! The huge surge in obesity is just the final result. Cutting out wheat and otherwise reducing the intake of grains may be a big step, but is well worth the effort! Another problem with bakery products is that the food industry is using bromine for rising and chlorine for bleaching so this adds to the toxic burden of the thyroid gland. Cut out wheat, pasta and bread and you will gain health.

2. Detoxification living in a toxic world

If you had a lot of exposure to heavy metals in the past, you may want to see a naturopath for intravenous chelation treatments with vitamin C (10 Grams) and glutathione (1250 mg) every two weeks for some time until they are out of your system. If you have a lot of silver/mercury amalgam tooth fillings, let your dentist remove them. Ask your dentist to replace them with non-amalgam ceramic, gold inlets or crowns. Don’t use fluoride toothpaste despite your dentist’s recommendation: it is toxic as it poisons enzyme systems in your body and causes cancer of the intestines over a longer period of time. Use a fluoride-free toothpaste from the health food store. After dental cleanings refuse the fluoride gel for the same reason. Brush your teeth frequently and floss your teeth regularly after meals. Your heart and cardiovascular system will thank you for this.

3. Eliminate other toxins from your personal care products

Check your cosmetics, shampoos, hair conditioners as well as your underarm deodorants, body wash, lip balm and sun tan lotion. Do they have parabens, triclosan (often in deodorants) or phthalates in them? They are weak carcinogens or immune disruptors. If they do, replace them with a healthier product from the health food store that does not contain these harmful ingredients. Use BPA free plastic containers for water during sport activities, they are quite affordable and can be ordered online. BPA free food containers are also available in super markets, department stores and some drug stores.

4. Clean up your home environment

Avoid toxic cleaning agents, solvents, paints, and other chemicals. If you have to deal with chemicals, be sure to ventilate your living spaces. Use latex paint instead of oil-based paint, if possible and air out well until dry. Always use vinyl gloves to protect your skin. The body absorbs thinners or paints through the skin within a few minutes and are toxic to your system. If there is construction in your house or you move into a new home, air out frequently by opening the windows on and off until the “new” chemical odors disappear. New clothes contain chemical agents from the factory; wash them frequently until the chemicals disappear. Avoid fabric softeners as they are chemicals (or use a biological product, if you feel you must use one).

5. Pay attention to your water living in a toxic world

The water utility company treats drinking water with chemicals (fluorine, chlorine or bromine) to make it bacteria free. It is best to drink only reverse osmosis water, bottled water, distilled water or mineral water. Home owners are doing well to remove for the rest of the household fluoride, chlorine or bromine from the tap water. with A good carbon filter can do that for you. Talk to your water treatment company.

6. Hormone balance living in a toxic world

The aging process and the toxins in our environment affect our hormone glands and we produce less hormones as we get older than our ancestors did, but our ancestors overall did not live as long as we are today. A lot of this is due to exposure to immune disruptors like BPA’s from the older water bottles and long-term exposure to xenoestrogens (from residues of artificial fertilizers on non-organic vegetables).

You need balanced hormones

We need balanced hormones; it is important to have them checked by a knowledgeable doctor. Either an A4M anti-aging physician, a naturopath or a functional medicine physician can help you. Replace missing hormones only by bio-identical hormone creams, not by synthetic factory produced pseudo-hormones. Common problems as we age are hypothyroidism, sex hormone deficiencies both in women and men, but also human growth hormone deficiencies in some (measured by IGF-1 blood levels). Without proper hormone balance all the organic food in the world will not be the answer to good health.

7. Vitamin and mineral supplements living in a toxic world

Finally, vitamin and mineral supplements are important to support the mitochondria in your cells. Although no vitamin and mineral list is ever complete, I have summarized what I consider to be essential here. Start simple with only vitamin C, omega-3 fatty acids, vitamin D3 and a multiple vitamin and mineral supplement. You can always add more later.

The only other thought is to take a slow-release capsule of iodine twice per day. This would protect you from radioactive iodine in the environment or food. Compounding pharmacies may be your best source. One capsule generally contains 5 mg of elemental iodine and 7.5 mg of iodide. As time goes on you may want to gradually investigate the other supplements. See whether they would be suitable in your particular case.

