Aug
01
2008

Osteoporosis Drug Prevents Breast Cancer Recurrence

By | Cancer, Osteoporosis

Standards in breast cancer treatment have been surgery, radiation therapy and chemotherapy. In hormone receptor positive cancer types Tamoxifen has been the drug of choice for many years to achieve suppression of the ovaries in premenopausal women. A new medication under the name of Anastrozole has also been introduced. In the meantime researchers have examined the success of the various approaches. No difference has been found between Anastrozole and Tamoxifen, but a new drug which has been used for osteoporosis patients shows that it can boost disease free survival for breast cancer patients. The medication called zoledronic acid taken in combination with either Tamoxifen or Anastrozole can increase disease free breast cancer survival by 36%. Zoledronic acid can inhibit tumor cell growth and stimulate the immune response, and the lead author of the study, Dr. Michael Gnant concludes that the combination treatment creates a tumor-hostile environment. The benefits are not only a reduction of bone metastases but others as well.

Osteoporosis Drug Prevents Breast Cancer Recurrence

The most concerning side effect is osteonecrosis of the jaw, but the researcher reported that in the trial not a single case has materialized. Other researchers, such as Dr. Martine Piccart-Gebhart , professor at the department of oncology at the University of Brussels caution that this is an important trial, but it should not be seen as a practice-changing trial. More work is needed to establish the best dosage and treatment schedule. More results from other trials investigating the combination treatment with zoledronic acid are expected this summer.

More information about breast cancer: http://nethealthbook.com/cancer-overview/breast-cancer/

National Review of Medicine, June 2008, page 18 and 19

Comment on Nov. 17, 2012: There is criticism regarding Zoledronic Acid because of osteonecrosis of the jaw and the fact that biophosphonates also have the metatasis suppressing effect. See this link.

Last edited November 4, 2014

Feb
01
2007

Lycopene Benefits Backed By Science

By | Cancer, Diabetes, Health, Heart Disease, Nutrition, Osteoporosis

Lately a lot of attention has been directed to the health benefits of vegetables and fruit. Vitamin C has long been an accepted household term, and nobody questions the benefits. Newer buzz words are the terms “bioflavonoids” and “antioxidants”. Some products are aggressively marketed extolling the above named beneficial substances, but often the consumer is left mildly bewildered by exaggerated claims. Often the sale prices of these miracle foods are as lofty as the bold statements that go along with them.
For any shopper it is important to know that some of the most beneficial foods are not high priced items, but very common staples. Take tomatoes, for instance. They are a significant source for the substance lycopene, which lately has received a lot of attention. Lycopene and its dietary sources as well as its benefits have been researched world wide, and the results are now in. It is responsible for the red color in fruit or vegetables, such as tomatoes, and its isomeric form 5-cis-lycopene is the most stable form having the highest antioxidant properties. Common dietary sources are tomatoes, watermelons, pink guava, pink grapefruit, papaya, apricot and other fruit. In the Western diet tomato-based foods account for about 85% of dietary sources of Lycopene. Studies have shown that lycopene is more efficiently absorbed from processed tomato products compared to raw tomatoes. Once it is absorbed it is distributed throughout the body. The highest levels showed up in the testes, the adrenal glands, prostate, breast and liver.
Research going back to 1995 showed an inverse relationship between the consumption of tomatoes and the risk of prostate cancer. A follow up publication in 1999 showed that the same inverse relation of lycopene intake and cancer also included breast, cervical, ovarian, liver and other organ sites. Further studies have followed these initial publications, and the great majority of them suggest that an increased intake of lycopene showed an association with a significant reduction in the risk of many cancers.
Coronary heart disease and lycopene benefits were also examined. The strongest population based evidence comes from a multi center case control study in Europe (EURAMIC). 662 Cases and 717 controls were recruited from 10 different European countries, and there was a significant relationship between levels of lycopene in fatty tissue and the risk of myocardial infarction. Lower lycopene levels were associated with a higher risk of heart attacks.Lycopene was also shown to decrease levels of oxidized LDL (LDL or low density lipoprotein is known as the “bad” cholesterol). Another small study showed that lycopene was reducing total cholesterol levels and as a result was lowering the risk of coronary heart disease (CHD).
The list of benefits does not end here: the dietary oxidant reduces oxidative stress and levels of bone turnover markers, meaning that it may contribute to the bone health, especially reducing the risk of osteoporosis in postmenopausal women.