How to age gracefully

We all would like to enjoy a long and happy, disease-free life. This goal is no longer achievable by sticking to the old eating habits. Needless to say, that smoking and drinking are out too, because they are toxic to your system. You may as well enjoy organic foods and gradually work yourself through the 7 points I mentioned above. This will ensure that the mitochondria of all your major organ systems will function at their best. As a result, you will feel energized and age gracefully!

More information on vitamins, minerals, supplements and detoxification:

http://nethealthbook.com/health-nutrition-and-fitness/nutrition/vitamins-minerals-supplements/

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Mar

2013

Calcium, Vitamin D3 and Vitamin K2 Are Needed For Bone Health

By Ray Schilling | Fitness, fractures, Hormones, Osteoporosis, Prevention, Vitamins and supplements

Introduction

I am reviewing in this blog why calcium, vitamin D3 and vitamin K2 are needed for bone health. Recently there has been a lot of coverage in the press regarding postmenopausal treatment of women to prevent osteoporosis. It is all based on this original publication February 26, 2013.

Essentially, there are a number of studies where researchers did a meta-analysis of several trials. They studied osteoporotic bone fracture frequency in female subjects taking 400 IU vitamin D and 1000 mg calcium daily. The researchers measured the frequency of osteoporotic fractures as the indicator for osteoporosis in these postmenopausal women. The conclusion was that there was no value in taking these supplements to prevent osteoporosis. Many other media publications carried this story.

No kidney stones in study with calcium and vitamin D3

Just two days earlier (Feb. 24, 2013) another study was released with a much larger patient base of 36,282 postmenopausal women of the Women’s Health initiative in the US who were followed up for 7 years. Initially there confusion how compliant the patients were taking their supplements. The required supplementation consisted of 1000 mg of calcium carbonate and 400 IU of vitamin D3. 7 years into the trial the researchers compared the supplement compliant group with the control group taking placebos.

Calcium and vitamin D3 supplementation significantly reduces risk of hip fractures

The study group had 35% to 38% less fractures of the hip than the placebo group. This supplementation did not cause kidney stones in the study group. This was in contrast to what previous smaller studies showed. Some physicians insisted citing the older studies that vitamin D3 and calcium supplementation would cause kidney stones. But the above study refutes the causation of kidney stones by supplementing with vitamin D3 and calcium. In other words, all of these kidney stone concern you have so often read in the media are not true.

Outline of this review

In order to make sense of supplementation as osteoporosis prevention I will first review what a normal bone metabolism requires. I will then comment on what is missing in some of the studies and why it still makes sense to supplement to prevent osteoporosis. In addition, at the end of this blog I will also recommend a sensible supplementation regimen. All this is based on a balanced review of the medical literature.

Calcium, Vitamin D3 and Vitamin K2 Needed For Bone Health

Bone metabolism

But vitamin D3, vitamin K2 and strontium together have also been shown to build up bone density within one year.

So, how does vitamin K2 deposit calcium into the bone? Vitamin K2 stimulates a hormone, called calcitonin, which is produced by specialized C cells (parafollicular cells) inside the thyroid gland and released into the bloodstream. Calcitonin arrives in the bone where it binds firmly with receptors of osteoclasts (bone remodeling cells), which stops breakdown of bone. Calcitonin is helped by another hormone, called osteocalcin, which is produced by the bone producing cells with the name osteoblasts.

Vitamin K2 controls osteocalcin, which is a calcium-regulating hormone

The physician can measure osteocalcin levels in the blood and use this as a research tool to see whether a medication is effective in building up bone mass density (BMD). Vitamin K2 control osteocalcin as a calcium-regulating hormone. If vitamin K2 is present, carboxylation of osteocalcin will lead to mineralization of the bone (new bone formation); if vitamin K2 is absent, osteoporosis sets in.

The skeleton of an average adult contains 1–1.3 kg of calcium and 99% of this is mostly in the form of hydroxyapatite.

The key vitamins for bone metabolism are vitamin D and vitamin K2

Calcium absorption from the small intestine requires vitamin D3 (Ref.1). To transport calcium from the blood into the bone we require both vitamin D3 and vitamin K2 (=menaquinone). This blog explains that several studies have shown that vitamin K2 (or MK-7) plays a double role of preventing calcification of the arteries and bringing the calcium into the bones of osteoporotic women.

Apart from Vitamin K2 that is necessary for osteoporosis prevention other factors have shown to be of importance. For instance, testosterone is an anabolic hormone (meaning a hormone that builds up) and it has clearly been shown that it is bone building: It does so by stimulating osteoblasts, which are bone producing cells that reside inside the bone.

Vitamin D3, vitamin K2, Calcitonin and osteocalcin

But vitamin D3, vitamin K2 and strontium together have also been shown to build up bone density within one year.

So, how does vitamin K2 deposit calcium into the bone? It does so by stimulating a hormone, called calcitonin, which is produced by specialized C cells (parafollicular cells) inside the thyroid gland and released into the blood stream. Calcitonin arrives in the bone where it binds firmly with receptors of osteoclasts (bone remodeling cells), which stops breakdown of bone. Calcitonin is helped by another hormone, called osteocalcin, which is produced by the bone producing cells with the name osteoblasts.

Vitamin K2 controls osteocalcin, which is a calcium-regulating hormone

Osteocalcin levels in the blood can be measured and used as a research tool to see whether a medication is effective in building up bone mass density (BMD). Vitamin K2 controls osteocalcin as a calcium-regulating hormone. If vitamin K2 is present, carboxylation of osteocalcin will lead to mineralization of the bone (new bone formation); if vitamin K2 is absent, osteoporosis sets in.

Vitamin K2 also prevents heart attacks and strokes

Vitamin K2 has a second function: it removes calcium from the arterial walls and tissues. How does it do this?

Matrix GLA protein is found in tissues of the heart, lungs, kidneys and blood vessels. When vitamin K2 stimulates carboxylation of this protein, it will function like a broom and clean out calcium deposits (calcification) from blood vessels and organ tissues. As vitamin K2 is needed for this carboxylation process, it appears that nature had in mind to remove calcium from soft tissue organs and blood vessels and form hydroxyapatite in the bone for bone strength.

Vitamin K2 is the key to deposit calcium into the bone

It seems that vitamin K2 is the key vitamin necessary to do this job. Another player is magnesium, which is part of of the normal function of more than 300 cellular enzyme systems. In terms of hormones the three hormones parathyroid hormone (PTH), vitamin D3 and calcitonin need to interact normally, all requiring magnesium as cofactor. In addition, zinc, copper, boron, and manganese are also essential as trace minerals. They act as cofactors with regard to specific enzymes of the bone metabolism (Ref. 1).

Bioidentical hormone replacement essential after menopause and andropause

In the aging person hormonal deficiencies are also factors for causing osteoporosis to develop. As this link shows, Dr. John Lee found bioidentical progesterone topical cream very helpful in women with respect to increasing bone mass density by 15% over 3 years.

When bloods tests show testosterone depletion men need to replace what is missing with bioidentical testosterone. So, bioidentical hormone replacement in both men and women is part of a bone health management program to prevent osteoporosis.

Some trials that demonstrate how you can build up bone

In this paper parathyroid hormone was used in combination with 1000 mg of calcium and 400 IU of vitamin D3 in a group of postmenopausal women with osteoporosis. Within 3 month of treatment there was an increase of bone mass density in the lower back (lumbar spine) of 4.7%, which translates into a yearly increase of bone mass density of 18.8%. In the past when physicians tested other agents for bone regeneration, this type of result never occurred. There is a variation of this hormone, a parathyroid hormone look-alike with the name Teriparatide (PTH 1-34). The patient administers this once daily as an injection of 20 mcg up to 2 years. Physicians found this useful in treating fractures of the vertebrae and other fractures in osteoporotic postmenopausal women (Ref.2).

Effect of Vitamin K2, estrogen and calcium citrate supplementation

This publication tells the story of how bone was built up just by adding vitamin K2 to the diet in a varied patient population from children to middle aged and older individuals with a variety of osteoporotic conditions in Mumbai, India.
In this paper the various effects of estrogens, selective estrogen receptor modulators, calcitonin and strontium ranelate were investigated with regard to their ability to build up bone when severe bone loss was caused by end stage osteoarthritis.
Postmenopausal women who received 800mg/day of calcium citrate, along with various levels of intensity of a structured exercise program, increased their muscle mass by 11% to 21% and increased their BMD by approximately 2%.