Lycopene Benefits Backed By Science

Lycopene Benefits Backed By Science

For people with mild hypertension (high blood pressure), consumption of lycopene resulted in significant reductions of systolic and diastolic blood pressures.
Infertility in males was significantly helped by lycopene intake. In a study infertile man received 8 mg lycopene per day in capsule form. Laboratory tests confirmed an increased sperm density along with functional sperm concentration and mobility. This treatment protocol with lycopene supplementation resulted in a success rate of 36% pregnancies in their partners.
Pregnant women with pre-eclampsia who were treated with lycopene supplement significantly improved, which was shown by decreased diastolic blood pressure, the reduction of pre-eclampsia and a decrease of intrauterine growth retardation, resulting in a healthier mother and baby.
Future research is pending surrounding lycopene in metabolic and inflammatory diseases and in its role of possibly preventing neurodegenerative diseases such as Alzheimer’s disease. Other inflammatory conditions such as arthritis and emphysema will likely also be shown to benefit from lycopene. Preliminary data has already indicated this.
The Food and Drug Administration (FDA) of USA has recently approved lycopene as a safe “natural coloring agent” and a Generally Recognized as a Safe (GRAS) component. The Department of Nutritional Sciences , Faculty of Medicine, University of Toronto, c/o Dr. A.V. Rao et al. who completed this meta analysis of the recent literature have recommended that we all consume a regular daily lycopene dose in our food and supplements as part of our diet for good health.

More info about lycopene and prostate cancer: http://nethealthbook.com/news/lycopene-reduces-prostate-cancer-risk/

Reference: The Whitehall-Robins Report, December 2006, Volume 15, No.4

Last edited November 2, 2014

Dec
01
2005

Lycopene For Bone Health

By | Nutrition, Osteoporosis, Prevention, Women’s Diseases

The tomato pigment Lycopene in the diet has been demonstrated to be a beneficial agent in reducing age-related diseases, cardio-vascular disease and even prostate cancer. A new aspect has now been investigated.
Consuming more lycopene in the diet is of significant benefit to post-menopausal women, as it reduces oxidative stress and bone turnover. The findings come from head researcher Erin Collins from the University of Toronto. The study results also suggest, that dietary lycopene is readily absorbed, particularly in combination with vitamin C. These results are encouraging, as lycopene may be one of the main agents important for the prevention of osteoporosis.” We found that women who consumed more tomato products on a daily basis had a lower bone turnover and lower oxidative stress than women of the same age group who did not consume as much”, reports Ms. Collins. The participants of the research project were between 50 and 60 years. Lycopene levels in the blood were analyzed, and a seven-day food record was completed. The lowest quartile of estimated lycopene intake was 1.8 mg per day, and the highest was 8 mg per day. Lab tests also showed that higher levels of lycopene were associated with a lower level of protein oxidation and cross-linked N-telopeptides of type I collagen, for short NTx. The latter one is a marker of bone turnover. The intake of vitamin C appeared to work together with lycopene, but it only showed to have a correlation, if 500 mg per day or more of vitamin C was consumed. The effect was not observed among the volunteers who consumed less than 500 mg per day of vitamin C.
An intervention study will begin shortly, which will be the first of its kind. It will assess the bone parameters in women treated with different doses of lycopene pills.

Lycopene For Bone Health

Lycopene For Bone Health

It is likely that follow-up studies will confirm initial findings, and dietary lycopene could become a simple, inexpensive way of helping to prevent osteoporosis.

More information about osteoporosis: http://nethealthbook.com/arthritis/osteoporosis/

Reference: The Medical Post, October 11, 2005, page 8

Last edited October 29, 2014