Calcitonin and calcium strontium

Calcitonin is very effective in reducing bone pain when the patient has compression fractures from osteoporosis; the physician can prescribe it as an intranasal spray of 200 units daily (Ref. 2). However, on March 5, 2013 the FDA announced that salmon calcitonin would not be safe for humans as there is a slight risk that cancer can develop as a “side-effect”.
According to Ref. 2 physicians sometimes use strontium ranelate in Europe for the treatment of postmenopausal osteoporosis. Researcher showed that strontium ranelate builds up bone and decreases the amount of bone resorption. Side effects include nausea and diarrhea.

The team players of bone metabolism to build strong bone

We are now in a position to analyze why the researchers of the first paper (citation above) concluded that calcium and vitamin D3 supplementation were not enough to make a statistical difference in the treatment of postmenopausal women in comparison to placebos. As explained bone metabolism is a complex process involving several team players, where the key player is vitamin K2, which the researchers of that study ignored completely. The examples I mentioned above in point form show that exercise and calcium are also important. Vitamin K2 by itself worked quite well as it is so powerful. Hormones like PTH and calcitonin are effective, but more difficult to take for the average consumer and the FDA now has banned calcitonin.

Importance of vitamin D3 as a supplement

Vitamin D3 is important for absorption of calcium from the intestine, but also for depositing calcium into the bone in addition to vitamin K2. The WHI study mentioned above is highly significant because of a 1/3 reduction of hip fractures after 7 years of vitamin D3 and 1000 mg of calcium per day supplementation. If you add vitamin K2, exercise and bioidentical hormone replacement in postmenopausal women who need it, the prevention of hip fractures, wrist fractures and vertebral compression fractures likely will be as high as 50% in those who are taking their supplements regularly (compliance issues like forgetting the supplements or deliberately not taking them were mentioned in several of the studies).

Vitamin K2 helps to reduce heart attacks, strokes and osteoporosis

With the right supplementation, which includes vitamin K2 as mentioned above, you achieve that you lower your heart attack and stroke risk as the vitamin K2 removes the calcium from the blood vessels and deposits it into the bones, while at the same time strengthening your bones. Attention to proper nutrition, exercise and your hormone balance (using only bio-identical hormones to replace what’s missing) will also reinforce osteoporosis prevention. The bonus of using bioidentical hormone replacement therapy is that you prevent heart attacks and strokes in addition to preventing osteoporosis. I think that this is a good deal!

An easy-to-follow osteoporosis prevention program

The best combination is 1000 mg (or 1200 mg as per National Osteoporosis Foundation recommendation) of calcium per day together with 400 to 800 IU of vitamin D3 (for cancer prevention you may want to take 4000 IU to 5000 IU of vitamin D3 per day instead monitored by a 25-hydroxyvitamin D blood level test through your physician) and 100 to 200 micrograms of vitamin K2 (also called MK-7). In the age group above 50 several hormones can be missing.

Hormone depletion in menopause and andropause

That’s why the doctor recommends bioidentical testosterone in men and bioidentical progesterone/estrogen combinations in women with hormone depletion. This works best, if you also watch your weight and cut down your alcohol consumption to a minimum. Cutting alcohol out completely would be even better. In addition, exercise regularly as this builds up bone and muscle strength. It also helps, if you stick to a balanced diet (Mediterranean or Zone type diet). These diets are low-glycemic, low fat, wheat free and without sugar).

If you want to age gracefully, you need not only a healthy heart and a healthy brain. You also need healthy bones as this prevents disabilities.

References

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I received the following feedback (Originally on Nov. 10, 2013)

Dr. Ray, I read your March 17 Blog entry which suggested 100 ug of Vitamin K2 with 5000 IU of D3. I have atherosclerosis and have radically changed my diet (plant only), but also now take an average of about 3000 IU of Vitamin D3. Dr. Kate Rhéaume-Bleue (book on K2) recommended taking about 200 ug per day of K2, but increasing K2 to about 1,000 ug if taking around 5,000 IU of D3 to ensure proper activation of MGP. What is your opinion with regard to a D3/K2 ration? Thank you

Answer from Dr. Ray (Originally on Nov. 12, 2013, modified April 29, 2021)

I appreciate your question about what doses of vitamin K2 to take. There are varied recommendations, but I like to go by human trials and what they have actually shown. In this review in 2010 from the Life Extension Magazine a study is cited that showed that only 45 micrograms of vitamin K2 was enough to get the calcium out of the arterial walls and into the bones.

200 micrograms of Vitamin K2 daily

Dr. Mercola reviewed the literature and found that most investigators were now using 180 to 200 micrograms. In the past I took 100 micrograms of vitamin K2 per day. However, a few years ago I increased it to 200 micrograms per day. With regard to vitamin D3 absorption my anti-aging doctor found that I have an absorption problem regarding vitamin D3. This is why I need 10,000 IU of vitamin D3 daily. This brings my vitamin D blood level up into the high normal range (between 50 and 80 ng/mL). Toxic vitamin D blood levels start only above 150 ng/mL.

Avoid sugar and too much starch consumption

Remember that other risks for cardiovascular disease are sugar and starch consumption. The liver turns this into triglycerides and too much LDL cholesterol, which plugs up your arteries. Avoid wheat because of the gliadin content. This causes an addiction to wheat and sugary foods. Here is a summary how leaky gut syndrome and autoimmune illnesses may develop from this. If you want to consume beef, reduce your consumption to once or twice per week. It id best to stick to only eat grass fed, antibiotic free beef). But I rather prefer to eat organic chicken, turkey and lean pork. I understand that you have a plant only based diet, but I would recommend to you to reconsider that. Ask your doctor to check your ferritin from time to time. This way you do not miss an iron deficiency that may develop. For other readers: Don’t forget your vegetables (organic, please).

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Mar

2013

March Is Colorectal Cancer Awareness Month, So Let’s Discuss Prevention

By Ray Schilling | Cancer, Gastrointestinal Disease, Health, Men's Health, Prevention, Women’s Diseases

Introduction

March is colorectal cancer awareness month, so let’s discuss prevention. Only 40 years ago cancer of the cervix was one of the major killers for women, but with the introduction of the Pap test this has all changed. For those women who get that screening done, there is no need for fear. The mortality rate from cervical cancer since the 1970’s has steadily decreased as shown in this link.

As far as cancer of the prostate is concerned, a lot of progress with regard to early detection has been made due to the introduction of the PSA blood test, which is used as a method of screening. As a result men are diagnosed earlier with prostate cancer resulting in more cures as the cancer found is at an earlier stage. Here is a link depicting the effect of the PSA test on mortality rates from prostate cancer in time.

March is colorectal cancer awareness month, so let’s discuss prevention

March is colorectal cancer awareness month as this article explains. The key is early detection and treatment as with any type of cancer. Specifically, with rectal and colon cancer there are mostly no symptoms, as blood in stool or any other symptoms occur only late into the disease. What we do know, however, is that there is a long latent phase where precancerous mucous membrane changes lead to polyps and these will degenerate in time into cancer of the colon or rectum.

Not everyone has the same risk of developing colon cancer or rectal cancer. There are people with a higher rate of colorectal cancer, as they carry a susceptibility gene in their families. A healthy lifestyle can also reduce the risk of colorectal cancer.

March Is Colorectal Cancer Awareness Month, So Let’s Discuss Prevention

Polyps are the precancerous precursors for colorectal cancer

It is now widely accepted that polyps are the precancerous precursors for colorectal cancer and colonoscopies done on everybody starting at age 50 (those with family risk factors much earlier) have already been shown to have decreased the frequency of the disease as the data from the CDC show. The problem is that the survival curves for colorectal cancer have only a swallow incline. A steeper decline would mean better survival of colorectal cancer patients. In the case of the mortality rates of cervical cancer and prostate cancer the slope showed a more rapid decline translating int much better survival rates.

Not enough colonoscopies are done

The incidence of colon cancer should have gone down to almost the zero point. All that has been achieved so far is a reduction of a portion of cases (those who went for colonoscopies early enough before it turned into colon cancer); this is by far not an elimination of colorectal cancer. The reason for this is the fact that in many cases people have colonoscopies too late when the polyp has already turned cancerous, or invasive colon or rectal cancer is already present at the time of the first colonoscopy.

Designating March as colorectal awareness month makes a lot of sense to me

I happen to come from a family where my mother died in 1980 from colon cancer at the age of 59. Because of this my doctor told me that I have a risk of about 3-fold higher than the population at large to also develop colon cancer. I have had colonoscopies since the age of 40 every 3 years. Ironically a few days ago right during the colorectal awareness month, I was getting my 9^th colonoscopy. On three occasions polyps were removed, which tells me that the cancer-screening program works!

Why screen for colon cancer in regular intervals?

So why is it important to screen in regular intervals? One reason is that we are now exposed to more toxic chemicals in our environment and food than 100 years ago. So all cancers, but especially colorectal cancer rates have increased. We know the pathophysiology, which is the science that studies how an illness develops. We know that it takes several years between the occurrence of the first precancerous cells that form in the lining of the gut (called “mucosa”) and the formation of polyps. It takes another few years before polyps turn cancerous. This means that there is enough of a time interval to do screening. If we are not aware of this and ignore it (as unfortunately many people do), the process will run down the conveyor belt on an automatic program, which ends up in end stage colorectal cancer. The stages of colon cancer are depicted in this link.

Invasive colon cancer is deadly

As the table of my chapter on colon cancer staging shows, the invasive end stage colon cancer (stage IV or Duke D) has a 5-year survival rate of only 6%. Even when the cancer is limited to stage II (also called Duke stage B) there would be a 5-year survival of only 80% (see table in link).

What does screening really achieve? On an individual basis the gastroenterologist who does the colonoscopy can screen the whole colon for premalignant polyps and remove them during the procedure. This moves the potential cancer staging backwards to beyond any detectable cancer, as all of the potential early cancer cells would have been inside the polyp (called local “in situ” disease) and were removed by cauterizing the stalk (see above link). There is another potential factor that can help to reduce colorectal cancer incidence: Recently a connection was made between

Helicobacter pylori as a risk factor for colorectal cancer

Helicobacter pylori (H. pylori) infection of the stomach and polyps in the colon as well as colon cancer. In the past several smaller studies failed to show this correlation. It took 156,269 patients in this study to show that there was a correlation. As H. pylori is being tested for and treated more and more, this will also have a positive effect on lowering the frequency of colorectal cancer.

Mass colonoscopy screening

On a population basis with mass colonoscopy screening the incidence of colorectal cancer is reduced. The reduction of colon cancer would be much faster. Eventually it would turn into a disease similar to cancer of the cervix. Here it still matters whether you screen or not, but very few people have to suffer from it. Here is an image from a paper (look for Fig. 2, halfway down the page). It shows that survival benefits (longer lives) are registered only after 10 years or more following colonoscopy.

Colorectal cancer statistics

Every polyp that is removed will add up to the colon and rectum health of the nation at large. This shows statistically, when you sum up all of the colonoscopies done around the country year after year. We need a nationwide and worldwide awareness that colorectal cancer screening is something worthwhile doing. This cancer is the third most frequent cancer in many parts of the world.

I am grateful that colonoscopy screening works, as I had polyps removed three times over a 29 year span and I did not have to go through all the surgical procedures that my mother had to endure. Had I lived 50 years earlier I may not have lived long enough to tell you how important colonoscopy screening is.

Here are the recommendations

1. 1. Let us assume there is no risk of colorectal cancer in your family. In this case screen once at the age of 50. This makes sure you are not one of the spontaneous colorectal polyp producers. If OK, screen every 10 years provided the colonoscopy is always negative.
  2. A family history of direct bloodline relative increases the risk for colorectal cancer. Direct bloodline relatives are: mother, father, brother or sister. If one of them had cancer of the colon or rectum, you have a higher cancer risk. In these individuals a gastroenterologist must do colonoscopies every 3 years.

Missed polyps during a colonoscopy

1. 1. There may be up to 15% of missed polyps during a colonoscopy. But with the next colonoscopy there is a high likelihood that the physician catches the abnormal polyp in time. The pathologist confirms that the subsequent screening caught them before they turn cancerous.
  2. There are special cases, families with genetic syndromes like the familial polyposis of the colon. In these families a gastroenterologist needs to screen children/young adults for polyps when they are still young. This is from the age of 20 to 25 years onwards.

Don’t complain, if you belong to category 1 or 2 as it could be much worse (category 3). Cancer is serious business. Remember, March is colorectal cancer awareness month.

More information about colon cancer.